Fast and flexible linear mixed models for genome-wide genetics.

by Daniel E Runcie, Lorin Crawford
Published 2019-02-01

Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits.

by Wei Cheng, Sohini Ramachandran, Lorin Crawford
Published 2020-06-01

Uncertainty quantification in variable selection for genetic fine-mapping using bayesian neural networks

by Wei Cheng, Sohini Ramachandran, Lorin Crawford
Published 2022-07-01

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.

by Lorin Crawford, Ping Zeng, Sayan Mukherjee, Xiang Zhou
Published 2017-07-01

MegaLMM: Mega-scale linear mixed models for genomic predictions with thousands of traits

by Daniel E. Runcie, Jiayi Qu, Hao Cheng, Lorin Crawford
Published 2021-07-01

Multi-scale inference of genetic trait architecture using biologically annotated neural networks.

by Pinar Demetci, Wei Cheng, Gregory Darnell, Xiang Zhou, Sohini Ramachandran, Lorin Crawford
Published 2021-08-01

Deep self-supervised learning for biosynthetic gene cluster detection and product classification.

by Carolina Rios-Martinez, Nicholas Bhattacharya, Ava P Amini, Lorin Crawford, Kevin K Yang
Published 2023-05-01

Discovering non-additive heritability using additive GWAS summary statistics

by Samuel Pattillo Smith, Gregory Darnell, Dana Udwin, Julian Stamp, Arbel Harpak, Sohini Ramachandran, Lorin Crawford
Published 2024-06-01

Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila.

by Adam N Spierer, Jim A Mossman, Samuel Pattillo Smith, Lorin Crawford, Sohini Ramachandran, David M Rand
Published 2021-03-01

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

by Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir, Kris C. Wood
Published 2018-08-01

A topological data analytic approach for discovering biophysical signatures in protein dynamics.

by Wai Shing Tang, Gabriel Monteiro da Silva, Henry Kirveslahti, Erin Skeens, Bibo Feng, Timothy Sudijono, Kevin K Yang, Sayan Mukherjee, Brenda Rubenstein, Lorin Crawford
Published 2022-05-01

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

by Grace R. Anderson, Peter S. Winter, Kevin H. Lin, Daniel P. Nussbaum, Merve Cakir, Elizabeth M. Stein, Ryan S. Soderquist, Lorin Crawford, Jim C. Leeds, Rachel Newcomb, Priya Stepp, Catherine Yip, Suzanne E. Wardell, Jennifer P. Tingley, Moiez Ali, Mengmeng Xu, Meagan Ryan, Shannon J. McCall, Autumn J. McRee, Christopher M. Counter, Channing J. Der, Kris C. Wood
Published 2017-07-01

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

by Katherine R. Singleton, Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophelia Maertens, Xiaojing Liu, Maria V. Liberti, Anniefer N. Magpusao, Elizabeth M. Stein, Jennifer P. Tingley, Dennie T. Frederick, Genevieve M. Boland, Keith T. Flaherty, Shannon J. McCall, Clemens Krepler, Katrin Sproesser, Meenhard Herlyn, Drew J. Adams, Jason W. Locasale, Karen Cichowski, Sayan Mukherjee, Kris C. Wood
Published 2017-12-01