Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.

by Brouns, Sanne LN, van Geffen, Johanna P, Campello, Elena, Swieringa, Frauke, Spiezia, Luca, van Oerle, René, Provenzale, Isabella, Verdoold, Remco, Farndale, Richard W, Clemetson, Kenneth J, Spronk, Henri MH, van der Meijden, Paola EJ, Cavill, Rachel, Kuijpers, Marijke JE, Castoldi, Elisabetta, Simioni, Paolo, Heemskerk, Johan WM
Published 2020

Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time.

by Heubel-Moenen, Floor CJI, Brouns, Sanne LN, Herfs, Linda, Boerenkamp, Lara S, Jooss, Natalie J, Wetzels, Rick JH, Verhezen, Paul WM, Machiels, Patric, Megy, Karyn, Downes, Kate, Heemskerk, Johan WM, Beckers, Erik AM, Henskens, Yvonne MC
Published 2022

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.

by van Geffen, Johanna P, Swieringa, Frauke, van Kuijk, Kim, Tullemans, Bibian ME, Solari, Fiorella A, Peng, Bing, Clemetson, Kenneth J, Farndale, Richard W, Dubois, Ludwig J, Sickmann, Albert, Zahedi, René P, Ahrends, Robert, Biessen, Erik AL, Sluimer, Judith C, Heemskerk, Johan WM, Kuijpers, Marijke JE
Published 2021

Identification of platelet function defects by multi-parameter assessment of thrombus formation.

by de Witt, Susanne M, Swieringa, Frauke, Cavill, Rachel, Lamers, Moniek ME, van Kruchten, Roger, Mastenbroek, Tom, Baaten, Constance, Coort, Susan, Pugh, Nicholas, Schulz, Ansgar, Scharrer, Inge, Jurk, Kerstin, Zieger, Barbara, Clemetson, Kenneth J, Farndale, Richard W, Heemskerk, Johan WM, Cosemans, Judith MEM
Published 2014

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

by Mori, Jun, Nagy, Zoltan, Di Nunzio, Giada, Smith, Christopher W, Geer, Mitchell J, Al Ghaithi, Rashid, van Geffen, Johanna P, Heising, Silke, Boothman, Luke, Tullemans, Bibian ME, Correia, Joao N, Tee, Louise, Kuijpers, Marijke JE, Harrison, Paul, Heemskerk, Johan WM, Jarvis, Gavin E, Tarakhovsky, Alexander, Weiss, Arthur, Mazharian, Alexandra, Senis, Yotis A
Published 2018

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces.

by Jooss, Natalie J, De Simone, Ilaria, Provenzale, Isabella, Fernández, Delia I, Brouns, Sanne LN, Farndale, Richard W, Henskens, Yvonne MC, Kuijpers, Marijke JE, Ten Cate, Hugo, van der Meijden, Paola EJ, Cavill, Rachel, Heemskerk, Johan WM
Published 2019

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.

by Hall, Kellie J, Harper, Matthew T, Gilio, Karen, Cosemans, Judith M, Heemskerk, Johan WM, Poole, Alastair W
Published 2020

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.

by Baaten, Constance CFMJ, Meacham, Stuart, de Witt, Susanne M, Feijge, Marion AH, Adams, David J, Akkerman, Jan-Willem N, Cosemans, Judith MEM, Grassi, Luigi, Jupe, Steve, Kostadima, Myrto, Mattheij, Nadine JA, Prins, Martin H, Ramirez-Solis, Ramiro, Soehnlein, Oliver, Swieringa, Frauke, Weber, Christian, White, Jacqueline K, Ouwehand, Willem H, Heemskerk, Johan WM
Published 2018

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions.

by Huang, Jingnan, Swieringa, Frauke, Solari, Fiorella A, Provenzale, Isabella, Grassi, Luigi, De Simone, Ilaria, Baaten, Constance CFMJ, Cavill, Rachel, Sickmann, Albert, Frontini, Mattia, Heemskerk, Johan WM
Published 2021

High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

by van Geffen, Johanna P, Brouns, Sanne LN, Batista, Joana, McKinney, Harriet, Kempster, Carly, Nagy, Magdolna, Sivapalaratnam, Suthesh, Baaten, Constance CFMJ, Bourry, Nikki, Frontini, Mattia, Jurk, Kerstin, Krause, Manuela, Pillitteri, Daniele, Swieringa, Frauke, Verdoold, Remco, Cavill, Rachel, Kuijpers, Marijke JE, Ouwehand, Willem H, Downes, Kate, Heemskerk, Johan WM
Published 2019

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

by Hofmann, Inga, Geer, Mitchell J, Vögtle, Timo, Crispin, Andrew, Campagna, Dean R, Barr, Alastair, Calicchio, Monica L, Heising, Silke, van Geffen, Johanna P, Kuijpers, Marijke JE, Heemskerk, Johan WM, Eble, Johannes A, Schmitz-Abe, Klaus, Obeng, Esther A, Douglas, Michael, Freson, Kathleen, Pondarré, Corinne, Favier, Rémi, Jarvis, Gavin E, Markianos, Kyriacos, Turro, Ernest, Ouwehand, Willem H, Mazharian, Alexandra, Fleming, Mark D, Senis, Yotis A
Published 2018

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

by Geer, Mitchell J, van Geffen, Johanna P, Gopalasingam, Piraveen, Vögtle, Timo, Smith, Christopher W, Heising, Silke, Kuijpers, Marijke JE, Tullemans, Bibian ME, Jarvis, Gavin E, Eble, Johannes A, Jeeves, Mark, Overduin, Michael, Heemskerk, Johan WM, Mazharian, Alexandra, Senis, Yotis A
Published 2018

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

by Simeoni, Ilenia, Stephens, Jonathan C, Hu, Fengyuan, Deevi, Sri VV, Megy, Karyn, Bariana, Tadbir K, Lentaigne, Claire, Schulman, Sol, Sivapalaratnam, Suthesh, Vries, Minka JA, Westbury, Sarah K, Greene, Daniel, Papadia, Sofia, Alessi, Marie-Christine, Attwood, Antony P, Ballmaier, Matthias, Baynam, Gareth, Bermejo, Emilse, Bertoli, Marta, Bray, Paul F, Bury, Loredana, Cattaneo, Marco, Collins, Peter, Daugherty, Louise C, Favier, Rémi, French, Deborah L, Furie, Bruce, Gattens, Michael, Germeshausen, Manuela, Ghevaert, Cedric, Goodeve, Anne C, Guerrero, Jose A, Hampshire, Daniel J, Hart, Daniel P, Heemskerk, Johan WM, Henskens, Yvonne MC, Hill, Marian, Hogg, Nancy, Jolley, Jennifer D, Kahr, Walter H, Kelly, Anne M, Kerr, Ron, Kostadima, Myrto, Kunishima, Shinji, Lambert, Michele P, Liesner, Ri, López, José A, Mapeta, Rutendo P, Mathias, Mary, Millar, Carolyn M, Nathwani, Amit, Neerman-Arbez, Marguerite, Nurden, Alan T, Nurden, Paquita, Othman, Maha, Peerlinck, Kathelijne, Perry, David J, Poudel, Pawan, Reitsma, Pieter, Rondina, Matthew T, Smethurst, Peter A, Stevenson, William, Szkotak, Artur, Tuna, Salih, van Geet, Christel, Whitehorn, Deborah, Wilcox, David A, Zhang, Bin, Revel-Vilk, Shoshana, Gresele, Paolo, Bellissimo, Daniel B, Penkett, Christopher J, Laffan, Michael A, Mumford, Andrew D, Rendon, Augusto, Gomez, Keith, Freson, Kathleen, Ouwehand, Willem H, Turro, Ernest
Published 2016

Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

by Hadinnapola, Charaka, Bleda, Marta, Haimel, Matthias, Screaton, Nicholas, Swift, Andrew, Dorfmüller, Peter, Preston, Stephen D, Southwood, Mark, Hernandez-Sanchez, Jules, Martin, Jennifer, Treacy, Carmen, Yates, Katherine, Bogaard, Harm, Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A, Gibbs, Simon, Girerd, Barbara, Holden, Simon, Humbert, Marc, Kiely, David G, Lawrie, Allan, Machado, Rajiv, MacKenzie Ross, Robert, Moledina, Shahin, Montani, David, Newnham, Michael, Peacock, Andrew, Pepke-Zaba, Joanna, Rayner-Matthews, Paula, Shamardina, Olga, Soubrier, Florent, Southgate, Laura, Suntharalingam, Jay, Toshner, Mark, Trembath, Richard, Noordegraaf, Anton Vonk, Wilkins, Martin R, Wort, Stephen J, Wharton, John, Gräf, Stefan, Morrell, Nicholas W, Aitman, Timothy, Bennett, David, Caulfield, Mark, Chinnery, Patrick, Gale, Daniel, Koziell, Ania, Kuijpers, Taco W, Laffan, Michael A, Maher, Eamonn, Markus, Hugh S, Ouwehand, Willem H, Perry, David, Raymond, F Lucy, Roberts, Irene, Smith, Kenneth, Thrasher, Adrian, Watkins, Hugh, Williamson, Catherine, Woods, Geoffrey, Ashford, Sofie, Bradley, John R, Fletcher, Debra, Hammerton, Tracey, James, Roger, Kingston, Nathalie, Ouwehand, Willem H, Penkett, Christopher J, Raymond, F Lucy, Stirrups, Kathleen, Veltman, Marijke, Young, Tim, Ashford, Sofie, Brown, Matthew, Clements-Brod, Naomi, Davis, John, Dewhurst, Eleanor, Erwood, Marie, Frary, Amy, Linger, Rachel, Papadia, Sofia, Rehnstrom, Karola, Stark, Hannah, Allsup, David, Austin, Steve, Bakchoul, Tamam, Bariana, Tadbir K, Bolton-Maggs, Paula, Chalmers, Elizabeth, Collins, Peter, Erber, Wendy N, Everington, Tamara, Favier, Remi, Freson, Kathleen, Furie, Bruce, Gattens, Michael, Gomez, Keith, Greene, Daniel, Greinacher, Andreas, Hart, Daniel, Heemskerk, Johan WM, Henskens, Yvonne, Kazmi, Rashid, Keeling, David, Kelly, Anne M, Laffan, Michael A, Lambert, Michele P, Lentaigne, Claire, Liesner, Ri, Mangles, Sarah, Mathias, Mary, Millar, Carolyn M, Mumford, Andrew, Nurden, Paquita, Ouwehand, Willem H, Papadia, Sofia, Payne, Jeanette, Pasi, John, Perry, David J, Peerlinck, Kathelijne, Richards, Michael, Rondina, Matthew, Roughley, Catherine, Schulman, Sol, Schulze, Harald, Scully, Marie, Sivapalaratnam, Suthesh, Tait, R Campbell, Talks, Kate, Thachil, Jecko, Turro, Ernest, Toh, Cheng-Hock, Van Geet, Chris, De Vries, Minka, Warner, Timothy Q, Westbury, Sarah, Furnell, Abigail, Mapeta, Rutendo, Simeoni, Ilenia, Staines, Simon, Stephens, Jonathan, Stirrups, Kathleen, Whitehorn, Deborah, Watt, Christopher, Attwood, Antony, Daugherty, Louise, Deevi, Sri VV, Halmagyi, Csaba, Hu, Fengyuan, James, Roger, Matser, Vera, Meacham, Stuart, Megy, Karyn, Penkett, Christopher J, Stirrups, Kathleen, Titterton, Catherine, Tuna, Salih, Yu, Ping, von Ziegenweldt, Julie, Astle, William, Carss, Keren, Greene, Daniel, Lango-Allen, Hana, Turro, Ernest, Astle, William, Greene, Daniel, Richardson, Sylvia, Turro, Ernest, Calleja, Paul, Rankin, Stuart, Turek, Wojciech, Bryson, Christine, Anderson, Julie, Fletcher, Debra, McJannet, Coleen, Stock, Sophie, Young, Tim, Wassmer, Evangeline, Sohal, Aman, Santra, Saikat, Vogt, Julie, Chitre, Manali, Krishnakumar, Deepa, Ambegaonkar, Gautum, Maw, Anna, Armstrong, Ruth, Park, Soo-Mi, Mehta, Sarju, Paterson, Joan, Carmichael, Jenny, Allen, Louise, Hensiek, Anke, Firth, Helen, Stein, Penelope, Deegan, Patrick, Doffinger, Rainer, Parker, Alasdair, Bitner-Glindzicz, Maria, Scott, Richard, Hurst, Jane, Rosser, Elisabeth, Lees, Melissa, Clement, Emma, Henderson, Robert, Thompson, Dorothy, Gardham, Alice, Gissen, Paul, Josifova, Dragana, Thomas, Ellen, Patch, Chris, Deshpande, Charu, Flinter, Frances, Holder, Muriel, Canham, Natalie, Wakeling, Emma, Holder, Susan, Ghali, Neeti, Brady, Angie, Clowes, Virginia, MacLaren, Robert, Webster, Andrew, Moore, Anthony, Arno, Gavin, Michaelides, Michel, Rankin, Julia, Kurian, Manju, Murphy, Elaine, Carss, Keren, Sanchis-Juan, Alba, Erwood, Marie, Dewhurst, Eleanor, Grozeva, Detelina, Raymond, F Lucy, Reid, Evan, Woods, Geoff, Tischkowitz, Marc, Sandford, Richard, Ali, Sonia, Creaser-Myers, Amanda, Cookson, Victoria, DaCosta, Rosa, Dormand, Natalie, Ghataorhe, Pavandeep K, Greenhalgh, Alan, Huis in’t Veld, Anna, Kennedy, Fiona, Mackenzie Ross, Rob, Masati, Larahmie, Meehan, Sharon, Othman, Shokri, Pollock, Val, Polwarth, Gary, Rhodes, Christopher J, Rue-Albrecht, Kevin, Schotte, Gwen, Shipley, Debbie, Tan, Yvonne, Wanjiku, Ivy, Wort, John, Smith, Kenneth, Kuijpers, Taco, Thrasher, Adrian, Thaventhiran, James, Brown, Matthew, Lango Allen, Hana, Simeoni, Ilenia, Staples, Emily, Samarghitean, Crina, Alachkar, Hana, Antrobus, Richard, Arumugakani, Gururaj, Bacchelli, Chiara, Baxendale, Helen, Bethune, Claire, Bibi, Shahnaz, Booth, Claire, Browning, Michael, Burns, Siobhan, Chandra, Anita, Cooper, Nichola, Davies, Sophie, Devlin, Lisa, Doffinger, Rainer, Drewe, Elizabeth, Edgar, David, Egner, William, Ghurye, Rohit, Gilmour, Kimberley, Goddard, Sarah, Gordins, Pavel, Grigoriadou, Sofia, Hackett, Scott, Hague, Rosie, Hayman, Grant, Herwadkar, Archana, Huissoon, Aarnoud, Jolles, Stephen, Kelleher, Peter, Kumararatne, Dinakantha, Lear, Sara, Longhurst, Hilary, Lorenzo, Lorena, Maimaris, Jesmeen, Manson, Ania, McDermott, Elizabeth, Murng, Sai, Nejentsev, Sergey, Noorani, Sadia, Oksenhendler, Eric, Ponsford, Mark, Qasim, Waseem, Quinti, Isabella, Richter, Alex, Sargur, Ravishankar, Savic, Sinisa, Seneviratne, Suranjith, Sewell, Carrock, Stauss, Hans, Thomas, Moira, Welch, Steve, Willcocks, Lisa, Yeatman, Nigel, Yong, Patrick
Published 2018