Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

by Leroy Versteeg, Mashal M. Almutairi, Peter J. Hotez, Jeroen Pollet
Published 2019-09-01

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by Neima Briggs, Leroy Versteeg, Bin Zhan, Rojelio Mejia, Brian Keegan, Coreen Beaumier, Jagannadha Sastry, Maria Elena Bottazzi, Peter Hotez
Published 2017-09-01

A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection.

by Meagan A Barry, Leroy Versteeg, Qian Wang, Jeroen Pollet, Bin Zhan, Fabian Gusovsky, Maria Elena Bottazzi, Peter J Hotez, Kathryn M Jones
Published 2019-05-01

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi.

by Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet
Published 2021-09-01

Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection.

by Leroy Versteeg, Junfei Wei, Zhuyun Liu, Brian Keegan, Ricardo T Fujiwara, Kathryn M Jones, Oluwatoyin Asojo, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
Published 2020-02-01

The zebrafish as a potential model for vaccine and adjuvant development

by Peter J. Hotez, Maria Elena Bottazzi, Nelufa Yesmin Islam, Jungsoon Lee, Jeroen Pollet, Cristina Poveda, Ulrich Strych, Syamala Rani Thimmiraju, Nestor L. Uzcategui, Leroy Versteeg, Daniel Gorelick
Published 2024-12-01

Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease

by Kathryn M. Jones, Kathryn M. Jones, Elise N. Mangin, Corey L. Reynolds, Liliana E. Villanueva, Liliana E. Villanueva, Julio Vladimir Cruz, Julio Vladimir Cruz, Leroy Versteeg, Leroy Versteeg, Brian Keegan, April Kendricks, Jeroen Pollet, Fabian Gusovsky, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez
Published 2023-02-01

Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

by Junfei Wei, Leroy Versteeg, Zhuyun Liu, Brian Keegan, Ana Clara Gazzinelli-Guimarães, Ricardo T Fujiwara, Neima Briggs, Kathryn M Jones, Ulrich Strych, Coreen M Beaumier, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
Published 2017-07-01

Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection

by Julio V. Cruz-Chan, Liliana E. Villanueva-Lizama, Leroy Versteeg, Ashish Damania, Maria José Villar, Cristina González-López, Brian Keegan, Jeroen Pollet, Fabian Gusovsky, Peter J. Hotez, Maria Elena Bottazzi, Kathryn M. Jones
Published 2021-02-01

Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm.

by Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S Hayes, Coreen Beaumier, Christopher A Seid, Jamie Leong, Richard K Grencis, Maria Elena Bottazzi, K Jagannadha Sastry, Peter J Hotez
Published 2018-08-01

Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-ce...

by Cristina Poveda, Ana Carolina Leão, Chiara Mancino, Francesca Taraballi, Yi-Lin Chen, Rakesh Adhikari, Maria Jose Villar, Rakhi Kundu, Duc M. Nguyen, Leroy Versteeg, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi, Jeroen Pollet, Kathryn M. Jones
Published 2023-01-01

Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine

by William R. Lykins, Jeroen Pollet, Jeroen Pollet, Jessica A. White, Brian Keegan, Brian Keegan, Leroy Versteeg, Leroy Versteeg, Ulrich Strych, Ulrich Strych, Wen-Hsiang Chen, Wen-Hsiang Chen, Raodoh Mohamath, Gabi Ramer-Denisoff, Sierra Reed, Samuel Beaver, Alana Gerhardt, Emily A. Voigt, Mark A. Tomai, Robert Sitrin, Robert K. M. Choy, Frederick J. Cassels, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Christopher B. Fox, Christopher B. Fox
Published 2024-02-01

Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease

by Christopher A. Seid, Kathryn M. Jones, Jeroen Pollet, Brian Keegan, Elissa Hudspeth, Molly Hammond, Junfei Wei, C. Patrick McAtee, Leroy Versteeg, Amanda Gutierrez, Zhuyun Liu, Bin Zhan, Jonathan L. Respress, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez
Published 2017-03-01

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice

by Jeroen Pollet, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rahki Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Ana Carolina de Araujo Leao, Joanne Altieri Rivera, Zoha Momin, Portia M. Gillespie, Jason T. Kimata, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi
Published 2021-08-01

A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2

by Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Rakhi Kundu, Yi-Lin Chen, Suman Sharma, Karm Ghei, Brian Keegan, Leroy Versteeg, Portia M. Gillespie, Allan Ciciriello, Nelufa Y. Islam, Cristina Poveda, Nestor Uzcategui, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Published 2023-10-01

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

by Peter J. Hotez, Rakesh Adhikari, Wen-Hsiang Chen, Yi-Lin Chen, Portia Gillespie, Nelufa Y. Islam, Brian Keegan, Rakhi Tyagi Kundu, Jungsoon Lee, Zhuyun Liu, Jason T. Kimata, Numan Oezguen, Jeroen Pollet, Cristina Poveda, Kay Razavi, Shannon E. Ronca, Ulrich Strych, Syamala R. Thimmiraju, Leroy Versteeg, Maria Jose Villar-Mondragon, Junfei Wei, Bin Zhan, Maria Elena Bottazzi
Published 2023-12-01

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors

by Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Published 2023-08-01