T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes

by Stephanie Mueller, Jérémy Huard, Katharina Waldow, Xiaoyun Huang, Lorenza A D'Alessandro, Sebastian Bohl, Kathleen Börner, Dirk Grimm, Steffen Klamt, Ursula Klingmüller, Marcel Schilling
Published 2015-03-01

Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue

by Daniel Budelmann, Hendrik Laue, Nick Weiss, Uta Dahmen, Lorenza A. D’Alessandro, Ina Biermayer, Ursula Klingmüller, Ahmed Ghallab, Reham Hassan, Brigitte Begher-Tibbe, Jan G. Hengstler, Lars Ole Schwen
Published 2022-01-01

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

by Lorenza A D'Alessandro, Regina Samaga, Tim Maiwald, Seong-Hwan Rho, Sandra Bonefas, Andreas Raue, Nao Iwamoto, Alexandra Kienast, Katharina Waldow, Rene Meyer, Marcel Schilling, Jens Timmer, Steffen Klamt, Ursula Klingmüller
Published 2015-04-01

Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease

by Sebastian Burbano de Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Published 2024-01-01

Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation

by Seddik Hammad, Christoph Ogris, Amnah Othman, Pia Erdoesi, Wolfgang Schmidt-Heck, Ina Biermayer, Barbara Helm, Yan Gao, Weronika Piorońska, Christian H. Holland, Lorenza A. D’Alessandro, Carolina de la Torre, Carsten Sticht, Sherin Al Aoua, Fabian J. Theis, Heike Bantel, Matthias P. Ebert, Ursula Klingmüller, Jan G. Hengstler, Steven Dooley, Nikola S. Mueller
Published 2023-07-01

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

by Rene eMeyer, Lorenza A D`Alessandro, Sandip eKar, Sandip eKar, Bernhard eKramer, Bin eShe, Daniel eKaschek, Bettina eHahn, David eWrangborg, Johan eKarlsson, Mats eKvarnstrom, Mats eJirstrand, Wolf-Dieter eLehmann, Jens eTimmer, Jens eTimmer, Jens eTimmer, Jens eTimmer, Jens eTimmer, Thomas eHöfer, Thomas eHöfer, Ursula eKlingmüller, Ursula eKlingmüller
Published 2012-11-01

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

by Svantje Sobotta, Andreas Raue, Xiaoyun Huang, Joep Vanlier, Joep Vanlier, Anja Jünger, Sebastian Bohl, Ute Albrecht, Maximilian J. Hahnel, Stephanie Wolf, Nikola S. Mueller, Lorenza A. D'Alessandro, Stephanie Mueller-Bohl, Martin E. Boehm, Philippe Lucarelli, Sandra Bonefas, Georg Damm, Daniel Seehofer, Wolf D. Lehmann, Stefan Rose-John, Frank van der Hoeven, Norbert Gretz, Fabian J. Theis, Fabian J. Theis, Christian Ehlting, Johannes G. Bode, Jens Timmer, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Published 2017-10-01