Thalidomide and Phosphodiesterase 4 Inhibitors as Host Directed Therapeutics for Tuberculous Meningitis: Insights From the Rabbit Model

by Ranjeet Kumar, Afsal Kolloli, Pooja Singh, Christopher Vinnard, Gilla Kaplan, Selvakumar Subbian
Published 2020-01-01

A phosphodiesterase-4 inhibitor reduces lung inflammation and fibrosis in a hamster model of SARS-CoV-2 infection

by Afsal Kolloli, Santhamani Ramasamy, Ranjeet Kumar, Annuurun Nisa, Gilla Kaplan, Selvakumar Subbian
Published 2023-10-01

Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection.

by Claudia Manca, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Gilla Kaplan, Selvakumar Subbian
Published 2013-01-01

Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

by Afsal Kolloli, Ranjeet Kumar, Pooja Singh, Anshika Narang, Gilla Kaplan, Alex Sigal, Selvakumar Subbian
Published 2021-11-01

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth

by Patricia L. Semple, Marcia Watkins, Virginia Davids, Alan M. Krensky, Willem A. Hanekom, Gilla Kaplan, Stanley Ress
Published 2011-01-01

A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis.

by Selena Ferrian, Claudia Manca, Sugnet Lubbe, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Clive M Gray, Dorothy Fallows
Published 2017-01-01

Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes.

by Chongzhen Wang, Pascale Peyron, Olga Mestre, Gilla Kaplan, Dick van Soolingen, Qian Gao, Brigitte Gicquel, Olivier Neyrolles
Published 2010-01-01

BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model.

by Amit Singhal, Vanessa Mathys, Mehdi Kiass, Colette Creusy, Baptiste Delaire, El Moukhtar Aliouat, Véronique Dartois, Gilla Kaplan, Pablo Bifani
Published 2011-01-01

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response

by Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, Gilla Kaplan
Published 2011-01-01

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

by Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan
Published 2016-02-01

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

by Elizabeth A Misch, Murdo Macdonald, Chaman Ranjit, Bishwa R Sapkota, Richard D Wells, M Ruby Siddiqui, Gilla Kaplan, Thomas R Hawn
Published 2008-05-01

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs.

by Selvakumar Subbian, Liana Tsenova, Paul O'Brien, Guibin Yang, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Veronique Dartois, George Muller, Gilla Kaplan
Published 2011-09-01

‘ZS-MDR-TB’ versus ‘ZR-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

by Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson, Wenhong Zhang
Published 2012-07-01

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

by Mi-Sun Koo, Claudia Manca, Guibin Yang, Paul O'Brien, Nackmoon Sung, Liana Tsenova, Selvakumar Subbian, Dorothy Fallows, George Muller, Sabine Ehrt, Gilla Kaplan
Published 2011-02-01

Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis.

by Catherine Riou, Blas Perez Peixoto, Lindi Roberts, Katharina Ronacher, Gerhard Walzl, Claudia Manca, Roxana Rustomjee, Thuli Mthiyane, Dorothy Fallows, Clive M Gray, Gilla Kaplan
Published 2012-01-01

Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to C...

by Selena Ferrian, Melinda Ross, Francesca Conradie, Shaheed Vally Omar, Nazir Ismail, Nazir Ismail, Francesca Little, Gilla Kaplan, Dorothy Fallows, Clive M. Gray, Clive M. Gray
Published 2018-10-01

Induction of ER stress in macrophages of tuberculosis granulomas.

by Tracie A Seimon, Mi-Jeong Kim, Antje Blumenthal, Jovanka Koo, Sabine Ehrt, Helen Wainwright, Linda-Gail Bekker, Gilla Kaplan, Carl Nathan, Ira Tabas, David G Russell
Published 2010-09-01

Correlation of rpoB mutations with minimal inhibitory concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS endemic setting, South Africa

by Ivy - Rukasha, Halima Mohammed Said, Halima Mohammed Said, Shaheed Vally Omar, Hendrik - Koornhoof, Andries W Dreyer, Alfred - Musekiwa, Harry Moultrie, Anwar A Hoosen, Gilla Kaplan, Dorothy Fallows, Nazir Ismail
Published 2016-12-01

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study.

by Selvakumar Subbian, Liana Tsenova, Mi-Jeong Kim, Helen C Wainwright, Annalie Visser, Nirmalya Bandyopadhyay, Joel S Bader, Petros C Karakousis, Gabriele B Murrmann, Linda-Gail Bekker, David G Russell, Gilla Kaplan
Published 2015-01-01

A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings.

by Halima M Said, Nicole Kushner, Shaheed V Omar, Andries W Dreyer, Hendrik Koornhof, Linda Erasmus, Yasmin Gardee, Ivy Rukasha, Elena Shashkina, Natalie Beylis, Gilla Kaplan, Dorothy Fallows, Nazir A Ismail
Published 2016-01-01