Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

by Verline Justilien, Roderick P Regala, I-Chu Tseng, Michael P Walsh, Jyotica Batra, Evette S Radisky, Nicole R Murray, Alan P Fields
Published 2012-01-01

Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.

by Chun-Che Tseng, Bailing Jia, Robert Barndt, Yayun Gu, Chien-Yu Chen, I-Chu Tseng, Sheng-Fang Su, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Published 2017-01-01

Matriptase autoactivation is tightly regulated by the cellular chemical environments.

by Jehng-Kang Wang, I-Jou Teng, Ting-Jen Lo, Sean Moore, Yee Hui Yeo, Yun-Chung Teng, Malvika Kaul, Chiann-Chyi Chen, Annie Hong Zuo, Fen-Pai Chou, Xiaoyu Yang, I-Chu Tseng, Michael D Johnson, Chen-Yong Lin
Published 2014-01-01