HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis.

by Ajit Janardhan, Tomek Swigut, Brian Hill, Michael P Myers, Jacek Skowronski
Published 2004-01-01

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

by Oliver I Fregoso, Jinwoo Ahn, Chuanping Wang, Jennifer Mehrens, Jacek Skowronski, Michael Emerman
Published 2013-01-01

Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.

by Smita Srivastava, Selene K Swanson, Nicolas Manel, Laurence Florens, Michael P Washburn, Jacek Skowronski
Published 2008-05-01

HIV-1 Vpr Reprograms CLR4^DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

by Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski
Published 2018-11-01

SIV vpx is essential for macrophage infection but not for development of AIDS.

by Susan V Westmoreland, A Peter Converse, Kasia Hrecka, Mollie Hurley, Heather Knight, Michael Piatak, Jeffrey Lifson, Keith G Mansfield, Jacek Skowronski, Ronald C Desrosiers
Published 2014-01-01

Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A

by In-Ja L. Byeon, Guillermo Calero, Ying Wu, Chang H. Byeon, Jinwon Jung, Maria DeLucia, Xiaohong Zhou, Simon Weiss, Jinwoo Ahn, Caili Hao, Jacek Skowronski, Angela M. Gronenborn
Published 2021-11-01

SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS

by Westmoreland, Susan V., Converse, A. Peter, Hrecka, Kasia, Hurley, Mollie, Knight, Heather, Piatak, Michael, Lifson, Jeffrey, Mansfield, Keith G., Skowronski, Jacek, Desrosiers, Ronald C.
Published 2014