Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes

by Lotta Luca A, Wang Mark, Yu Jin, Martinelli Ida, Yu Fuli, Passamonti Serena M, Consonni Dario, Pappalardo Emanuela, Menegatti Marzia, Scherer Steven E, Lewis Lora L, Akbar Humeira, Wu Yuanqing, Bainbridge Matthew N, Muzny Donna M, Mannucci Pier M, Gibbs Richard A, Peyvandi Flora
Published 2012-02-01

Risk-taking summary statistics UK Biobank

by Clifton, EAD, Perry, John RB, Imamura, Fumiaki, Lotta, Luca A, Brage, Soren, Forouhi, Nita G, Griffin, Simon, Wareham, Nick, Ong, Ken K, Day, Felix
Published 2018

Research data supporting: Genome–wide association study for risk taking propensity indicates shared pathways with body mass index

by Clifton, Emma AD, Perry, John RB, Imamura, Fumiaki, Lotta, Luca A, Brage, Soren, Forouhi, Nita G, Griffin, Simon, Wareham, Nick, Ong, Ken K, Day, Felix R
Published 2018

Genomic insights into the causes of type 2 diabetes.

by Langenberg, Claudia, Lotta, Luca A
Published 2018

A cross-platform approach identifies genetic regulators of human metabolism and health.

by Lotta, Luca A, Pietzner, Maik, Stewart, Isobel D, Wittemans, Laura BL, Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K, Oliver-Williams, Clare, Auyeung, Victoria PW, Luan, Jian'an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A, Scott, Robert A, Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G, Khaw, Kay-Tee, MacTel Consortium, Griffin, Julian L, Wood, Angela M, Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S, Gribble, Fiona M, Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J, Langenberg, Claudia
Published 2021

Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches.

by Wittemans, Laura BL, Lotta, Luca A, Langenberg, Claudia
Published 2018

Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.

by Clifton, Emma AD, Perry, John RB, Imamura, Fumiaki, Lotta, Luca A, Brage, Soren, Forouhi, Nita G, Griffin, Simon J, Wareham, Nicholas J, Ong, Ken K, Day, Felix R
Published 2018

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.

by Mardinoglu, Adil, Gogg, Silvia, Lotta, Luca A, Stančáková, Alena, Nerstedt, Annika, Boren, Jan, Blüher, Matthias, Ferrannini, Ele, Langenberg, Claudia, Wareham, Nicholas J, Laakso, Markku, Smith, Ulf
Published 2018

Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.

by Kulyté, Agné, Lundbäck, Veroniqa, Lindgren, Cecilia M, Luan, Jian'an, Lotta, Luca A, Langenberg, Claudia, Arner, Peter, Strawbridge, Rona J, Dahlman, Ingrid
Published 2020

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

by Lotta, Luca A, Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J, Luan, Jian'an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D, Wheeler, Eleanor, Day, Felix R, Perry, John RB, Langenberg, Claudia, Wareham, Nicholas J, Farooqi, I Sadaf
Published 2019

Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.

by Kulyté, Agné, Lundbäck, Veroniqa, Lindgren, Cecilia M, Luan, Jian'an, Lotta, Luca A, Langenberg, Claudia, Arner, Peter, Strawbridge, Rona J, Dahlman, Ingrid
Published 2020

Assessing the causal association of glycine with risk of cardio-metabolic diseases.

by Wittemans, Laura BL, Lotta, Luca A, Oliver-Williams, Clare, Stewart, Isobel D, Surendran, Praveen, Karthikeyan, Savita, Day, Felix R, Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L, Forouhi, Nita G, Scott, Robert A, Wood, Angela M, Burgess, Stephen, Howson, Joanna MM, Danesh, John, Wareham, Nicholas J, Butterworth, Adam S, Langenberg, Claudia
Published 2019

Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis.

by Yarmolinsky, James, Bonilla, Carolina, Haycock, Philip C, Langdon, Ryan JQ, Lotta, Luca A, Langenberg, Claudia, Relton, Caroline L, Lewis, Sarah J, Evans, David M, PRACTICAL Consortium, Davey Smith, George, Martin, Richard M
Published 2018

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study.

by Cardona, Alexia, Day, Felix R, Perry, John RB, Loh, Marie, Chu, Audrey Y, Lehne, Benjamin, Paul, Dirk S, Lotta, Luca A, Stewart, Isobel D, Kerrison, Nicola D, Scott, Robert A, Khaw, Kay-Tee, Forouhi, Nita G, Langenberg, Claudia, Liu, Chunyu, Mendelson, Michael M, Levy, Daniel, Beck, Stephan, Leslie, R David, Dupuis, Josée, Meigs, James B, Kooner, Jaspal S, Pihlajamäki, Jussi, Vaag, Allan, Perfilyev, Alexander, Ling, Charlotte, Hivert, Marie-France, Chambers, John C, Wareham, Nicholas J, Ong, Ken K
Published 2019

Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.

by Bowker, Nicholas, Shah, Rupal L, Sharp, Stephen J, Luan, Jian'an, Stewart, Isobel D, Wheeler, Eleanor, Ferreira, Manuel AR, Baras, Aris, Wareham, Nicholas J, Langenberg, Claudia, Lotta, Luca A
Published 2020

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

by Lotta, Luca A, Gulati, Pawan, Day, Felix R, Payne, Felicity, Ongen, Halit, van de Bunt, Martijn, Gaulton, Kyle J, Eicher, John D, Sharp, Stephen J, Luan, Jian'an, De Lucia Rolfe, Emanuella, Stewart, Isobel D, Wheeler, Eleanor, Willems, Sara M, Adams, Claire, Yaghootkar, Hanieh, EPIC-InterAct Consortium, Cambridge FPLD1 Consortium, Forouhi, Nita G, Khaw, Kay-Tee, Johnson, Andrew D, Semple, Robert K, Frayling, Timothy, Perry, John RB, Dermitzakis, Emmanouil, McCarthy, Mark I, Barroso, Inês, Wareham, Nicholas J, Savage, David B, Langenberg, Claudia, O'Rahilly, Stephen, Scott, Robert A
Published 2016

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.

by Chen, Zhifen, Yu, Haojie, Shi, Xu, Warren, Curtis R, Lotta, Luca A, Friesen, Max, Meissner, Torsten B, Langenberg, Claudia, Wabitsch, Martin, Wareham, Nick, Benson, Mark D, Gerszten, Rob E, Cowan, Chad A
Published 2019

Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis.

by Lotta, Luca A, Abbasi, Ali, Sharp, Stephen J, Sahlqvist, Anna-Stina, Waterworth, Dawn, Brosnan, Julia M, Scott, Robert A, Langenberg, Claudia, Wareham, Nicholas J
Published 2015

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.

by Yaghootkar, Hanieh, Lotta, Luca A, Tyrrell, Jessica, Smit, Roelof AJ, Jones, Sam E, Donnelly, Louise, Beaumont, Robin, Campbell, Archie, Tuke, Marcus A, Hayward, Caroline, Ruth, Katherine S, Padmanabhan, Sandosh, Jukema, J Wouter, Palmer, Colin C, Hattersley, Andrew, Freathy, Rachel M, Langenberg, Claudia, Wareham, Nicholas J, Wood, Andrew R, Murray, Anna, Weedon, Michael N, Sattar, Naveed, Pearson, Ewan, Scott, Robert A, Frayling, Timothy M
Published 2016

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

by Yu, Bing, Zanetti, Krista A, Temprosa, Marinella, Albanes, Demetrius, Appel, Nathan, Barrera, Clara Barrios, Ben-Shlomo, Yoav, Boerwinkle, Eric, Casas, Juan P, Clish, Clary, Dale, Caroline, Dehghan, Abbas, Derkach, Andriy, Eliassen, A Heather, Elliott, Paul, Fahy, Eoin, Gieger, Christian, Gunter, Marc J, Harada, Sei, Harris, Tamara, Herr, Deron R, Herrington, David, Hirschhorn, Joel N, Hoover, Elise, Hsing, Ann W, Johansson, Mattias, Kelly, Rachel S, Khoo, Chin Meng, Kivimäki, Mika, Kristal, Bruce S, Langenberg, Claudia, Lasky-Su, Jessica, Lawlor, Deborah A, Lotta, Luca A, Mangino, Massimo, Le Marchand, Loïc, Mathé, Ewy, Matthews, Charles E, Menni, Cristina, Mucci, Lorelei A, Murphy, Rachel, Oresic, Matej, Orwoll, Eric, Ose, Jennifer, Pereira, Alexandre C, Playdon, Mary C, Poston, Lucilla, Price, Jackie, Qi, Qibin, Rexrode, Kathryn, Risch, Adam, Sampson, Joshua, Seow, Wei Jie, Sesso, Howard D, Shah, Svati H, Shu, Xiao-Ou, Smith, Gordon CS, Sovio, Ulla, Stevens, Victoria L, Stolzenberg-Solomon, Rachael, Takebayashi, Toru, Tillin, Therese, Travis, Ruth, Tzoulaki, Ioanna, Ulrich, Cornelia M, Vasan, Ramachandran S, Verma, Mukesh, Wang, Ying, Wareham, Nick J, Wong, Andrew, Younes, Naji, Zhao, Hua, Zheng, Wei, Moore, Steven C
Published 2019