STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation

by Joel M. Lee, Mohammed G. Ghonime, Kevin A. Cassady
Published 2019-12-01

The Antiviral Apparatus: STING and Oncolytic Virus Restriction

by Joel Lee, Mohammed G. Ghonime, Ruoning Wang, Kevin A. Cassady
Published 2019-06-01

Spontaneous and Engineered Compensatory HSV Mutants that Counteract the Host Antiviral PKR Response

by Kevin A. Cassady, Masako Shimamura, Amish C. Shah, Jacqueline N. Parker
Published 2009-10-01

Oncolytic Virus-Based Cytokine Expression to Improve Immune Activity in Brain and Solid Tumors

by Taylor M. Pearl, James M. Markert, Kevin A. Cassady, Mohammed G. Ghonime
Published 2019-06-01

Human Herpesviridae Methods of Natural Killer Cell Evasion

by Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady
Published 2012-01-01

Enhanced IL-12 transgene expression improves oncolytic viroimmunotherapy

by Yeaseul Kim, Uksha Saini, Doyeon Kim, Ilse Hernandez-Aguirre, Ilse Hernandez-Aguirre, Ilse Hernandez-Aguirre, Jack Hedberg, Jack Hedberg, Jack Hedberg, Alexia Martin, Alexia Martin, Alexia Martin, Xiaokui Mo, Timothy P. Cripe, Timothy P. Cripe, James Markert, Kevin A. Cassady, Kevin A. Cassady, Kevin A. Cassady, Ravi Dhital
Published 2024-06-01

To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses

by Kevin A. Cassady, Kellie B. Haworth, Josh Jackson, James M. Markert, Timothy P. Cripe
Published 2016-02-01

Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy

by Gregory K Friedman, Joel eRaborn, Virginia M Kelly, Kevin A Cassady, James M Markert, George Yancey Gillespie
Published 2013-02-01

Pre-clinical Assessment of C134, a Chimeric Oncolytic Herpes Simplex Virus, in Mice and Non-human Primates

by Kevin A. Cassady, David F. Bauer, Justin Roth, Melissa R. Chambers, Trent Shoeb, Jennifer Coleman, Mark Prichard, G. Yancey Gillespie, James M. Markert
Published 2017-06-01

Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1.

by David C Gaston, Carl I Odom, Li Li, James M Markert, Justin C Roth, Kevin A Cassady, Richard J Whitley, Jacqueline N Parker
Published 2013-01-01

Chimeric HCMV/HSV-1 and Δγ134.5 oncolytic herpes simplex virus elicit immune mediated antigliomal effect and antitumor memory

by Mohammed G. Ghonime, Josh Jackson, Amish Shah, Justin Roth, Mao Li, Ute Saunders, Jennifer Coleman, G. Yancey Gillespie, James M. Markert, Kevin A. Cassady
Published 2018-02-01

High Mobility Group Box 1 Influences HSV1716 Spread and Acts as an Adjuvant to Chemotherapy

by Leslee Sprague, Joel M. Lee, Brian J. Hutzen, Pin-Yi Wang, Chun-Yu Chen, Joe Conner, Lynne Braidwood, Kevin A. Cassady, Timothy P. Cripe
Published 2018-03-01

Immunotherapeutic Challenges for Pediatric Cancers

by Brian Hutzen, Mohammed Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady
Published 2019-12-01

Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors

by Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Kevin A. Cassady, Timothy P. Cripe, Timothy P. Cripe, Timothy P. Cripe
Published 2024-06-01

Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations

by Payal Aggarwal, Wen Luo, Wen Luo, Katherine C. Pehlivan, Hai Hoang, Prajwal Rajappa, Timothy P. Cripe, Kevin A. Cassady, Dean A. Lee, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo
Published 2022-11-01

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment

by Nicholas L. Denton, Chun-Yu Chen, Brian Hutzen, Mark A. Currier, Thomas Scott, Brooke Nartker, Jennifer L. Leddon, Pin-Yi Wang, Rachelle Srinivas, Kevin A. Cassady, William F. Goins, Timothy P. Cripe
Published 2018-12-01

Eliciting an immune-mediated antitumor response through oncolytic herpes simplex virus-based shared antigen expression in tumors resistant to viroimmunotherapy

by Chun-Yu Chen, Mohammed G Ghonime, Uksha Saini, Michael C Kelly, Justin C Roth, Pin-Yi Wang, Katherine Miller, Ilse Hernandez-Aguirre, Yeaseul Kim, Xiaokui Mo, Joseph R Stanek, Tim Cripe, Elaine Mardis, Kevin A Cassady
Published 2021-10-01

Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution

by Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller
Published 2023-09-01