Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells

by Anouk Zaal, R. J. Eveline Li, Joyce Lübbers, Sven C. M. Bruijns, Hakan Kalay, Yvette van Kooyk, Sandra J. van Vliet
Published 2020-02-01

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

by Sophie K. Horrevorts, Sanne Duinkerken, Karien Bloem, Karien Bloem, Pablo Secades, Hakan Kalay, René J. Musters, Sandra J. van Vliet, Juan J. García-Vallejo, Yvette van Kooyk
Published 2018-06-01

Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma

by Dieke van Dinther, Henrike Veninga, Mirjam Revet, Leoni Hoogterp, Katarzyna Olesek, Joanna Grabowska, Ellen G. F. Borg, Hakan Kalay, Yvette van Kooyk, Joke M. M. den Haan
Published 2018-09-01

849 Optimization of a GM3-containing liposomal vaccine that delivers antigen to CD169+ splenic macrophages

by Gert Storm, Maarten Nijen Twilhaar, Lucas Czentner Colomo, Joanna Grabowska, Alsya Affandi, Katarina Olesek, Hakan Kalay, Rene van Nostrum, Paul Crocker, Yvette van Kooyk, Joke den Haan
Published 2020-11-01

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

by Sophie A. Dusoswa, Sophie K. Horrevorts, Martino Ambrosini, Hakan Kalay, Nanne J. Paauw, Rienk Nieuwland, Michiel D. Pegtel, Tom Würdinger, Yvette Van Kooyk, Juan J. Garcia-Vallejo
Published 2019-12-01

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

by Sjoerd T. T. Schetters, Laura J. W. Kruijssen, Matheus H. W. Crommentuijn, Hakan Kalay, Jordi Ochando, Jordi Ochando, Joke M. M. den Haan, Juan J. Garcia-Vallejo, Yvette van Kooyk
Published 2018-05-01

Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells.

by Cynthia M Fehres, Sven C M Bruijns, Brigit N Sotthewes, Hakan Kalay, Lana Schaffer, Steven R Head, Tanja D de Gruijl, Juan J Garcia-Vallejo, Yvette van Kooyk
Published 2015-01-01

Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans

by Dieke van Dinther, Miguel Lopez Venegas, Henrike Veninga, Katarzyna Olesek, Leoni Hoogterp, Mirjam Revet, Martino Ambrosini, Hakan Kalay, Johannes Stöckl, Yvette van Kooyk, Joke M. M. den Haan
Published 2019-02-01

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses

by Lis Noelia Velasquez, Philipp Stüve, Maria Virginia Gentilini, Maxine Swallow, Judith Bartel, Nils Yngve Lycke, Daniel Barkan, Mariana Martina, Hugo D. Lujan, Hakan Kalay, Yvette van Kooyk, Tim D. Sparwasser, Luciana Berod
Published 2018-03-01

Optimization of Liposomes for Antigen Targeting to Splenic CD169⁺ Macrophages

by Maarten K. Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J. Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M.M. den Haan
Published 2020-11-01

Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells

by Aram M. de Haas, Dorian A. Stolk, Sjoerd T. T. Schetters, Laura Goossens-Kruijssen, Eelco Keuning, Martino Ambrosini, Louis Boon, Hakan Kalay, Gert Storm, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Published 2024-04-01

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

by Ingeborg Streng-Ouwehand, Nataschja I Ho, Manja Litjens, Hakan Kalay, Martine Annemarie Boks, Lenneke AM Cornelissen, Satwinder Kaur Singh, Eirikur Saeland, Juan J Garcia-Vallejo, Ferry A Ossendorp, Wendy WJ Unger, Yvette van Kooyk
Published 2016-03-01

Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation

by Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk
Published 2019-06-01

Quantitative Phosphoproteomic Analysis Reveals Dendritic Cell- Specific STAT Signaling After α2-3–Linked Sialic Acid Ligand Binding

by Rui-Jún Eveline Li, Aram de Haas, Ernesto Rodríguez, Hakan Kalay, Anouk Zaal, Connie R. Jimenez, Sander R. Piersma, Thang V. Pham, Alex A. Henneman, Richard R. de Goeij-de Haas, Sandra J. van Vliet, Yvette van Kooyk
Published 2021-04-01

Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition

by Dorian A. Stolk, Sophie K. Horrevorts, Sjoerd T.T. Schetters, Laura J.W. Kruijssen, Sanne Duinkerken, Eelco Keuning, Martino Ambrosini, Hakan Kalay, Rieneke van de Ven, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Published 2021-06-01

Incorporation of Toll-Like Receptor Ligands and Inflammasome Stimuli in GM3 Liposomes to Induce Dendritic Cell Maturation and T Cell Responses

by Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Gert Storm, Gert Storm, Joke M. M. den Haan
Published 2022-02-01

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

by Dorian A. Stolk, Aram de Haas, Jana Vree, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Published 2020-05-01

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

by Dieke van Dinther, Henrike Veninga, Salvador Iborra, Ellen G.F. Borg, Leoni Hoogterp, Katarzyna Olesek, Marieke R. Beijer, Sjoerd T.T. Schetters, Hakan Kalay, Juan J. Garcia-Vallejo, Kees L. Franken, Lamin B. Cham, Karl S. Lang, Yvette van Kooyk, David Sancho, Paul R. Crocker, Joke M.M. den Haan
Published 2018-02-01

Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs

by Brigitte-Carole Keumatio Doungtsop, MSc, Eleonora Nardini, MSc, Hakan Kalay, BSc, Serge A. Versteeg, MSc, Joyce Lübbers, PhD, Gaby van Barneveld, MSc, Eveline R.J. Li, PhD, Sandra J. van Vliet, PhD, Ronald van Ree, PhD, Esther C. de Jong, PhD, Yvette van Kooyk, PhD
Published 2024-02-01

CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

by Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Anno Saris, Eline S. Zwart, Eline S. Zwart, Esther J. Nossent, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Gert Storm, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Published 2021-07-01