Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

by Elena Puris, Liudmila Saveleva, Seppo Auriola, Mikko Gynther, Katja M. Kanninen, Gert Fricker
Published 2024-03-01

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

by Moataz Abdalkader, Riikka Lampinen, Katja M. Kanninen, Tarja M. Malm, Jeffrey R. Liddell
Published 2018-07-01

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

by Elena Puris, Aaro Jalkanen, Seppo Auriola, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, Mikko Gynther
Published 2022-06-01

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

by Arto Alatalo, Izaque de Sousa Maciel, Nina Kucháriková, Sweelin Chew, Irene van Kamp, Maria Foraster, Jordi Julvez, Katja M. Kanninen
Published 2023-03-01

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

by Elena Puris, Štěpán Kouřil, Lukáš Najdekr, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, David Friedecký, Mikko Gynther
Published 2021-06-01

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

by Mikko Gynther, Mariana Leal Estrada, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, Seppo Auriola, Gert Fricker, Elena Puris
Published 2022-11-01

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

by Hiramani Dhungana, Mikko T. Huuskonen, Merja Jaronen, Sighild Lemarchant, Humair Ali, Velta Keksa-Goldsteine, Gundars Goldsteins, Katja M. Kanninen, Jari Koistinaho, Tarja Malm
Published 2017-12-01

Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework

by Muhammad Ali Shahbaz, Francesca De Bernardi, Arto Alatalo, Magdalini Sachana, Laure-Alix Clerbaux, Amalia Muñoz, Surat Parvatam, Brigitte Landesmann, Katja M. Kanninen, Sandra Coecke
Published 2022-09-01

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

by Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm
Published 2019-06-01

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

by Katja M. Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J. Parker, Grace E. Lidgerwood, Irene Volitakis, George Ganio, Peter J. Crouch, Anthony R. White
Published 2013-05-01

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

by Henri Leinonen, Velta Keksa-Goldsteine, Symantas Ragauskas, Philip Kohlmann, Yajuvinder Singh, Ekaterina Savchenko, Jooseppi Puranen, Tarja Malm, Giedrius Kalesnykas, Jari Koistinaho, Heikki Tanila, Katja M. Kanninen
Published 2017-05-01

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

by Irina Belaya, Nina Kucháriková, Veronika Górová, Kai Kysenius, Dominic J. Hare, Peter J. Crouch, Tarja Malm, Mustafa Atalay, Anthony R. White, Jeffrey R. Liddell, Katja M. Kanninen
Published 2021-08-01

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease

by Irina Belaya, Mariia Ivanova, Annika Sorvari, Marina Ilicic, Sanna Loppi, Hennariikka Koivisto, Alessandra Varricchio, Heikki Tikkanen, Frederick R. Walker, Mustafa Atalay, Tarja Malm, Alexandra Grubman, Heikki Tanila, Katja M. Kanninen
Published 2020-09-01

Proteomic insights into mental health status: plasma markers in young adults

by Alexey M. Afonin, Aino-Kaisa Piironen, Izaque de Sousa Maciel, Mariia Ivanova, Arto Alatalo, Alyce M. Whipp, Lea Pulkkinen, Richard J. Rose, Irene van Kamp, Jaakko Kaprio, Katja M. Kanninen
Published 2024-01-01

Development of Lyophilised Eudragit^® Retard Nanoparticles for the Sustained Release of Clozapine via Intranasal Administration

by Rosamaria Lombardo, Marika Ruponen, Jarkko Rautio, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Laura Calosi, Daniele Bani, Riikka Lampinen, Katja M. Kanninen, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Rosario Pignatello
Published 2023-05-01

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

by Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Kärkkäinen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R. White, Tarja Malm, Jari Koistinaho, Katja M. Kanninen
Published 2017-09-01

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

by Sarah J Parker, Jodi Meyerowitz, Janine L James, Jeffrey R Liddell, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, SinChun Lim, Brett M Paterson, Paul S Donnelly, Peter J Crouch, Anthony R White
Published 2012-01-01

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

by Diane Moujalled, Janine L James, Sarah J Parker, Grace E Lidgerwood, Clare Duncan, Jodi Meyerowitz, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, Alexandra Grubman, Jeffrey R Liddell, Peter J Crouch, Anthony R White
Published 2013-01-01

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

by Stefano Doccini, Maria Marchese, Federica Morani, Nicola Gammaldi, Serena Mero, Francesco Pezzini, Rabah Soliymani, Melissa Santi, Giovanni Signore, Asahi Ogi, Silvia Rocchiccioli, Katja M. Kanninen, Alessandro Simonati, Maciej M. Lalowski, Filippo M. Santorelli
Published 2022-06-01

Particulate matter from car exhaust alters function of human iPSC-derived microglia

by Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm, Paula Korhonen
Published 2024-02-01