The Glyoxalase System—New Insights into an Ancient Metabolism

by Jakob Morgenstern, Marta Campos Campos, Peter Nawroth, Thomas Fleming
Published 2020-10-01

Michaelis-Menten Kinetics Measurements of Aldo-Keto Reductases for Various Substrates in Murine Tissue

by Jakob Morgenstern, Elisabeth Kliemank, Marta Campos Campos, Peter Nawroth, Thomas Fleming
Published 2020-12-01

Quantification of All-Trans Retinoic Acid by Liquid Chromatography–Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes

by Jakob Morgenstern, Thomas Fleming, Elisabeth Kliemank, Maik Brune, Peter Nawroth, Andreas Fischer
Published 2021-01-01

The possible role of methylglyoxal metabolism in cancer

by Khalid O. Alfarouk, Saad S. Alqahtani, Saeed Alshahrani, Jakob Morgenstern, Claudiu T. Supuran, Stephan J. Reshkin
Published 2021-01-01

The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology

by Thomas Schmoch, Florian Uhle, Benedikt H. Siegler, Thomas Fleming, Jakob Morgenstern, Peter P. Nawroth, Markus A. Weigand, Thorsten Brenner
Published 2017-03-01

Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

by Dagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel
Published 2018-12-01

Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans

by Bowen Lou, Mike Boger, Katrin Bennewitz, Carsten Sticht, Stefan Kopf, Jakob Morgenstern, Thomas Fleming, Rüdiger Hell, Zuyi Yuan, Peter Paul Nawroth, Jens Kroll
Published 2020-10-01

Accumulation of acetaldehyde in aldh2.1−/− zebrafish causes increased retinal angiogenesis and impaired glucose metabolism

by David Philipp Wohlfart, Bowen Lou, Chiara Simone Middel, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Rüdiger Hell, Hans-Peter Hammes, Julia Szendrödi, Peter Paul Nawroth, Jens Kroll
Published 2022-04-01

The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136

by Fabiola Garcia Cortizo, Daniel Pfaff, Angela Wirth, Andrea Schlotterer, Rebekka Medert, Jakob Morgenstern, Tobias Weber, Hans-Peter Hammes, Thomas Fleming, Peter Paul Nawroth, Marc Freichel, Aurelio A. Teleman
Published 2022-01-01

Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

by Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos Campos, Aurelio Teleman, Johannes Backs, Peter Nawroth, Thomas Fleming
Published 2020-09-01

Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish

by Xiaogang Li, Felix Schmöhl, Haozhe Qi, Katrin Bennewitz, Christoph T. Tabler, Gernot Poschet, Rüdiger Hell, Nadine Volk, Tanja Poth, Ingrid Hausser, Jakob Morgenstern, Thomas Fleming, Peter Paul Nawroth, Jens Kroll
Published 2020-12-01

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

by Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer, Thorsten Brenner
Published 2019-01-01

Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

by Haozhe Qi, Felix Schmöhl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Rüdiger Hell, Peter Paul Nawroth, Jens Kroll
Published 2021-09-01

Loss of glyoxalase 2 alters the glucose metabolism in zebrafish

by Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, Chiara Simone Middel, Vanessa Erben, Hannes Ott, Tanja Poth, Thomas Fleming, Jakob Morgenstern, Ingrid Hausser, Carsten Sticht, Gernot Poschet, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Published 2023-02-01

Fractional Anisotropy and Troponin T Parallel Structural Nerve Damage at the Upper Extremities in a Group of Patients With Prediabetes and Type 2 Diabetes – A Study Using 3T Magnet...

by Johann M. E. Jende, Zoltan Kender, Jakob Morgenstern, Pascal Renn, Christoph Mooshage, Alexander Juerchott, Stefan Kopf, Stefan Kopf, Peter P. Nawroth, Peter P. Nawroth, Peter P. Nawroth, Martin Bendszus, Felix T. Kurz, Felix T. Kurz
Published 2022-01-01

Impaired Detoxification of Trans, Trans‐2,4‐Decadienal, an Oxidation Product from Omega‐6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease...

by Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
Published 2024-01-01

Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography

by Johann M. E. Jende, Zoltan Kender, Christian Rother, Lucia Alvarez-Ramos, Jan B. Groener, Jan B. Groener, Jan B. Groener, Mirko Pham, Mirko Pham, Jakob Morgenstern, Dimitrios Oikonomou, Artur Hahn, Alexander Juerchott, Jennifer Kollmer, Sabine Heiland, Sabine Heiland, Stefan Kopf, Stefan Kopf, Peter P. Nawroth, Peter P. Nawroth, Peter P. Nawroth, Martin Bendszus, Felix T. Kurz
Published 2020-09-01

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

by Gretchen Wolff, Minako Sakurai, Amit Mhamane, Maria Troullinaki, Adriano Maida, Ioannis K. Deligiannis, Kelvin Yin, Peter Weber, Jakob Morgenstern, Annika Wieder, Yun Kwon, Revathi Sekar, Anja Zeigerer, Michael Roden, Matthias Blüher, Nadine Volk, Tanja Poth, Thilo Hackert, Lena Wiedmann, Francesca De Angelis Rigotti, Juan Rodriguez-Vita, Andreas Fischer, Rajesh Mukthavaram, Pattraranee Limphong, Kiyoshi Tachikawa, Priya Karmali, Joseph Payne, Padmanabh Chivukula, Bilgen Ekim-Üstünel, Celia P. Martinez-Jimenez, Julia Szendrödi, Peter Nawroth, Stephan Herzig
Published 2022-06-01