Multipurpose Prevention Technologies: Biomedical Tools to Prevent HIV-1, HSV-2, and Unintended Pregnancies

by Andrea Ries Thurman, Meredith R. Clark, Gustavo F. Doncel
Published 2011-01-01

Preclinical and Early Clinical Development of Tenofovir Alafenamide/Elvitegravir Topical Inserts for Effective On-Demand Vaginal and Rectal HIV Prevention

by M. Melissa Peet, Vivek Agrahari, Meredith R. Clark, Gustavo F. Doncel
Published 2024-03-01

Preferred product attributes of a multipurpose vaginal ring: Findings from a phase 1 trial

by Elizabeth E. Tolley, Homaira Hanif, Andrea Thurman, Vivian Brache, Gustavo F. Doncel
Published 2023-03-01

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

by Raina N. Fichorova, Hidemi S. Yamamoto, Mary L. Delaney, Andrew B. Onderdonk, Gustavo F. Doncel
Published 2011-12-01

Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung Cells

by Maimoona S. Bhutta, Daniel G. Sausen, Elisa S. Gallo, Harel Dahari, Gustavo F. Doncel, Ronen Borenstein
Published 2021-09-01

Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention

by Meredith R. Clark, M. Melissa Peet, Sarah Davis, Gustavo F. Doncel, David R. Friend
Published 2014-12-01

Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant tech...

by Oluwatosin E Adedipe, Terry A Jacot, Andrea R Thurman, Gustavo F Doncel, Meredith R Clark
Published 2018-01-01

Potential biomarkers to predict return to fertility after discontinuation of female contraceptives—looking to the future

by Amanda Cordova-Gomez, Andrew P. Wong, Lee B. Sims, Gustavo F. Doncel, Laneta J. Dorflinger
Published 2023-08-01

Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice

by Maimoona S. Bhutta, Oren Shechter, Elisa S. Gallo, Stephen D. Martin, Esther Jones, Gustavo F. Doncel, Ronen Borenstein
Published 2021-01-01

Development of a composite measure of product adherence, protocol compliance, and semen exposure using DNA and protein biomarkers for topical HIV prevention studies.

by Terry A Jacot, Ashley Nelson, Andrea Thurman, Angela D M Kashuba, David F Archer, Gustavo F Doncel
Published 2014-01-01

Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical Tissues.

by Christiane Rollenhagen, Sherrill L Macura, Melissa J Lathrop, Todd A Mackenzie, Gustavo F Doncel, Susana N Asin
Published 2015-01-01

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV

by Ashana Puri, Sonalika A. Bhattaccharjee, Wei Zhang, Meredith Clark, Onkar N. Singh, Gustavo F. Doncel, Ajay K. Banga
Published 2019-04-01

Synthesis and Biological Evaluation of 5′-<i>O</i>-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides

by Hitesh K. Agarwal, Bhupender S. Chhikara, Guofeng Ye, Sitaram Bhavaraju, Ajay Dixit, Anil Kumar, Gustavo F. Doncel, Keykavous Parang
Published 2022-05-01

End-user research in support of long-acting systemic antiretroviral delivery systems: insights from qualitative research with providers and target users in South Africa

by Morgan S. Brown, Homaira Hanif, Kristen M. Little, Meredith R. Clark, Andrea R. Thurman, Lola Flomen, Gustavo F. Doncel
Published 2022-12-01

Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety.

by Theodore J Segarra, Esra Fakioglu, Natalia Cheshenko, Sarah S Wilson, Pedro M M Mesquita, Gustavo F Doncel, Betsy C Herold
Published 2011-01-01

Formulation Development for Transdermal Delivery of Raloxifene, a Chemoprophylactic Agent against Breast Cancer

by Deepal Vora, Amruta Dandekar, Sonalika Bhattaccharjee, Onkar N. Singh, Vivek Agrahari, M. Melissa Peet, Gustavo F. Doncel, Ajay K. Banga
Published 2022-03-01

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings.

by Andrea Ries Thurman, Jill L Schwartz, Jacques Ravel, Pawel Gajer, Mark A Marzinke, Nazita Yousefieh, Sharon M Anderson, Gustavo F Doncel
Published 2019-01-01

Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir

by Aaminat Qureshi, Louise A. Ouattara, Naglaa Salem El-Sayed, Amita Verma, Gustavo F. Doncel, Muhammad Iqbal Choudhary, Hina Siddiqui, Keykavous Parang
Published 2022-07-01

The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception

by Raina N. Fichorova, Pai-Lien Chen, Charles S. Morrison, Gustavo F. Doncel, Kevin Mendonca, Cynthia Kwok, Tsungai Chipato, Robert Salata, Christine Mauck
Published 2015-10-01

Development and Preclinical Investigation of Physically Cross-Linked and pH-Sensitive Polymeric Gels as Potential Vaginal Contraceptives

by Ankit Rochani, Vivek Agrahari, Neelima Chandra, Onkar N. Singh, Timothy J. McCormick, Gustavo F. Doncel, Meredith R. Clark, Gagan Kaushal
Published 2022-04-01