Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers

by Robert Lu, Hilda A. Pickett
Published 2022-03-01

A DNA-fiber protocol for single molecule analysis of telomere (SMAT) length and extension events in cancer cells

by Robert Lu, Joshua A.M. Allen, Pablo Galaviz, Hilda A. Pickett
Published 2022-03-01

Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

by Robert Lu, Christopher B. Nelson, Samuel Rogers, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Published 2024-01-01

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

by Anna Kychygina, Marina Dall’Osto, Joshua A. M. Allen, Jean-Charles Cadoret, Vincent Piras, Hilda A. Pickett, Laure Crabbe
Published 2021-06-01

Telomere Length Measurement by Molecular Combing

by Vivian F. S. Kahl, Joshua A. M. Allen, Christopher B. Nelson, Alexander P. Sobinoff, Michael Lee, Tatjana Kilo, Raja S. Vasireddy, Hilda A. Pickett
Published 2020-06-01

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.

by Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett
Published 2015-06-01

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

by Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Published 2019-05-01

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

by Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett
Published 2019-11-01

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres

by Rebecca A. Dagg, Hilda A. Pickett, Axel A. Neumann, Christine E. Napier, Jeremy D. Henson, Erdahl T. Teber, Jonathan W. Arthur, C. Patrick Reynolds, Jayne Murray, Michelle Haber, Alexander P. Sobinoff, Loretta M.S. Lau, Roger R. Reddel
Published 2017-06-01

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

by Hannah S Bender, Elizabeth P Murchison, Hilda A Pickett, Janine E Deakin, Margaret A Strong, Carly Conlan, Daniel A McMillan, Axel A Neumann, Carol W Greider, Gregory J Hannon, Roger R Reddel, Jennifer A Marshall Graves
Published 2012-01-01

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

by Alexandre deNonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli
Published 2022-10-01

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

by Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Published 2024-02-01

A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region

by Jonathan W. Arthur, Hilda A. Pickett, Pasquale M. Barbaro, Tatjana Kilo, Raja S. Vasireddy, Traude H. Beilharz, David R. Powell, Emma L. Hackett, Bruce Bennetts, Julie A. Curtin, Kristi Jones, John Christodoulou, Roger R. Reddel, Juliana Teo, Tracy M. Bryan
Published 2021-05-01

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts

by Laura A. Richards, Ashu Kumari, Kathy Knezevic, Julie AI Thoms, Georg von Jonquieres, Christine E. Napier, Zara Ali, Rosemary O’Brien, Jonathon Marks-Bluth, Michelle F. Maritz, Hilda A Pickett, Jonathan Morris, John E. Pimanda, Karen L. MacKenzie
Published 2020-06-01

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

by Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Published 2024-03-01

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

by Samantha L. Ginn, Anais K. Amaya, Sophia H.Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus V. Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander
Published 2020-02-01

TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis

by Tamera J Corte, Adam Jaffe, Christopher Grainge, Jeremy Wrobel, Hiran Selvadurai, Daniel C Chambers, Maxine Tan, Ian Glaspole, Peter Hopkins, Paul N Reynolds, Hilda A Pickett, Nicole S Goh, John A Mackintosh, Maria Pietsch, Viviana Lutzky, Debra Enever, Sandra Bancroft, Simon H Apte, Joanne L Dickinson
Published 2021-12-01

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

by Mark Pinese, Paul Lacaze, Emma M. Rath, Andrew Stone, Marie-Jo Brion, Adam Ameur, Sini Nagpal, Clare Puttick, Shane Husson, Dmitry Degrave, Tina Navin Cristina, Vivian F. S. Kahl, Aaron L. Statham, Robyn L. Woods, John J. McNeil, Moeen Riaz, Margo Barr, Mark R. Nelson, Christopher M. Reid, Anne M. Murray, Raj C. Shah, Rory Wolfe, Joshua R. Atkins, Chantel Fitzsimmons, Heath M. Cairns, Melissa J. Green, Vaughan J. Carr, Mark J. Cowley, Hilda A. Pickett, Paul A. James, Joseph E. Powell, Warren Kaplan, Greg Gibson, Ulf Gyllensten, Murray J. Cairns, Martin McNamara, Marcel E. Dinger, David M. Thomas
Published 2020-01-01

The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study

by Aimee L. Davidson, Uwe Dressel, Sarah Norris, Daffodil M. Canson, Dylan M. Glubb, Cristina Fortuno, Georgina E. Hollway, Michael T. Parsons, Miranda E. Vidgen, Oliver Holmes, Lambros T. Koufariotis, Vanessa Lakis, Conrad Leonard, Scott Wood, Qinying Xu, Amy E. McCart Reed, Hilda A. Pickett, Mohammad K. Al-Shinnag, Rachel L. Austin, Jo Burke, Elisa J. Cops, Cassandra B. Nichols, Annabel Goodwin, Marion T. Harris, Megan J. Higgins, Emilia L. Ip, Catherine Kiraly-Borri, Chiyan Lau, Julia L. Mansour, Michael W. Millward, Melissa J. Monnik, Nicholas S. Pachter, Abiramy Ragunathan, Rachel D. Susman, Sharron L. Townshend, Alison H. Trainer, Simon L. Troth, Katherine M. Tucker, Mathew J. Wallis, Maie Walsh, Rachel A. Williams, Ingrid M. Winship, Felicity Newell, Emma Tudini, John V. Pearson, Nicola K. Poplawski, Helen G. Mar Fan, Paul A. James, Amanda B. Spurdle, Nicola Waddell, Robyn L. Ward
Published 2023-09-01

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.

by Jonathan Beesley, Hilda A Pickett, Sharon E Johnatty, Alison M Dunning, Xiaoqing Chen, Jun Li, Kyriaki Michailidou, Yi Lu, David N Rider, Rachel T Palmieri, Michael D Stutz, Diether Lambrechts, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Jenny Chang-Claude, Stefan Nickels, Alina Vrieling, Dieter Flesch-Janys, Shan Wang-Gohrke, Ursula Eilber, Natalia Bogdanova, Natalia Antonenkova, Ingo B Runnebaum, Thilo Dörk, Marc T Goodman, Galina Lurie, Lynne R Wilkens, Rayna K Matsuno, Lambertus A Kiemeney, Katja K H Aben, Tamara Marees, Leon F A G Massuger, Brooke L Fridley, Robert A Vierkant, Elisa V Bandera, Sara H Olson, Irene Orlow, Lorna Rodriguez-Rodriguez, Linda S Cook, Nhu D Le, Angela Brooks-Wilson, Linda E Kelemen, Ian Campbell, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Usha Menon, Shahana Ahmed, Caroline Baynes, Paul D Pharoah, kConFab Investigators, Australian Ovarian Cancer Study Group, ABCTB Investigators, Kenneth Muir, Artitaya Lophatananon, Arkom Chaiwerawattana, Surapon Wiangnon, Stuart Macgregor, Douglas F Easton, Roger R Reddel, Ellen L Goode, Georgia Chenevix-Trench, Ovarian Cancer Association Consortium
Published 2011-01-01