Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

by Brianna Bibel, Elad Elkayam, Steve Silletti, Elizabeth A Komives, Leemor Joshua-Tor
Published 2022-05-01

The dynamic nature of the human origin recognition complex revealed through five cryoEM structures

by Matt J Jaremko, Kin Fan On, Dennis R Thomas, Bruce Stillman, Leemor Joshua-Tor
Published 2020-08-01

The Making of a Slicer: Activation of Human Argonaute-1

by Christopher R. Faehnle, Elad Elkayam, Astrid D. Haase, Gregory J. Hannon, Leemor Joshua-Tor
Published 2013-06-01

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

by Jonathan J. Ipsaro, Paul A. O’Brien, Shibani Bhattacharya, Arthur G. Palmer, III, Leemor Joshua-Tor
Published 2021-03-01

Structure of the active form of human origin recognition complex and its ATPase motor module

by Ante Tocilj, Kin Fan On, Zuanning Yuan, Jingchuan Sun, Elad Elkayam, Huilin Li, Bruce Stillman, Leemor Joshua-Tor
Published 2017-01-01

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

by Jonathan J Ipsaro, Chen Shen, Eri Arai, Yali Xu, Justin B Kinney, Leemor Joshua-Tor, Christopher R Vakoc, Junwei Shi
Published 2017-01-01

Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression

by Shilpi Paul, Alex Kuo, Thomas Schalch, Hannes Vogel, Leemor Joshua-Tor, W. Richard McCombie, Or Gozani, Molly Hammell, Alea A. Mills
Published 2013-01-01

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

by Navasona Krishnan, Christopher A. Bonham, Ioana A. Rus, Om Kumar Shrestha, Carla M. Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K. Tonks
Published 2018-01-01

Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

by Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
Published 2019-02-01

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

by Pengfei Wang, Lihong Liu, Manoj S. Nair, Michael T. Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J. Purpura, Justin C. Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, David D. Ho
Published 2020-01-01