Editorial: Factors determining long term anti-tumor responses to immune checkpoint blockade therapy

by Roberta Zappasodi, Graham P. Cook, Alison Taylor
Published 2022-12-01

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region.

by Dheeraj Prakaash, Graham P Cook, Oreste Acuto, Antreas C Kalli
Published 2021-07-01

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)

by Dheeraj Prakaash, Charline Fagnen, Graham P. Cook, Oreste Acuto, Antreas C. Kalli
Published 2022-12-01

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

by Aarren J. Mannion, Adam F. Odell, Syed Murtuza Baker, Laura C. Matthews, Pamela F. Jones, Graham P. Cook
Published 2023-04-01

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

by Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Published 2021-06-01

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells

by Helen Carrasco Hope, Helen Carrasco Hope, Gabriella Pickersgill, Pierpaolo Ginefra, Nicola Vannini, Graham P. Cook, Robert J. Salmond
Published 2022-07-01

Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.

by Erica B Wilson, Jehan J El-Jawhari, Abbie L Neilson, Geoffrey D Hall, Alan A Melcher, Josephine L Meade, Graham P Cook
Published 2011-01-01

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.

by Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, Stephen Griffin
Published 2020-08-01