Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

by Birte Arlt, Guido Mastrobuoni, Jasmin Wuenschel, Kathy Astrahantseff, Angelika Eggert, Stefan Kempa, Hedwig E. Deubzer
Published 2021-01-01

Discovery of Spatial Peptide Signatures for Neuroblastoma Risk Assessment by MALDI Mass Spectrometry Imaging

by Zhiyang Wu, Patrick Hundsdoerfer, Johannes H. Schulte, Kathy Astrahantseff, Senguel Boral, Karin Schmelz, Angelika Eggert, Oliver Klein
Published 2021-06-01

Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

by Anton Gauert, Nadine Olk, Helia Pimentel-Gutiérrez, Kathy Astrahantseff, Lasse D. Jensen, Yihai Cao, Angelika Eggert, Cornelia Eckert, Anja I.H. Hagemann
Published 2020-07-01

Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis

by Ornela Sulejmani, Laura Grunewald, Lena Andersch, Silke Schwiebert, Anika Klaus, Annika Winkler, Kathy Astrahantseff, Angelika Eggert, Anton G. Henssen, Johannes H. Schulte, Kathleen Anders, Annette Künkele
Published 2021-10-01

GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma

by Annette Künkele, Angelika Eggert, Johannes H Schulte, Anika Klaus, Horst Lindhofer, Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Silke Schwiebert, Peter Ruf, Kathy Astrahantseff, Lena Andersch, Holger N Lode, Kathleen Anders, Patrick Hundsdoerfer
Published 2021-07-01

Circulating Cell-Free DNA Assessment in Biofluids from Children with Neuroblastoma Demonstrates Feasibility and Potential for Minimally Invasive Molecular Diagnostics

by Marco Lodrini, Jasmin Wünschel, Theresa M. Thole-Kliesch, Maddalena Grimaldi, Annika Sprüssel, Rasmus B. Linke, Jan F. Hollander, Daniela Tiburtius, Annette Künkele, Johannes H. Schulte, Erwin Lankes, Thomas Elgeti, Patrick Hundsdörfer, Kathy Astrahantseff, Thorsten Simon, Angelika Eggert, Hedwig E. Deubzer
Published 2022-04-01

Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

by Karin Schmelz, Joern Toedling, Matt Huska, Maja C. Cwikla, Louisa-Marie Kruetzfeldt, Jutta Proba, Peter F. Ambros, Inge M. Ambros, Sengül Boral, Marco Lodrini, Celine Y. Chen, Martin Burkert, Dennis Guergen, Annabell Szymansky, Kathy Astrahantseff, Annette Kuenkele, Kerstin Haase, Matthias Fischer, Hedwig E. Deubzer, Falk Hertwig, Patrick Hundsdoerfer, Anton G. Henssen, Roland F. Schwarz, Johannes H. Schulte, Angelika Eggert
Published 2021-11-01

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

by Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte
Published 2023-07-01

A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization

by Laura Grunewald, Laura Grunewald, Tobias Lam, Tobias Lam, Lena Andersch, Anika Klaus, Silke Schwiebert, Annika Winkler, Anton Gauert, Anja I. Heeren-Hagemann, Kathy Astrahantseff, Filippos Klironomos, Alexander Thomas, Alexander Thomas, Hedwig E. Deubzer, Hedwig E. Deubzer, Hedwig E. Deubzer, Hedwig E. Deubzer, Anton G. Henssen, Anton G. Henssen, Angelika Eggert, Angelika Eggert, Angelika Eggert, Angelika Eggert, Johannes H. Schulte, Johannes H. Schulte, Johannes H. Schulte, Kathleen Anders, Kathleen Anders, Lutz Kloke, Lutz Kloke, Annette Künkele, Annette Künkele, Annette Künkele, Annette Künkele
Published 2021-06-01