Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.

by Diana Gabriel, Leslie B Gordon, Karima Djabali
Published 2016-01-01

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B

by Kamsi O. Odinammadu, Khurts Shilagardi, Kelsey Tuminelli, Daniel P. Judge, Leslie B. Gordon, Susan Michaelis
Published 2023-12-01

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.

by Dayle McClintock, Desiree Ratner, Meepa Lokuge, David M Owens, Leslie B Gordon, Francis S Collins, Karima Djabali
Published 2007-12-01

Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

by Vera Wenzel, Daniela Roedl, Diana Gabriel, Leslie B. Gordon, Meenhard Herlyn, Reinhard Schneider, Johannes Ring, Karima Djabali
Published 2012-04-01

Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome

by Leslie B. Gordon, Leslie B. Gordon, Leslie B. Gordon, Sammy Basso, Sammy Basso, Sammy Basso, Sammy Basso, Justine Maestranzi, Elena Aikawa, Cassandra L. Clift, Antonio Giovanni Cammardella, Tommaso Hinna Danesi, Pedro J. del Nido, Elazer R. Edelman, Elazer R. Edelman, Abeer Hamdy, Sheila M. Hegde, Monica E. Kleinman, Nicola Maschietto, Mandeep R. Mehra, Srinivasan Mukundan, Srinivasan Mukundan, Francesco Musumeci, Marco Russo, Frank J. Rybicki, Pinak Bipin Shah, William A. Suarez, Kelsey Tuminelli, Katherine Zaleski, Ashwin Prakash, Marie Gerhard-Herman
Published 2024-04-01

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.

by Jackleen Marji, Seán I O'Donoghue, Dayle McClintock, Venkata P Satagopam, Reinhard Schneider, Desiree Ratner, Howard J Worman, Leslie B Gordon, Karima Djabali
Published 2010-06-01

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome

by Sae-Il Murtada, Nicole Mikush, Mo Wang, Pengwei Ren, Yuki Kawamura, Abhay B Ramachandra, David S Li, Demetrios T Braddock, George Tellides, Leslie B Gordon, Jay D Humphrey
Published 2023-03-01

Abnormal Myocardial Deformation Despite Normal Ejection Fraction in Hutchinson‐Gilford Progeria Syndrome

by Flemming J. Olsen, Tor Biering‐Sørensen, Fatima Lunze, Sheila M. Hegde, Steven D. Colan, Rachel Ehrbar, Joseph Massaro, Alessandra M. Ferraro, David M. Harrild, Monica E. Kleinman, Leslie B. Gordon, Ashwin Prakash
Published 2024-02-01

Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts

by Gabriel, Diana, Roedl, Daniela, Gordon, Leslie B, Djabali, Karima
Published 2015

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

by Gabriel, Diana, Shafry, Dinah Dorith, Gordon, Leslie B., Djabali, Karima
Published 2017

Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts

by DuBose, Amanda J., Lichtenstein, Stephen T., Petrash, Noreen M., Erdos, Michael R., Gordon, Leslie B., Collins, Francis S.
Published 2018

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype

by Gabriel, Diana, Gordon, Leslie B., Djabali, Karima
Published 2017