SARS‐CoV‐2 Omicron variant: Characteristics and prevention

by Xuemei He, Weiqi Hong, Xiangyu Pan, Guangwen Lu, Xiawei Wei
Published 2021-12-01

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

by Liyan Guo, Sheng Lin, Zimin Chen, Yu Cao, Bin He, Guangwen Lu
Published 2023-05-01

In vitro Transcriptome Analysis of Two Chinese Isolates of Streptococcus suis Serotype 2

by Dake Zhang, Nan Du, Sufang Ma, Qingtao Hu, Guangwen Lu, Wei Chen, Changqing Zeng
Published 2014-12-01

Crystal structure of Usutu virus envelope protein in the pre-fusion state

by Zimin Chen, Fei Ye, Sheng Lin, Fanli Yang, Yanwei Cheng, Yu Cao, Zhujun Chen, Guangwen Lu
Published 2018-11-01

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D.

by An Li, Guangwen Lu, Jianxun Qi, Lili Wu, Kegong Tian, Tingrong Luo, Yi Shi, Jinghua Yan, George F Gao
Published 2017-05-01

Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding domain as an antigen.

by Jiaming Lan, Yao Deng, Hong Chen, Guangwen Lu, Wen Wang, Xiaojuan Guo, Zhuozhuang Lu, George F Gao, Wenjie Tan
Published 2014-01-01

Crystal structure of vaccinia virus G3/L5 sub-complex reveals a novel fold with extended inter-molecule interactions conserved among orthopoxviruses

by Sheng Lin, Dan Yue, Fanli Yang, Zimin Chen, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Guangwen Lu
Published 2023-12-01

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy A...

by Sheng Lin, Zimin Chen, Xindan Zhang, Ao Wen, Xin Yuan, Chongzhang Yu, Jing Yang, Bin He, Yu Cao, Guangwen Lu
Published 2022-02-01

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

by Fei Ye, Fanli Yang, Ruijie Yu, Xi Lin, Jianxun Qi, Zhujun Chen, Yu Cao, Yuquan Wei, George F. Gao, Guangwen Lu
Published 2018-03-01

Structural basis of poxvirus A16/G9 binding for sub-complex formation

by Fanli Yang, Sheng Lin, Zimin Chen, Dan Yue, Ming Yang, Bin He, Yu Cao, Haohao Dong, Jian Li, Qi Zhao, Guangwen Lu
Published 2023-12-01

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

by Hong Lei, Aqu Alu, Jingyun Yang, Cai He, Weiqi Hong, Zesheng Cheng, Li Yang, Jiong Li, Zhenling Wang, Wei Wang, Guangwen Lu, Xiawei Wei
Published 2020-12-01

A recombinant spike‐XBB.1.5 protein vaccine induces broad‐spectrum immune responses against XBB.1.5‐included Omicron variants of SARS‐CoV‐2

by Cai He, Aqu Alu, Hong Lei, Jingyun Yang, Weiqi Hong, Xiangrong Song, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Guangwen Lu, Xiawei Wei
Published 2023-06-01

Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant have a reduced ability to induce the immune response

by Cai He, Xuemei He, Jingyun Yang, Hong Lei, Weiqi Hong, Xiangrong Song, Li Yang, Jiong Li, Wei Wang, Guobo Shen, Guangwen Lu, Xiawei Wei
Published 2022-04-01

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

by Yuan Yuan, Duanfang Cao, Yanfang Zhang, Jun Ma, Jianxun Qi, Qihui Wang, Guangwen Lu, Ying Wu, Jinghua Yan, Yi Shi, Xinzheng Zhang, George F. Gao
Published 2017-04-01

Corrigendum to “Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge” [...

by Jiaming Lan, Yanfeng Yao, Yao Deng, Hong Chen, Guangwen Lu, Wen Wang, Linlin Bao, Wei Deng, Qiang Wei, George F. Gao, Chuan Qin, Wenjie Tan
Published 2021-10-01

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

by Jiaming Lan, Yanfeng Yao, Yao Deng, Hong Chen, Guangwen Lu, Wen Wang, Linlin Bao, Wei Deng, Qiang Wei, George F. Gao, Chuan Qin, Wenjie Tan
Published 2015-10-01

Trimeric protein vaccine based on Beta variant elicits robust immune response against BA.4/5-included SARS-CoV-2 Omicron variants

by Cai He, Li Chen, Jingyun Yang, Zimin Chen, Hong Lei, Weiqi Hong, Xiangrong Song, Li Yang, Jiong Li, Wei Wang, Guobo Shen, Guangwen Lu, Xiawei Wei
Published 2023-03-01

A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS‐CoV‐2 Spike‐Mediated Viral Invasion

by Mengdan Wu, Wei Li, Sheng Lin, Jiaqi Fan, Lele Cui, Yijuan Xiang, Kaiyu Li, Linwei Tang, Yanping Duan, Zimin Chen, Fanli Yang, Weiwei Shui, Guangwen Lu, Ying Lai
Published 2023-10-01

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

by Hong Lei, Aqu Alu, Jingyun Yang, Wenyan Ren, Cai He, Tianxia Lan, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, Guangwen Lu, Xiawei Wei
Published 2022-05-01

A bivalent recombinant vaccine targeting the S1 protein induces neutralizing antibodies against both SARS‐CoV‐2 variants and wild‐type of the virus

by Cai He, Jingyun Yang, Xuemei He, Weiqi Hong, Hong Lei, Zimin Chen, Guobo Shen, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, Guangwen Lu, Xiawei Wei
Published 2021-09-01