Amino Acids in Health and Disease: The Good, the Bad, and the Ugly

by Isao Ishii, Madhav Bhatia
Published 2023-03-01

2D DIGE proteomic analysis highlights delayed postnatal repression of α‐fetoprotein expression in homocystinuria model mice

by Shotaro Kamata, Noriyuki Akahoshi, Isao Ishii
Published 2015-01-01

Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography

by Shotaro Kamata, Takuji Oyama, Isao Ishii
Published 2021-03-01

Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease

by Shotaro Kamata, Akihiro Honda, Isao Ishii
Published 2023-08-01

Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells

by Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia
Published 2023-09-01

Sphingosine 1-Phosphate Regulates Obesity and Glucose Homeostasis

by Kazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, Masayuki Fuwa, Hiroyuki Morita
Published 2024-01-01

Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

by Kamila Borowczyk, Jacek Wróblewski, Joanna Suliburska, Noriyuki Akahoshi, Isao Ishii, Hieronim Jakubowski
Published 2018-01-01

Differential adaptive responses to 1‐ or 2‐day fasting in various mouse tissues revealed by quantitative PCR analysis

by Junya Yamamoto, Shotaro Kamata, Asumi Miura, Tomoko Nagata, Ryo Kainuma, Isao Ishii
Published 2015-01-01

Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice

by Noriyuki Akahoshi, Ryoka Hasegawa, Shingo Yamamoto, Rintaro Takemoto, Toshiki Yoshizawa, Waka Kamichatani, Isao Ishii
Published 2023-01-01

2D DIGE proteomic analysis reveals fasting‐induced protein remodeling through organ‐specific transcription factor(s) in mice

by Shotaro Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka, Sayumi Yoshikawa, Noriyuki Akahoshi, Isao Ishii
Published 2018-09-01

Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase—An Animal Model of Cystathioninuria

by Noriyuki Akahoshi, Hiroki Handa, Rintaro Takemoto, Shotaro Kamata, Masahide Yoshida, Tatsushi Onaka, Isao Ishii
Published 2019-07-01

The Gasotransmitter Hydrogen Sulfide (H₂S) Prevents Pathologic Calcification (PC) in Cartilage

by Sonia Nasi, Driss Ehirchiou, Jessica Bertrand, Mariela Castelblanco, James Mitchell, Isao Ishii, Alexander So, Nathalie Busso
Published 2021-09-01

Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis

by Ravinder R Gaddam, Stephen Chambers, Robin Fraser, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Published 2019-06-01

Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease

by Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii
Published 2024-03-01

Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

by Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Published 2017-01-01

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

by Ravinder Reddy Gaddam, Robin Fraser, Alireza Badiei, Stephen Chambers, Victoria C Cogger, David G Le Couteur, Isao Ishii, Madhav Bhatia
Published 2016-01-01

Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disu...

by Noriyuki Akahoshi, Tatsuro Minakawa, Masashi Miyashita, Uran Sugiyama, Chihiro Saito, Rintaro Takemoto, Akihiro Honda, Waka Kamichatani, Shotaro Kamata, Yasumi Anan, Isao Ishii
Published 2020-01-01

Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate

by Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, Isao Ishii
Published 2022-04-01

Hydrogen Sulfide Attenuates Lymphedema Via the Induction of Lymphangiogenesis Through a PI3K/Akt‐Dependent Mechanism

by Junya Suzuki, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Isao Ishii, John W. Calvert, Toyoaki Murohara
Published 2022-11-01

A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice

by Isao Ishii, Shotaro Kamata, Saki Ito, Aya Shimonaga, Maika Koizumi, Maiko Tsushima, Asumi Miura, Tomoko Nagata, Yuka Tosaka, Haruka Ohtani, Waka Kamichatani, Noriyuki Akahoshi
Published 2022-01-01