Membrane thinning and lateral gating are consistent features of BamA across multiple species.

by Jinchan Liu, James C Gumbart
Published 2020-10-01

Escherichia coli peptidoglycan structure and mechanics as predicted by atomic-scale simulations.

by James C Gumbart, Morgan Beeby, Grant J Jensen, Benoît Roux
Published 2014-02-01

Toward a 3D physical model of diffusive polymer chains

by Andras Karsai, Grace J. Cassidy, Aradhya P. Rajanala, Lixinhao Yang, Deniz Kerimoglu, James C. Gumbart, James C. Gumbart, Harold D. Kim, Daniel I. Goldman
Published 2023-06-01

Folding and Insertion of Transmembrane Helices at the ER

by Paul Whitley, Brayan Grau, James C. Gumbart, Luis Martínez-Gil, Ismael Mingarro
Published 2021-11-01

SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

by Yui Tik Pang, Atanu Acharya, Diane L. Lynch, Anna Pavlova, James C. Gumbart
Published 2022-11-01

Structural insight into toxin secretion by contact-dependent growth inhibition transporters

by Jeremy Guerin, Istvan Botos, Zijian Zhang, Karl Lundquist, James C Gumbart, Susan K Buchanan
Published 2020-10-01

The Role of Extracellular Loops in the Folding of Outer Membrane Protein X (OmpX) of Escherichia coli

by Simen Hermansen, David Ryoo, Marcella Orwick-Rydmark, Athanasios Saragliadis, James C. Gumbart, Dirk Linke
Published 2022-07-01

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

by Kevin Wu, Samuel Itskanov, Diane L. Lynch, Yuanyuan Chen, Aasha Turner, James C. Gumbart, Eunyong Park
Published 2024-03-01

Transmembrane but not soluble helices fold inside the ribosome tunnel

by Manuel Bañó-Polo, Carlos Baeza-Delgado, Silvia Tamborero, Anthony Hazel, Brayan Grau, IngMarie Nilsson, Paul Whitley, James C. Gumbart, Gunnar von Heijne, Ismael Mingarro
Published 2018-12-01

Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM

by Runrun Wu, Jeremy W. Bakelar, Karl Lundquist, Zijian Zhang, Katie M. Kuo, David Ryoo, Yui Tik Pang, Chen Sun, Tommi White, Thomas Klose, Wen Jiang, James C. Gumbart, Nicholas Noinaj
Published 2021-12-01

Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein

by Benjamin Russell Lewis, Muhammad R. Uddin, Mohammad Moniruzzaman, Katie M. Kuo, Anna J. Higgins, Laila M. N. Shah, Frank Sobott, Jerry M. Parks, Dietmar Hammerschmid, James C. Gumbart, Helen I. Zgurskaya, Eamonn Reading
Published 2023-07-01

Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller

by Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Published 2024-01-01

Quantifying arrhythmic long QT effects of hydroxychloroquine and azithromycin with whole-heart optical mapping and simulations

by Ilija Uzelac, PhD, MBA, Abouzar Kaboudian, PhD, Shahriar Iravanian, MD, MSE, Jimena G. Siles-Paredes, MSc, James C. Gumbart, PhD, Hiroshi Ashikaga, MD, PhD, Neal Bhatia, MD, FHRS, Robert F. Gilmour, Jr., PhD, Elizabeth M. Cherry, PhD, Flavio H. Fenton, PhD
Published 2021-08-01

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

by C. Coral Domínguez-Medina, Marisol Pérez-Toledo, Anna E. Schager, Jennifer L. Marshall, Charlotte N. Cook, Saeeda Bobat, Hyea Hwang, Byeong Jae Chun, Erin Logan, Jack A. Bryant, Will M. Channell, Faye C. Morris, Sian E. Jossi, Areej Alshayea, Amanda E. Rossiter, Paul A. Barrow, William G. Horsnell, Calman A. MacLennan, Ian R. Henderson, Jeremy H. Lakey, James C. Gumbart, Constantino López-Macías, Vassiliy N. Bavro, Adam F. Cunningham
Published 2020-02-01

Structure of the SecY channel during initiation of protein translocation

by Park, Eunyong, Ménétret, Jean-François, Gumbart, James C., Ludtke, Steven J., Li, Weikai, Whynot, Andrew, Rapoport, Tom A., Akey, Christopher W.
Published 2014