Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

by Nicole E. Scharping, Greg M. Delgoffe
Published 2016-12-01

Fighting in a wasteland: deleterious metabolites and antitumor immunity

by McLane J. Watson, Greg M. Delgoffe
Published 2022-01-01

Characteristics of the Tumor Microenvironment That Influence Immune Cell Functions: Hypoxia, Oxidative Stress, Metabolic Alterations

by Ryan C. Augustin, Greg M. Delgoffe, Yana G. Najjar
Published 2020-12-01

89723 CD105-targeted CAR T cells for the treatment of acute myeloid leukemia

by Konstantinos Lontos, Yiyang Wang, Andrew Frisch, Mason Colbert, Jason Lohmueller, Greg M. Delgoffe
Published 2021-03-01

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

by Alicia R. Watson, Alicia R. Watson, Helong Dai, Helong Dai, Yawen Zheng, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Greg M. Delgoffe, Angus W. Thomson, Angus W. Thomson
Published 2019-07-01

Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck

by Greg M Delgoffe, Kristin DePeaux, Angen Liu, Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle
Published 2021-05-01

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

by Stephanie Downs-Canner, Sara Berkey, Greg M. Delgoffe, Robert P. Edwards, Tyler Curiel, Kunle Odunsi, David L. Bartlett, Nataša Obermajer
Published 2017-03-01

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

by Shankar Revu, Jing Wu, Matthew Henkel, Natalie Rittenhouse, Ashley Menk, Greg M. Delgoffe, Amanda C. Poholek, Mandy J. McGeachy
Published 2018-03-01

Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

by Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe
Published 2022-12-01

Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections

by Sidney Lane, Tristan L. A. White, Erin E. Walsh, Richard T. Cattley, Rachel Cumberland, William F. Hawse, Greg M. Delgoffe, Stephen F. Badylak, Jennifer M. Bomberger
Published 2023-10-01

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

by Min Yang, Wenwen Du, Lixian Yi, Shaoxian Wu, Chunyan He, Wensi Zhai, Cuihua Yue, Runzi Sun, Ashley V. Menk, Greg M. Delgoffe, Jingting Jiang, Binfeng Lu
Published 2020-01-01

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

by Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell, Greg M. Delgoffe
Published 2018-02-01

The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy

by Frank P. Vendetti, Pinakin Pandya, David A. Clump, Sandra Schamus-Haynes, Meysam Tavakoli, Maria diMayorca, Naveed M. Islam, Jina Chang, Greg M. Delgoffe, Jan H. Beumer, Christopher J. Bakkenist
Published 2023-02-01

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

by Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa
Published 2023-03-01

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

by Hridesh Banerjee, Hector Nieves-Rosado, Aditi Kulkarni, Benjamin Murter, Kyle V. McGrath, Uma R. Chandran, Alexander Chang, Andrea L. Szymczak-Workman, Lazar Vujanovic, Greg M. Delgoffe, Robert L. Ferris, Lawrence P. Kane
Published 2021-09-01

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

by Dana M. Previte, Christina P. Martins, Erin C. O’Connor, Meghan L. Marre, Gina M. Coudriet, Noah W. Beck, Ashley V. Menk, Rebecca H. Wright, Hubert M. Tse, Greg M. Delgoffe, Jon D. Piganelli
Published 2019-04-01

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection.

by Grace P Carreno-Florez, Brian R Kocak, Matthew R Hendricks, Jeffrey A Melvin, Katrina B Mar, Jessica Kosanovich, Rachel L Cumberland, Greg M Delgoffe, Sruti Shiva, Kerry M Empey, John W Schoggins, Jennifer M Bomberger
Published 2023-11-01

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection

by Grace P. Carreno-Florez, Brian R. Kocak, Matthew R. Hendricks, Jeffrey A. Melvin, Katrina B. Mar, Jessica Kosanovich, Rachel L. Cumberland, Greg M. Delgoffe, Sruti Shiva, Kerry M. Empey, John W. Schoggins, Jennifer M. Bomberger
Published 2023-11-01

Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study

by Ryan C. Augustin, Ryan C. Augustin, Ziyu Huang, Fei Ding, Shuyan Zhai, Jennifer McArdle, Anthony Santisi, Michael Davis, Cindy Sander, Diwakar Davar, John M. Kirkwood, John M. Kirkwood, Greg M. Delgoffe, Allison Betof Warner, Yana G. Najjar, Yana G. Najjar
Published 2023-06-01

Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to DamageSummary

by Ansen H.P. Burr, Junyi Ji, Kadir Ozler, Heather L. Mentrup, Onur Eskiocak, Brian Yueh, Rachel Cumberland, Ashley V. Menk, Natalie Rittenhouse, Chris W. Marshall, Pailin Chiaranunt, Xiaoyi Zhang, Lauren Mullinax, Abigail Overacre-Delgoffe, Vaughn S. Cooper, Amanda C. Poholek, Greg M. Delgoffe, Kevin P. Mollen, Semir Beyaz, Timothy W. Hand
Published 2023-01-01