Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

by Tianhong Su, Doug M. Turnbull, Laura C. Greaves
Published 2018-03-01

Mitochondrial DNA mutations in ageing and cancer

by Anna L. M. Smith, Julia C. Whitehall, Laura C. Greaves
Published 2022-09-01

Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

by Ashwin Sachdeva, Claire A. Hart, Christopher D. Carey, Amy E. Vincent, Laura C. Greaves, Rakesh Heer, Pedro Oliveira, Michael D. Brown, Noel W. Clarke, Doug M. Turnbull
Published 2022-04-01

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutation...

by Laura C Greaves, Joanna L Elson, Marco Nooteboom, John P Grady, Geoffrey A Taylor, Robert W Taylor, John C Mathers, Thomas B L Kirkwood, Doug M Turnbull
Published 2012-01-01

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

by Johanna H.K. Kauppila, Holly L. Baines, Ana Bratic, Marie-Lune Simard, Christoph Freyer, Arnaud Mourier, Craig Stamp, Roberta Filograna, Nils-Göran Larsson, Laura C. Greaves, James B. Stewart
Published 2016-09-01

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

by Craig Stamp, Anze Zupanic, Ashwin Sachdeva, Elizabeth A. Stoll, Daryl P. Shanley, John C. Mathers, Thomas B.L. Kirkwood, Rakesh Heer, Benjamin D. Simons, Doug M. Turnbull, Laura C. Greaves
Published 2018-05-01

Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

by Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker
Published 2022-06-01

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

by Laura C Greaves, Marco Nooteboom, Joanna L Elson, Helen A L Tuppen, Geoffrey A Taylor, Daniel M Commane, Ramesh P Arasaradnam, Konstantin Khrapko, Robert W Taylor, Thomas B L Kirkwood, John C Mathers, Douglass M Turnbull
Published 2014-09-01