The Therapeutic Potential of Metformin in Neurodegenerative Diseases

by Carola Rotermund, Gerrit Machetanz, Julia C. Fitzgerald, Julia C. Fitzgerald
Published 2018-07-01

Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons

by Lisa Schwarz, Julia C. Fitzgerald
Published 2022-04-01

Generation of R272Q, S156A and K572R RHOT1/Miro1 point mutations in iPSCs from a healthy individual using FACS-assisted CRISPR/Cas9 genome editing

by Lisa Schwarz, Nicolas Casadei, Julia C. Fitzgerald
Published 2021-08-01

Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons

by Lisa Schwarz, Karan Sharma, Lorenzo D. Dodi, Lara-Sophie Rieder, Petra Fallier-Becker, Nicolas Casadei, Nicolas Casadei, Julia C. Fitzgerald
Published 2022-12-01

Mitochondrial Dysfunction in Spinocerebellar Ataxia Type 3 Is Linked to VDAC1 Deubiquitination

by Tina Harmuth, Jonasz J. Weber, Anna J. Zimmer, Anna S. Sowa, Jana Schmidt, Julia C. Fitzgerald, Ludger Schöls, Olaf Riess, Jeannette Hübener-Schmid
Published 2022-05-01

Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation

by Aslihan Ugun-Klusek, Theodosis S. Theodosi, Julia C. Fitzgerald, Florence Burté, Christoph Ufer, David J. Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E. Ellen Billett
Published 2019-01-01

Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction

by Ricarda Breitmeyer, Sabrina Vogel, Johanna Heider, Sophia-Marie Hartmann, Richard Wüst, Anna-Lena Keller, Anna Binner, Julia C. Fitzgerald, Andreas J. Fallgatter, Hansjürgen Volkmer
Published 2023-04-01

Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy

by Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, Julia C. Fitzgerald, Stefan Geimer, Benedikt Westermann, Boris Macek, Philipp J. Kahle
Published 2022-12-01

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

by Sarah J. Brown, Ibrahim Boussaad, Javier Jarazo, Julia C. Fitzgerald, Paul Antony, Marcus Keatinge, Janna Blechman, Jens C. Schwamborn, Rejko Krüger, Marysia Placzek, Oliver Bandmann
Published 2021-03-01

TGF-Beta Modulates the Integrity of the Blood Brain Barrier In Vitro, and Is Associated with Metabolic Alterations in Pericytes

by Leonie Schumacher, Rédouane Slimani, Laimdota Zizmare, Jakob Ehlers, Felix Kleine Borgmann, Julia C. Fitzgerald, Petra Fallier-Becker, Anja Beckmann, Alexander Grißmer, Carola Meier, Ali El-Ayoubi, Kavi Devraj, Michel Mittelbronn, Christoph Trautwein, Ulrike Naumann
Published 2023-01-01

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

by Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit
Published 2022-01-01

Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

by Christine Bus, Laimdota Zizmare, Marita Feldkaemper, Sven Geisler, Maria Zarani, Anna Schaedler, Franziska Klose, Jakob Admard, Craig J. Mageean, Giuseppe Arena, Petra Fallier-Becker, Aslihan Ugun-Klusek, Klaudia K. Maruszczak, Konstantina Kapolou, Benjamin Schmid, Doron Rapaport, Marius Ueffing, Nicolas Casadei, Rejko Krüger, Thomas Gasser, Daniela M. Vogt Weisenhorn, Philipp J. Kahle, Christoph Trautwein, Christian J. Gloeckner, Julia C. Fitzgerald
Published 2020-12-01

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

by Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Published 2022-08-01