Selective pharmacologic targeting of CTPS1 shows single-agent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma

by Romane Durand, Céline Bellanger, Charlotte Kervoëlen, Benoit Tessoulin, Christelle Dousset, Emmanuelle Menoret, Hélène Asnagli, Andrew Parker, Philip Beer, Catherine Pellat-Deceunynck, David Chiron
Published 2024-02-01

CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma

by Hélène Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E. Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A. Beer
Published 2023-04-01

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

by Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour
Published 2024-03-01