Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP⁺-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

by Ichiro Kawahata, Luc Bousset, Ronald Melki, Kohji Fukunaga
Published 2019-10-01

Structure and assembly properties of the N-terminal domain of the prion Ure2p in isolation and in its natural context.

by Luc Bousset, Jonathan Bonnefoy, Yannick Sourigues, Frank Wien, Ronald Melki
Published 2010-01-01

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

by Jeshlee Vijayakumar, Charlène Perrois, Marjorie Heim, Luc Bousset, Simon Alberti, Florence Besse
Published 2019-06-01

Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice

by Kazuya Matsuo, Yasushi Yabuki, Ronald Melki, Luc Bousset, Yuji Owada, Kohji Fukunaga
Published 2021-01-01

Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity.

by Julia Gath, Luc Bousset, Birgit Habenstein, Ronald Melki, Anja Böckmann, Beat H Meier
Published 2014-01-01

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

by Javier María Peralta Ramos, Pablo Iribarren, Luc Bousset, Ronald Melki, Veerle Baekelandt, Anke Van der Perren
Published 2019-01-01

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

by Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Published 2019-09-01

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

by Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Published 2019-02-01

Prion Amyloid Polymorphs – The Tag Might Change It All

by Luc Bousset, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schütz, Ronald Melki, Beat H. Meier, Anja Böckmann
Published 2020-08-01

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged f...

by Alexis Fenyi, Charles Duyckaerts, Luc Bousset, Heiko Braak, Kelly Del Tredici, Ronald Melki, on behalf of the Brainbank Neuro-CEB Neuropathology Network
Published 2021-01-01

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

by Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga
Published 2021-01-01

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

by Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Published 2019-12-01

Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation

by Marina Célestine, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, Marc Dhenain
Published 2023-04-01

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

by Benedict Tanudjojo, Samiha S. Shaikh, Alexis Fenyi, Luc Bousset, Devika Agarwal, Jade Marsh, Christos Zois, Sabrina Heman-Ackah, Roman Fischer, David Sims, Ronald Melki, George K. Tofaris
Published 2021-06-01

Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectromet...

by Amulya Nidhi Shrivastava, Virginie Redeker, Nicolas Fritz, Laura Pieri, Leandro G. Almeida, Maria Spolidoro, Thomas Liebmann, Luc Bousset, Marianne Renner, Clément Léna, Anita Aperia, Ronald Melki, Antoine Triller
Published 2016-06-01

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

by Jian-Jun Guo, Feng Yue, Dong-Yan Song, Luc Bousset, Xin Liang, Jing Tang, Lin Yuan, Wen Li, Ronald Melki, Yong Tang, Piu Chan, Chuang Guo, Jia-Yi Li
Published 2021-01-01

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

by Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Lucie Delattre, Sébastien Carrier, Anne Loyens, Marie-Christine Galas, Luc Bousset, Ronald Melki, Gwennaëlle Aurégan, Philippe Hantraye, Emmanuel Brouillet, Luc Buée, Morvane Colin
Published 2014-01-01

Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates

by Audrey Fayard, Alexis Fenyi, Sonia Lavisse, Sandra Dovero, Luc Bousset, Tracy Bellande, Sophie Lecourtois, Christophe Jouy, Martine Guillermier, Caroline Jan, Pauline Gipchtein, Benjamin Dehay, Erwan Bezard, Ronald Melki, Philippe Hantraye, Romina Aron Badin
Published 2023-05-01

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

by Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Published 2021-03-01

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions

by Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Published 2022-03-01