Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders

by Yi-Zhi Wang, Jeffrey N. Savas
Published 2018-07-01

Derailed protein turnover in the aging mammalian brain

by Nalini R Rao, Arun Upadhyay, Jeffrey N Savas
Published 2024-01-01

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

by David R. Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey N. Savas
Published 2020-09-01

Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry

by Pan Liu, Seby Louis Edassery, Laith Ali, Benjamin R Thomson, Jeffrey N Savas, Jing Jin
Published 2019-12-01

Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex.

by Paolo Mita, Jeffrey N Savas, Susan Ha, Nabil Djouder, John R Yates, Susan K Logan
Published 2013-01-01

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

by Arun Upadhyay, Deepak Chhangani, Nalini R. Rao, Julia Kofler, Robert Vassar, Diego E. Rincon-Limas, Jeffrey N. Savas
Published 2023-09-01

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication

by Yi-Zhi Wang, Charlotte C.M. Castillon, Kamil K. Gebis, Elizabeth T. Bartom, Alessandra d’Azzo, Anis Contractor, Jeffrey N. Savas
Published 2024-02-01

Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome

by Sehyoun Yoon, Marc Dos Santos, Marc P. Forrest, Christopher P. Pratt, Natalia Khalatyan, Peter J. Mohler, Jeffrey N. Savas, Peter Penzes
Published 2023-07-01

Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins

by Carlos Cardanho-Ramos, Rúben Alves Simões, Yi-Zhi Wang, Andreia Faria-Pereira, Ewa Bomba-Warczak, Katleen Craessaerts, Marco Spinazzi, Jeffrey N. Savas, Vanessa A. Morais
Published 2024-04-01

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

by Jean J Kim, Jeffrey N Savas, Meghan T Miller, Xindao Hu, Cassiano Carromeu, Mathieu Lavallée-Adam, Beatriz C G Freitas, Alysson R Muotri, John R Yates, Anirvan Ghosh
Published 2019-01-01

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

by Natalie F. Shanks, Jeffrey N. Savas, Tomohiko Maruo, Ondrej Cais, Atsushi Hirao, Souichi Oe, Anirvan Ghosh, Yasuko Noda, Ingo H. Greger, John R. Yates, III, Terunaga Nakagawa
Published 2012-06-01

Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3

by Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Published 2022-08-01

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

by Nuno Apóstolo, Samuel N. Smukowski, Jeroen Vanderlinden, Giuseppe Condomitti, Vasily Rybakin, Jolijn ten Bos, Laura Trobiani, Sybren Portegies, Kristel M. Vennekens, Natalia V. Gounko, Davide Comoletti, Keimpe D. Wierda, Jeffrey N. Savas, Joris de Wit
Published 2020-10-01

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

by Matthew Wortham, Jacqueline R. Benthuysen, Martina Wallace, Jeffrey N. Savas, Francesca Mulas, Ajit S. Divakaruni, Fenfen Liu, Verena Albert, Brandon L. Taylor, Yinghui Sui, Enrique Saez, Anne N. Murphy, John R. Yates, III, Christian M. Metallo, Maike Sander
Published 2018-12-01

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

by Ryo Yonashiro, Erich B Tahara, Mario H Bengtson, Maria Khokhrina, Holger Lorenz, Kai-Chun Chen, Yu Kigoshi-Tansho, Jeffrey N Savas, John R Yates III, Steve A Kay, Elizabeth A Craig, Axel Mogk, Bernd Bukau, Claudio AP Joazeiro
Published 2016-03-01

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

by David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Published 2019-08-01

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

by Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Published 2023-02-01

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

by Jeffrey N. Savas, Yi-Zhi Wang, Laura A. DeNardo, Salvador Martinez-Bartolome, Daniel B. McClatchy, Timothy J. Hark, Natalie F. Shanks, Kira A. Cozzolino, Mathieu Lavallée-Adam, Samuel N. Smukowski, Sung Kyu Park, Jeffery W. Kelly, Edward H. Koo, Terunaga Nakagawa, Eliezer Masliah, Anirvan Ghosh, John R. Yates, III
Published 2017-11-01

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy

by Sandra Donkervoort, Niklas Krause, Mykola Dergai, Pomi Yun, Judith Koliwer, Svetlana Gorokhova, Janelle Geist Hauserman, Beryl B Cummings, Ying Hu, Rosemarie Smith, Prech Uapinyoying, Vijay S Ganesh, Partha S Ghosh, Kristin G Monaghan, Seby L Edassery, Pia E Ferle, Sarah Silverstein, Katherine R Chao, Molly Snyder, Sara Ellingwood, Diana Bharucha‐Goebel, Susan T Iannaccone, Matteo Dal Peraro, A Reghan Foley, Jeffrey N Savas, Véronique Bolduc, Dirk Fasshauer, Carsten G Bönnemann, Michael Schwake
Published 2021-12-01

Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway

by Jeong, Hyunkyung, Cohen, Dena E., Cui, Libin, Supinski, Andrea, Savas, Jeffrey N., Mazzulli, Joseph R, Yates, John R., Bordone, Laura, Guarente, Leonard, Krainc, Dimitri
Published 2013