Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

by Davide Simone, Frank Penkava, Anna Ridley, Stephen Sansom, M. Hussein Al-Mossawi, Paul Bowness
Published 2021-12-01

LBO1 DORIS remission in patients with SLE treated with anifrolumab or placebo during the 4-year TULIP-LTE trial: post hoc analysis

by Richard Furie, Raj Tummala, Kenneth Kalunian, Eric Morand, Gabriel Abreu, Ronald van Vollenhoven, Catharina Lindholm, Hussein Al-Mossawi
Published 2024-03-01

Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor

by Janine Barrett, Seppe Leysen, Cécile Galmiche, Hussein Al-Mossawi, Paul Bowness, Thomas E. Edwards, Alastair D.G. Lawson
Published 2024-12-01

1502 Lupus low disease activity state attainment in the phase 3 placebo-controlled TULIP long-term extension trial of anifrolumab

by Richard A Furie, Eric F Morand, Sule Yavuz, Kenneth C Kalunian, Gabriel Abreu, Ronald van Vollenhoven, Catharina Lindholm, Hussein Al-Mossawi
Published 2024-05-01

Targeting DORIS Remission and LLDAS in SLE: A Review

by Agner R. Parra Sánchez, Ronald F. van Vollenhoven, Eric F. Morand, Ian N. Bruce, Rangi Kandane-Rathnayake, Gudrun Weiss, Raj Tummala, Hussein Al-Mossawi, Alessandro Sorrentino
Published 2023-10-01

Treating to target in psoriatic arthritis: assessing real-world outcomes and optimising therapeutic strategy for adults with psoriatic arthritis—study protocol for the MONITOR-PsA...

by Ines Rombach, William Tillett, Deepak Jadon, Laura Tucker, Marion Watson, Anne Francis, Yvonne Sinomati, Lucy Eldridge, Melina Dritsaki, Susan J. Dutton, Hussein Al-Mossawi, Nicola Gullick, Ben Thompson, Laura C. Coates
Published 2021-03-01

Optimising psoriatic arthritis therapy with immunological methods to increase standard evaluation: the protocol of an open-label multicentre, parallel-group, two-arm randomised con...

by Iain B McInnes, Stefan Siebert, Paul Bowness, Laura C Coates, Anne Francis, Bruce W Kirkham, Alexander Ooms, Hussein Al-Mossawi, Louise Bennett, Nicole Yager, Duncan Richards, Mimi Bogale, Carl Goodyear, Sylvine Lalnunhlimi, Leonie S Taams, Aysin Tulunay Virlan
Published 2023-09-01

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

by Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Published 2019-10-01

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

by Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D. Young, Nicole Yager, Lilian N. Nwosu, Arthur G. Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C. Brown, Andrew L. Croxford, John D. Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M. Hussein Al-Mossawi
Published 2020-09-01

Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohortsResearch in context

by Stephanie J.W. Shoop-Worrall, Saskia Lawson-Tovey, Lucy R. Wedderburn, Kimme L. Hyrich, Nophar Geifman, Aline Kimonyo, Alyssia McNeece, Andrew Dick, Andrew Morris, Annie Yarwood, Athimalaipet Ramanan, Bethany R. Jebson, Chris Wallace, Daniela Dastros-Pitei, Damian Tarasek, Elizabeth Ralph, Emil Carlsson, Emily Robinson, Emma Sumner, Fatema Merali, Fatjon Dekaj, Helen Neale, Hussein Al-Mossawi, Jacqui Roberts, Jenna F. Gritzfeld, Joanna Fairlie, John Bowes, John Ioannou, Kimme L. Hyrich, Lucy R. Wedderburn, Melissa Kartawinata, Melissa Tordoff, Michael Barnes, Michael W. Beresford, Michael Stadler, Nophar Geifman, Paul Martin, Rami Kallala, Sandra Ng, Samantha Smith, Sarah Clarke, Saskia Lawson-Tovey, Soumya Raychaudhuri, Stephanie J.W. Shoop-Worrall, Stephen Eyre, Sumanta Mukherjee, Teresa Duerr, Thierry Sornasse, Vasiliki Alexiou, Victoria J. Burton, Wei-Yu Lin, Wendy Thomson, Zoe Wanstall
Published 2024-02-01

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.

by Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D, Yager, Nicole, Nwosu, Lilian N, Pratt, Arthur G, Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C, Croxford, Andrew L, Isaacs, John D, Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M
Published 2020

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.

by Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D, Yager, Nicole, Nwosu, Lilian N, Pratt, Arthur G, Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C, Croxford, Andrew L, Isaacs, John D, Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M
Published 2020

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

by Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D., Yager, Nicole, Nwosu, Lilian N., Pratt, Arthur G., Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C., Croxford, Andrew L., Isaacs, John D., Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M.
Published 2021

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

by Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D., Yager, Nicole, Nwosu, Lilian N., Pratt, Arthur G., Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C., Croxford, Andrew L., Isaacs, John D., Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M.
Published 2020