Pharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells

by Safiya Naina Marikar, Keith Al-Hasani, Ishant Khurana, Harikrishnan Kaipananickal, Jun Okabe, Scott Maxwell, Assam El-Osta
Published 2023-06-01

DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure

by Chris R. Bain, Mark Ziemann, Antony Kaspi, Abdul Waheed Khan, Rachael Taylor, Hugh Trahair, Ishant Khurana, Harikrishnan Kaipananickal, Sophie Wallace, Assam El‐Osta, Paul S. Myles, Kiymet Bozaoglu
Published 2020-10-01

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

by Keith Al-Hasani, Safiya Naina Marikar, Harikrishnan Kaipananickal, Scott Maxwell, Jun Okabe, Ishant Khurana, Thomas Karagiannis, Julia J. Liang, Lina Mariana, Thomas Loudovaris, Thomas Kay, Assam El-Osta
Published 2024-01-01

Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes

by Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sørine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jørgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O.Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C.W. Ma, Juliana C.N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Published 2023-02-01

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

by Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthuis, Werner J.H. Koopman, Musa Mhlanga, Assam El-Osta, Leo A.B. Joosten, Mihai G. Netea, Niels P. Riksen
Published 2020-04-01