A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone

by Rukaia Almshayakhchi, Rukaia Almshayakhchi, Divya Nagarajan, Divya Nagarajan, Jayakumar Vadakekolathu, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, A. Graham Pockley, Lindy Durrant, Stephanie McArdle, Stephanie McArdle
Published 2021-06-01

S129: ADOPTIVELY INFUSED MEMORY-LIKE (ML) NATURAL KILLER (NK) CELLS ELICIT ADAPTIVE IMMUNE RESPONSES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML)

by Sergio Rutella, Amanda Cashen, John Muth, Jayakumar Vadakekolathu, Laura Arthur, Nitin Mahajan, Melissa Berrien-Elliott, Jan Davidson-Moncada, Todd Fehniger
Published 2023-08-01

A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8⁺ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice

by Pauline Le Vu, Jayakumar Vadakekolathu, Sarra Idri, Holly Nicholls, Manon Cavaignac, Stephen Reeder, Masood A. Khan, Dennis Christensen, Alan Graham Pockley, Stéphanie E. McArdle
Published 2022-04-01

Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy

by Jayakumar Vadakekolathu, David J. Boocock, Kirti Pandey, Barbara-ann Guinn, Antoine Legrand, Amanda K. Miles, Clare Coveney, Rochelle Ayala, Anthony W. Purcell, Stephanie E. McArdle
Published 2022-08-01

Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interfe...

by Raquel Alves, Stephanie E. B. McArdle, Jayakumar Vadakekolathu, Ana Cristina Gonçalves, Paulo Freitas-Tavares, Amélia Pereira, Antonio M. Almeida, Ana Bela Sarmento-Ribeiro, Sergio Rutella
Published 2020-01-01

Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines

by Adeola Grace Atobatele, Elisa Tonoli, Jayakumar Vadakekolathu, Maria Pia Savoca, Melissa Barr, Yukti Kataria, Marta Rossanese, Izhar Burhan, Stephanie McArdle, Daniela Caccamo, Elisabetta A. M. Verderio
Published 2023-05-01

PYK2 promotes HER2-positive breast cancer invasion

by Shaymaa IK. Al-Juboori, Jayakumar Vadakekolathu, Sarra Idri, Sarah Wagner, Dimitrios Zafeiris, Joshua RD. Pearson, Rukaia Almshayakhchi, Michele Caraglia, Vincenzo Desiderio, Amanda K. Miles, David J. Boocock, Graham R. Ball, Tarik Regad
Published 2019-05-01

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse...

by Gemma A. Foulds, Jayakumar Vadakekolathu, Tarek M. A. Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M. Moseley, Stephen Y. T. Chan, A. Graham Pockley, Sergio Rutella, Stephanie E. B. McArdle
Published 2018-09-01

A Proteomic Approach Reveals That miR-423-5p Modulates Glucidic and Amino Acid Metabolism in Prostate Cancer Cells

by Amalia Luce, Angela Lombardi, Carmela Ferri, Silvia Zappavigna, Madhura S. Tathode, Amanda K. Miles, David J. Boocock, Jayakumar Vadakekolathu, Marco Bocchetti, Roberto Alfano, Rossella Sperlongano, Angela Ragone, Luigi Sapio, Vincenzo Desiderio, Silvio Naviglio, Tarik Regad, Michele Caraglia
Published 2022-12-01

MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer

by Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Published 2022-01-01

IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer

by Claudia Tulotta, Diane V. Lefley, Charlotte K. Moore, Ana E. Amariutei, Amy R. Spicer-Hadlington, Lewis A. Quayle, Russell O. Hughes, Khawla Ahmed, Victoria Cookson, Catherine A. Evans, Jayakumar Vadakekolathu, Paul Heath, Sheila Francis, Emmanuel Pinteaux, A. Graham Pockley, Penelope D. Ottewell
Published 2021-07-01

Gene Expression Profiling of FFPE Samples: A Titration Test

by Harshitha Shobha Manjunath MSc, Moza Al Khulaifi BSc, Heba Sidahmed MD, Adham Ammar MD, Jayakumar Vadakekolathu PhD, Sergio Rutella MD, Muneera Jassim Al-Mohannadi MD, Mamoun Elawad MD, William Mifsud MD, Adrian Charles MD, Cristina Maccalli PhD, Sara Tomei PhD
Published 2022-11-01

Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness

by Maria Hatziapostolou, Marina Koutsioumpa, Abed M. Zaitoun, Christos Polytarchou, Mouad Edderkaoui, Swapna Mahurkar-Joshi, Jayakumar Vadakekolathu, Daniel D'Andrea, Anna Rose Lay, Niki Christodoulou, Thuy Pham, Tung-On Yau, Christina Vorvis, Suchit Chatterji, Stephen J. Pandol, George A. Poultsides, David W. Dawson, Dileep N. Lobo, Dimitrios Iliopoulos
Published 2024-01-01

Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia

by Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Bruce R. Blazar, Vedran Radojcic, Joshua F. Zeidner, Andrea Arruda, Bofei Wang, Hussein A. Abbas, Mark D. Minden, Sarah K. Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Published 2022-11-01

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthrit...

by Qiao Zhou, Qiao Zhou, Qiao Zhou, Jayakumar Vadakekolathu, Abdulla Watad, Kassem Sharif, Tobias Russell, Hannah Rowe, Almas Khan, Peter A. Millner, Peter Loughenbury, Abhay Rao, Robert Dunsmuir, Jake Timothy, Giovanni Damiani, Giovanni Damiani, Paolo D. M. Pigatto, Paolo D. M. Pigatto, Piergiorgio Malagoli, Giuseppe Banfi, Yasser M. El-Sherbiny, Charlie Bridgewood, Dennis McGonagle, Dennis McGonagle
Published 2021-04-01