Viral and Cellular Requirements for the Nuclear Entry of Retroviral Preintegration Nucleoprotein Complexes

by Alan Engelman, Kenneth A. Matreyek
Published 2013-10-01

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.

by Kenneth A Matreyek, Sara S Yücel, Xiang Li, Alan Engelman
Published 2013-01-01

Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

by Kenneth A. Matreyek, Jason J. Stephany, Ethan Ahler, Douglas M. Fowler
Published 2021-10-01

Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains.

by Sarah M Roelle, Nidhi Shukla, Anh T Pham, Anna M Bruchez, Kenneth A Matreyek
Published 2022-07-01

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.

by Nidhi Shukla, Sarah M Roelle, Vinicius G Suzart, Anna M Bruchez, Kenneth A Matreyek
Published 2021-07-01

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage.

by Nidhi Shukla, Sarah M Roelle, John C Snell, Olivia DelSignore, Anna M Bruchez, Kenneth A Matreyek
Published 2024-05-01

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

by Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A. Matreyek, Douglas M. Fowler, Vincenzo Carnevale, Chad L. Myers, Daniel Schmidt
Published 2021-12-01

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

by Timothy J. C. Tan, Zongjun Mou, Ruipeng Lei, Wenhao O. Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A. Wilson, Collin Kieffer, Xinghong Dai, Kenneth A. Matreyek, Nicholas C. Wu
Published 2023-04-01

Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2

by Ariana Ghez Farrell, Bernadeta Dadonaite, Allison J. Greaney, Rachel Eguia, Andrea N. Loes, Nicholas M. Franko, Jennifer Logue, Juan Manuel Carreño, Anass Abbad, Helen Y. Chu, Kenneth A. Matreyek, Jesse D. Bloom
Published 2022-09-01

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

by Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler
Published 2020-09-01

High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology

by Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Zerubabell A. Daniel, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Published 2024-05-01