MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors a...

by Jiri Neuzil, Jakub Rohlena, Lukas Werner, Zuzana Bielcikova
Published 2023-09-01

Mitochondrial complex II and reactive oxygen species in disease and therapy

by Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena
Published 2020-01-01

Effects of metabolic cancer therapy on tumor microenvironment

by Petra Hyroššová, Mirko Milošević, Mirko Milošević, Josef Škoda, Jiří Vachtenheim Jr, Jakub Rohlena, Kateřina Rohlenová
Published 2022-12-01

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

by Verena Henrichs, Lenka Grycova, Cyril Barinka, Zuzana Nahacka, Jiri Neuzil, Stefan Diez, Jakub Rohlena, Marcus Braun, Zdenek Lansky
Published 2020-06-01

High molecular weight forms of mammalian respiratory chain complex II.

by Nikola Kovářová, Tomáš Mráček, Hana Nůsková, Eliška Holzerová, Marek Vrbacký, Petr Pecina, Kateřina Hejzlarová, Katarína Kľučková, Jakub Rohlena, Jiri Neuzil, Josef Houštěk
Published 2013-01-01

Shikonin impairs mitochondrial activity to selectively target leukemia cells

by Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Julie A. Reisz, Angelo D'Alessandro, Jakub Rohlena, Paul A. Spagnuolo
Published 2022-08-01

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

by Zora Novakova, Mirko Milosevic, Zsofia Kutil, Marketa Ondrakova, Barbora Havlinova, Petr Kasparek, Cristian Sandoval-Acuña, Zuzana Korandova, Jaroslav Truksa, Marek Vrbacky, Jakub Rohlena, Cyril Barinka
Published 2022-10-01

Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners

by Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova, Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova, Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K. Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini, T. M. Iverson
Published 2024-01-01

Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trialResearch in context

by Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Published 2023-03-01

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

by Ayenachew Bezawork-Geleta, He Wen, LanFeng Dong, Bing Yan, Jelena Vider, Stepana Boukalova, Linda Krobova, Katerina Vanova, Renata Zobalova, Margarita Sobol, Pavel Hozak, Silvia Magalhaes Novais, Veronika Caisova, Pavel Abaffy, Ravindra Naraine, Ying Pang, Thiri Zaw, Ping Zhang, Radek Sindelka, Mikael Kubista, Steven Zuryn, Mark P. Molloy, Michael V. Berridge, Karel Pacak, Jakub Rohlena, Sunghyouk Park, Jiri Neuzil
Published 2018-06-01

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

by Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Hozak, Alfred K Lam, Radislav Sedlacek, Paulo J Oliveira, Mikael Kubista, Anurag Agrawal, Katerina Dvorakova-Hortova, Jakub Rohlena, Michael V Berridge, Jiri Neuzil
Published 2017-02-01