Many ways to break a heart

by Megan Rowton, Ivan P Moskowitz
Published 2015-08-01

Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.

by Eun Young Kim, Li Chen, Yanlin Ma, Wei Yu, Jiang Chang, Ivan P Moskowitz, Jun Wang
Published 2011-01-01

Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.

by Jielin Liu, Henghui Cheng, Menglan Xiang, Lun Zhou, Bingruo Wu, Ivan P Moskowitz, Ke Zhang, Linglin Xie
Published 2019-05-01

Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.

by Xiangying Sun, Zhezhen Wang, Johnathon M Hall, Carlos Perez-Cervantes, Alexander J Ruthenburg, Ivan P Moskowitz, Michael Gribskov, Xinan H Yang
Published 2020-02-01

Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation

by Alan Selewa, Kaixuan Luo, Michael Wasney, Linsin Smith, Xiaotong Sun, Chenwei Tang, Heather Eckart, Ivan P. Moskowitz, Anindita Basu, Xin He, Sebastian Pott
Published 2023-08-01

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

by Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. Moskowitz, Kohta Ikegami
Published 2024-06-01

Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

by Scott A Rankin, Jeffrey D Steimle, Xinan H Yang, Ariel B Rydeen, Kunal Agarwal, Praneet Chaturvedi, Kohta Ikegami, Michael J Herriges, Ivan P Moskowitz, Aaron M Zorn
Published 2021-10-01

A promoter interaction map for cardiovascular disease genetics

by Lindsey E Montefiori, Debora R Sobreira, Noboru J Sakabe, Ivy Aneas, Amelia C Joslin, Grace T Hansen, Grazyna Bozek, Ivan P Moskowitz, Elizabeth M McNally, Marcelo A Nóbrega
Published 2018-07-01

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

by Bhairab N. Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P. Moskowitz, Cyprian V. Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H. van Berlo, Mary G. Garry, Daniel J. Garry
Published 2018-10-01

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.

by Andrew D Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D Bosman, Xiaomeng Ren, Jeffrey D Steimle, Steven A Vokes, Andrew P McMahon, Vladimir V Kalinichenko, Ivan P Moskowitz
Published 2014-10-01

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.

by Andrew D Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D Bosman, Xiaomeng Ren, Linglin Xie, Jeffrey D Steimle, Steven A Vokes, Andrew P McMahon, Vladimir V Kalinichenko, Ivan P Moskowitz
Published 2016-12-01

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

by Jeffrey D. Steimle, Chul Kim, Megan Rowton, Rangarajan D. Nadadur, Zhezhen Wang, Matthew Stocker, Andrew D. Hoffmann, Erika Hanson, Junghun Kweon, Tanvi Sinha, Kyunghee Choi, Brian L. Black, John M. Cunningham, Ivan P. Moskowitz, Kohta Ikegami
Published 2023-06-01

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

by Wenli Dai, Brigitte Laforest, Leonid Tyan, Kaitlyn M Shen, Rangarajan D Nadadur, Francisco J Alvarado, Stefan R Mazurek, Sonja Lazarevic, Margaret Gadek, Yitang Wang, Ye Li, Hector H Valdivia, Le Shen, Michael T Broman, Ivan P Moskowitz, Christopher R Weber
Published 2019-03-01

Chamber-specific transcriptional responses in atrial fibrillation

by Catherine E. Lipovsky, Jesus Jimenez, Qiusha Guo, Gang Li, Tiankai Yin, Stephanie C. Hicks, Somya Bhatnagar, Kentaro Takahashi, David M. Zhang, Brittany D. Brumback, Uri Goldsztejn, Rangarajan D. Nadadur, Carlos Perez-Cervantez, Ivan P. Moskowitz, Shaopeng Liu, Bo Zhang, Stacey L. Rentschler
Published 2020-09-01

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.

by Ferhaan Ahmad, Sanjay K Banerjee, Michele L Lage, Xueyin N Huang, Stephen H Smith, Samir Saba, Jennifer Rager, David A Conner, Andrzej M Janczewski, Kimimasa Tobita, Joseph P Tinney, Ivan P Moskowitz, Antonio R Perez-Atayde, Bradley B Keller, Michael A Mathier, Sanjeev G Shroff, Christine E Seidman, J G Seidman
Published 2008-07-01

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

by Xinan H Yang, Rangarajan D Nadadur, Catharina RE Hilvering, Valerio Bianchi, Michael Werner, Stefan R Mazurek, Margaret Gadek, Kaitlyn M Shen, Joseph Aaron Goldman, Leonid Tyan, Jenna Bekeny, Johnathon M Hall, Nutishia Lee, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Kenneth D Poss, Christopher R Weber, Wouter de Laat, Alexander J Ruthenburg, Ivan P Moskowitz
Published 2017-12-01

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.

by James R Priest, Kazutoyo Osoegawa, Nebil Mohammed, Vivek Nanda, Ramendra Kundu, Kathleen Schultz, Edward J Lammer, Santhosh Girirajan, Todd Scheetz, Daryl Waggott, Francois Haddad, Sushma Reddy, Daniel Bernstein, Trudy Burns, Jeffrey D Steimle, Xinan H Yang, Ivan P Moskowitz, Matthew Hurles, Richard P Lifton, Debbie Nickerson, Michael Bamshad, Evan E Eichler, Seema Mital, Val Sheffield, Thomas Quertermous, Bruce D Gelb, Michael Portman, Euan A Ashley
Published 2016-04-01

Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome

by Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H. Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A. J. Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James E. O’Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Ivan P. Moskowitz, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick
Published 2021-07-01