Development of a cost effective and robust AlphaScreen® platform for HTS application

by John R Veloria, Ashwini K Devkota, Eun Jeong Cho, Kevin N Dalby
Published 2018-04-01

JNK Signaling in Stem Cell Self-Renewal and Differentiation

by Takashi Semba, Rachel Sammons, Xiaoping Wang, Xuemei Xie, Kevin N. Dalby, Naoto T. Ueno
Published 2020-04-01

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

by Remkes A. Scheele, Laurens H. Lindenburg, Maya Petek, Markus Schober, Kevin N. Dalby, Florian Hollfelder
Published 2022-02-01

Using docking and alchemical free energy perturbation to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

by Qiantao eWang, Ramakrishna eEdupuganti, Clint D. J. Tavares, Kevin N. Dalby, Pengyu eRen
Published 2015-03-01

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

by Sergio Coffa, Maya Breitman, Susan M Hanson, Kari Callaway, Seunghyi Kook, Kevin N Dalby, Vsevolod V Gurevich
Published 2011-01-01

A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach.

by Sunbae Lee, Mangalika Warthaka, Chunli Yan, Tamer S Kaoud, Andrea Piserchio, Ranajeet Ghose, Pengyu Ren, Kevin N Dalby
Published 2011-04-01

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells

by Nicole A. Perry-Hauser, Tamer S. Kaoud, Henriette Stoy, Xuanzhi Zhan, Qiuyan Chen, Kevin N. Dalby, Tina M. Iverson, Vsevolod V. Gurevich, Eugenia V. Gurevich
Published 2022-08-01

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

by Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton
Published 2024-01-01

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer.

by Ibrahim Tekedereli, S Neslihan Alpay, Clint D J Tavares, Zehra E Cobanoglu, Tamer S Kaoud, Ibrahim Sahin, Anil K Sood, Gabriel Lopez-Berestein, Kevin N Dalby, Bulent Ozpolat
Published 2012-01-01

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

by Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie
Published 2018-07-01

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

by Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie
Published 2018-02-01

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

by Heeseog Kang, Amy L. Strong, Yuxiao Sun, Lei Guo, Conan Juan, Alec C. Bancroft, Ji Hae Choi, Chase A. Pagani, Aysel A. Fernandes, Michael Woodard, Juhoon Lee, Sowmya Ramesh, Aaron W. James, David Hudson, Kevin N. Dalby, Lin Xu, Robert J. Tower, Benjamin Levi
Published 2024-03-01

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

by Tamer S. Kaoud, William H. Johnson, Nancy D. Ebelt, Andrea Piserchio, Diana Zamora-Olivares, Sabrina X. Van Ravenstein, Jacey R. Pridgen, Ramakrishna Edupuganti, Rachel Sammons, Micael Cano, Mangalika Warthaka, Matthew Harger, Clint D. J. Tavares, Jihyun Park, Mohamed F. Radwan, Pengyu Ren, Eric V. Anslyn, Kenneth Y. Tsai, Ranajeet Ghose, Kevin N. Dalby
Published 2019-11-01

GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

by Yuan Li, Yibo Fan, Jinbang Xu, Longfei Huo, Ailing W. Scott, Jiankang Jin, Boxuan Yang, Shan Shao, Lang Ma, Ying Wang, Xiaodan Yao, Melissa Pool Pizzi, Matheus Sewastjanow Da Silva, Guoliang Zhang, Lijuan Zhuo, Eun Jeong Cho, Kevin N. Dalby, Namita D. Shanbhag, Zhenning Wang, Wenliang Li, Shumei Song, Jaffer A. Ajani
Published 2022-08-01

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

by Hou-Fu Guo, Neus Bota-Rabassedas, Masahiko Terajima, B. Leticia Rodriguez, Don L. Gibbons, Yulong Chen, Priyam Banerjee, Chi-Lin Tsai, Xiaochao Tan, Xin Liu, Jiang Yu, Michal Tokmina-Roszyk, Roma Stawikowska, Gregg B. Fields, Mitchell D. Miller, Xiaoyan Wang, Juhoon Lee, Kevin N. Dalby, Chad J. Creighton, George N. Phillips, John A. Tainer, Mitsuo Yamauchi, Jonathan M. Kurie
Published 2021-04-01

Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection

by Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Published 2023-10-01

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

by Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
Published 2013-11-01

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

by Rui P Silva, Yimin Huang, Annalee W Nguyen, Ching-Lin Hsieh, Oladimeji S Olaluwoye, Tamer S Kaoud, Rebecca E Wilen, Ahlam N Qerqez, Jun-Gyu Park, Ahmed M Khalil, Laura R Azouz, Kevin C Le, Amanda L Bohanon, Andrea M DiVenere, Yutong Liu, Alison G Lee, Dzifa A Amengor, Sophie R Shoemaker, Shawn M Costello, Eduardo A Padlan, Susan Marqusee, Luis Martinez-Sobrido, Kevin N Dalby, Sheena D'Arcy, Jason S McLellan, Jennifer A Maynard
Published 2023-03-01

Construction of human activity‐based phosphorylation networks

by Robert H Newman, Jianfei Hu, Hee‐Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne‐Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu, Jiang Qian
Published 2013-01-01