Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line

by Zhuo-Xun Wu, Yuqi Yang, Leli Zeng, Leli Zeng, Harsh Patel, Letao Bo, Lusheng Lin, Zhe-Sheng Chen
Published 2021-02-01

Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

by Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng, Leli Zeng, Zhe-Sheng Chen
Published 2021-07-01

Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4

by Qiji Li, Qiji Li, Min Wang, Leli Zeng, Leli Zeng, Wei Guo, Yuandong Xu, Chenxin Li, Yingrong Lai, Liping Ye, Liping Ye, Xinsheng Peng
Published 2022-02-01

Editorial: Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers

by Qingbin Cui, Cong Wang, Leli Zeng, Qian-Xiong Zhou, Ying-Fang Fan
Published 2022-05-01

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

by Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Chao-Yun Cai, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Leli Zeng, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen
Published 2018-10-01

Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

by Jingqiu Wang, Jingqiu Wang, Jing-Quan Wang, Chao-Yun Cai, Qingbin Cui, Qingbin Cui, Yuqi Yang, Zhuo-Xun Wu, Xingduo Dong, Leli Zeng, Leli Zeng, Linguo Zhao, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-02-01

Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter

by Hai-Ling Gao, Hai-Ling Gao, Pranav Gupta, Qingbin Cui, Yunali V. Ashar, Zhuo-Xun Wu, Leli Zeng, Leli Zeng, Zi-Ning Lei, Qiu-Xu Teng, Charles R. Ashby, Yingjun Guan, Zhe-Sheng Chen
Published 2020-10-01

Enhanced mild-temperature photothermal therapy by pyroptosis-boosted ATP deprivation with biodegradable nanoformulation

by Kaiyuan Liu, Li Zhang, Hengli Lu, Yingfei Wen, Bo Bi, Guocheng Wang, Yingying Jiang, Leli Zeng, Jing Zhao
Published 2023-02-01

Understanding and targeting resistance mechanisms in cancer

by Zi‐Ning Lei, Qin Tian, Qiu‐Xu Teng, John N. D. Wurpel, Leli Zeng, Yihang Pan, Zhe‐Sheng Chen
Published 2023-06-01

Overexpression of human ATP-binding cassette transporter ABCG2 contributes to reducing the cytotoxicity of GSK1070916 in cancer cells

by Zhuo-Xun Wu, Qiuyan Mai, Yuqi Yang, Jing-Quan Wang, Hansu Ma, Leli Zeng, Zhe-Sheng Chen, Yihang Pan
Published 2021-04-01

Long non-coding RNAs regulate drug resistance in cancer

by Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby, Chang Zou, Zhe-Sheng Chen
Published 2020-03-01

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

by Leli Zeng, B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammed A. S. Abourehab, Zhe-Sheng Chen, Changhua Zhang, Jia Li, Prashant Kesharwani
Published 2023-01-01

Engineering Bifunctional Calcium Alendronate Gene‐Delivery Nanoneedle for Synergistic Chemo/Immuno‐Therapy Against HER2 Positive Ovarian Cancer

by Guochuang Chen, Leli Zeng, Bo Bi, Xiuyu Huang, Miaojuan Qiu, Ping Chen, Zhi‐Ying Chen, Yulong He, Yihang Pan, Yu Chen, Jing Zhao
Published 2023-05-01

Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer

by Huan Yang, Xing Xiao, Leli Zeng, Haiteng Zeng, Yueyuan Zheng, Jingshu Wang, Guanghua Li, Weigang Dai, Yulong He, Suihai Wang, Jianjun Peng, Wei Chen
Published 2024-02-01

Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells

by Xiao-Yu Zhang, Yun-Kai Zhang, Yi-Jun Wang, Pranav Gupta, Leli Zeng, Megan Xu, Xiu-Qi Wang, Dong-Hua Yang, Zhe-Sheng Chen
Published 2016-09-01

Signaling pathways and therapeutic interventions in gastric cancer

by Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng, Yihang Pan, Zhe-Sheng Chen, Yulong He
Published 2022-10-01

Venetoclax, a BCL-2 Inhibitor, Enhances the Efficacy of Chemotherapeutic Agents in Wild-Type ABCG2-Overexpression-Mediated MDR Cancer Cells

by Jing-Quan Wang, Jonathan Y. Li, Qiu-Xu Teng, Zi-Ning Lei, Ning Ji, Qingbin Cui, Leli Zeng, Yihang Pan, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-02-01

Lipid–Saporin Nanoparticles for the Intracellular Delivery of Cytotoxic Protein to Overcome ABC Transporter-Mediated Multidrug Resistance In Vitro and In Vivo

by Guan-Nan Zhang, Pranav Gupta, Ming Wang, Anna Maria Barbuti, Charles R. Ashby, Yun-Kai Zhang, Leli Zeng, Qiaobing Xu, Ying-Fang Fan, Zhe-Sheng Chen
Published 2020-02-01

Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

by Cuncan Deng, Mingyu Huo, Hongwu Chu, Xiaomei Zhuang, Guofei Deng, Wenchao Li, Hongfa Wei, Leli Zeng, Yulong He, Huashan Liu, Jia Li, Changhua Zhang, Hengxing Chen
Published 2024-03-01

Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

by Bo Li, Hui Chen, Shaohua Yang, Feng Chen, Liangliang Xu, Yan Li, Mingzhe Li, Chengming Zhu, Fangyuan Shao, Xinhua Zhang, Chuxia Deng, Leli Zeng, Yulong He, Changhua Zhang
Published 2023-04-01