Radiotherapeutic Strategies to Overcome Resistance of Breast Cancer Brain Metastases by Considering Immunogenic Aspects of Cancer Stem Cells

by Katharina Hintelmann, Cordula Petersen, Kerstin Borgmann
Published 2022-12-01

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

by Alexander Schulz, Felix Meyer, Anna Dubrovska, Kerstin Borgmann
Published 2019-06-01

Molecular Mechanisms Associated with Brain Metastases in HER2-Positive and Triple Negative Breast Cancers

by Sarah Bryan, Isabell Witzel, Kerstin Borgmann, Leticia Oliveira-Ferrer
Published 2021-08-01

Beyond the Double-Strand Breaks: The Role of DNA Repair Proteins in Cancer Stem-Cell Regulation

by Jacqueline Nathansen, Felix Meyer, Luise Müller, Marc Schmitz, Kerstin Borgmann, Anna Dubrovska
Published 2021-09-01

The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner

by Sara Sofia Deville, Anne Vehlow, Sarah Förster, Ellen Dickreuter, Kerstin Borgmann, Nils Cordes
Published 2020-06-01

USP7 Deregulation Impairs S Phase Specific DNA Repair after Irradiation in Breast Cancer Cells

by Marie Vogt, Sandra Classen, Ann Kristin Krause, Nadja-Juanita Peter, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann, Felix Meyer
Published 2024-03-01

Biomarkers and Mechanisms of FANCD2 Function

by Henning Willers, Lisa A. Kachnic, Chen-Mei Luo, Li Li, Martin Purschke, Kerstin Borgmann, Kathryn D. Held, Simon N. Powell
Published 2008-01-01

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner

by Johanna Rieckhoff, Felix Meyer, Sandra Classen, Alexandra Zielinski, Britta Riepen, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann, Ann Christin Parplys
Published 2020-09-01

DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients

by Ioan T. Bold, Ann-Kathrin Specht, Conrad F. Droste, Alexandra Zielinski, Felix Meyer, Till S. Clauditz, Adrian Münscher, Stefan Werner, Kai Rothkamm, Cordula Petersen, Kerstin Borgmann
Published 2021-03-01

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

by Felix Meyer, Saskia Becker, Sandra Classen, Ann Christin Parplys, Wael Yassin Mansour, Britta Riepen, Sara Timm, Claudia Ruebe, Maria Jasin, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann
Published 2020-01-01

Efficient DNA Repair Mitigates Replication Stress Resulting in Less Immunogenic Cytosolic DNA in Radioresistant Breast Cancer Stem Cells

by Felix Meyer, Anna Maria Engel, Ann Kristin Krause, Tim Wagner, Lena Poole, Anna Dubrovska, Anna Dubrovska, Claudia Peitzsch, Claudia Peitzsch, Claudia Peitzsch, Kai Rothkamm, Cordula Petersen, Kerstin Borgmann
Published 2022-02-01

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

by Lynnette Marcar, Kankana Bardhan, Liliana Gheorghiu, Patrick Dinkelborg, Heike Pfäffle, Qi Liu, Meng Wang, Zofia Piotrowska, Lecia V. Sequist, Kerstin Borgmann, Jeffrey E. Settleman, Jeffrey A. Engelman, Aaron N. Hata, Henning Willers
Published 2019-06-01

Targeting the DNA replication stress phenotype of KRAS mutant cancer cells

by Tara Al Zubaidi, O. H. Fiete Gehrisch, Marie-Michelle Genois, Qi Liu, Shan Lu, Jong Kung, Yunhe Xie, Jan Schuemann, Hsiao-Ming Lu, Aaron N. Hata, Lee Zou, Kerstin Borgmann, Henning Willers
Published 2021-02-01

Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

by Sandra Classen, Elena Rahlf, Johannes Jungwirth, Nina Albers, Luca Philipp Hebestreit, Alexandra Zielinski, Lena Poole, Marco Groth, Philipp Koch, Thomas Liehr, Stefanie Kankel, Nils Cordes, Cordula Petersen, Kai Rothkamm, Helmut Pospiech, Kerstin Borgmann
Published 2022-11-01

Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

by Joanna Kempska, Leticia Oliveira-Ferrer, Astrid Grottke, Minyue Qi, Malik Alawi, Felix Meyer, Kerstin Borgmann, Fabienne Hamester, Kathrin Eylmann, Maila Rossberg, Daniel J. Smit, Manfred Jücker, Elena Laakmann, Isabell Witzel, Barbara Schmalfeldt, Volkmar Müller, Karen Legler
Published 2023-07-01

Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.

by Corina Penterling, Guido A Drexler, Claudia Böhland, Ramona Stamp, Christina Wilke, Herbert Braselmann, Randolph B Caldwell, Judith Reindl, Stefanie Girst, Christoph Greubel, Christian Siebenwirth, Wael Y Mansour, Kerstin Borgmann, Günther Dollinger, Kristian Unger, Anna A Friedl
Published 2016-01-01

Clonality of circulating tumor cells in breast cancer brain metastasis patients

by Carlotta Riebensahm, Simon A. Joosse, Malte Mohme, Annkathrin Hanssen, Jakob Matschke, Yvonne Goy, Isabell Witzel, Katrin Lamszus, Jolanthe Kropidlowski, Cordula Petersen, Anja Kolb-Kokocinski, Sascha Sauer, Kerstin Borgmann, Markus Glatzel, Volkmar Müller, Manfred Westphal, Sabine Riethdorf, Klaus Pantel, Harriet Wikman
Published 2019-09-01

Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative bre...

by Simon Gehre, Simon Gehre, Simon Gehre, Felix Meyer, Azzaya Sengedorj, Azzaya Sengedorj, Azzaya Sengedorj, Fridolin Grottker, Fridolin Grottker, Fridolin Grottker, Clara M. Reichardt, Clara M. Reichardt, Clara M. Reichardt, Jannik Alomo, Jannik Alomo, Jannik Alomo, Kerstin Borgmann, Benjamin Frey, Benjamin Frey, Benjamin Frey, Rainer Fietkau, Rainer Fietkau, Michael Rückert, Michael Rückert, Michael Rückert, Udo S. Gaipl, Udo S. Gaipl, Udo S. Gaipl
Published 2023-04-01

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

by Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Published 2020-09-01

Hierarchy of Nonhomologous End-joining, Single-strand Annealing and Gene Conversion at Site-directed DNA Double-strand Breaks

by Mansour, Wael Y., Schumacher, Sabine, Rosskopf, Raphael, Rhein, Tim, Schmidt-Petersen, Filip, Gatzemeier, Fruszina, Haag, Friedrich, Borgmann, Kerstin, Willers, Henning, Dahm-Daphi, Jochen
Published 2011