On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

by Petersen Ann-Kristin, Krumsiek Jan, Wägele Brigitte, Theis Fabian J, Wichmann H-Erich, Gieger Christian, Suhre Karsten
Published 2012-06-01

Human gene expression sensitivity according to large scale meta-analysis

by Tu Kang, Ping Jie, Zheng Siyuan, Hao Pei, Gieger Christian, Wang-Sattler Rui, Zhong Yang, Li Yixue
Published 2009-01-01

CONAN: copy number variation analysis software for genome-wide association studies

by Wichmann Heinz-Erich, Gieger Christian, Kluckner Thomas, Haider Florian, Weissensteiner Hansi, Schönherr Sebastian, Forer Lukas, Specht Günther, Kronenberg Florian, Kloss-Brandstätter Anita
Published 2010-06-01

Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays

by Gieger Christian, Roshyara Nab R, Ahnert Peter, Veeramah Krishna R, Kovacs Peter, Tönjes Anke, Gross Arnd, Rueckert Ina-Maria, Loeffler Markus, Stoneking Mark, Wichmann Heinz-Erich, Novembre John, Stumvoll Michael, Scholz Markus
Published 2011-07-01

Novel <it>SCARB2 </it>mutation in action myoclonus-renal failure syndrome and evaluation of <it>SCARB2 </it>mutations in isolated AMRF features

by Hopfner Franziska, Schormair Barbara, Knauf Franziska, Berthele Achim, Tölle Thomas R, Baron Ralf, Maier Christoph, Treede Rolf-Detlef, Binder Andreas, Sommer Claudia, Maihöfner Christian, Kunz Wolfram, Zimprich Friedrich, Heemann Uwe, Pfeufer Arne, Näbauer Michael, Kääb Stefan, Nowak Barbara, Gieger Christian, Lichtner Peter, Trenkwalder Claudia, Oexle Konrad, Winkelmann Juliane
Published 2011-10-01

Genome-wide methylation data mirror ancestry information.

by Rahmani, Elior, Shenhav, Liat, Schweiger, Regev, Yousefi, Paul, Huen, Karen, Eskenazi, Brenda, Eng, Celeste, Huntsman, Scott, Hu, Donglei, Galanter, Joshua, Oh, Sam S, Waldenberger, Melanie, Strauch, Konstantin, Grallert, Harald, Meitinger, Thomas, Gieger, Christian, Holland, Nina, Burchard, Esteban G, Zaitlen, Noah, Halperin, Eran
Published 2017

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

by Surakka, Ida, Isaacs, Aaron, Karssen, Lennart, Laurila, Pirkka-Pekka, Middelberg, Rita, Tikkanen, Emmi, Ried, Janina, Lamina, Claudia, Mangino, Massimo, Igl, Wilmar, Hottenga, Jouke-Jan, Lagou, Vasiliki, van der Harst, Pim, Leach, Irene Mateo, Tõnu Esko, Zoltán Kutalik, Wainwright, Nicholas, Struchalin, Maksim, Sarin, Antti-Pekka, Kangas, Antti, Viikari, Jorma, Perola, Markus, Rantanen, Taina, Petersen, Ann-Kristin, Soininen, Pasi, Åsa Johansson, Soranzo, Nicole, Heath, Andrew, Papamarkou, Theodore, Prokopenko, Inga, Tönjes, Anke, Kronenberg, Florian, Döring, Angela, Rivadeneira, Fernando, Montgomery, Grant, Whitfield, John, Kähönen, Mika, Lehtimäki, Terho, Freimer, Nelson, Willemsen, Gonneke, de Geus, Eco J. C., Palotie, Aarno, Sandhu, Manj, Waterworth, Dawn, Metspalu, Andres, Stumvoll, Michael, Uitterlinden, André G., Jula, Antti, Navis, Gerjan, Wijmenga, Cisca, Wolffenbuttel, Bruce, Taskinen, Marja-Riitta, Ala-Korpela, Mika, Kaprio, Jaakko, Kyvik, Kirsten, Boomsma, Dorret, Pedersen, Nancy, Gyllensten, Ulf, Wilson, James, Rudan, Igor, Campbell, Harry, Pramstaller, Peter, Spector, Tim, Witteman, Jacqueline, Eriksson, Johan, Salomaa, Veikko, Oostra, Ben, Raitakari, Olli, Wichmann, H.-Erich, Gieger, Christian, Marjo-Riitta Järvelin, Martin, Nicholas, Hofman, Albert, McCarthy, Mark, Peltonen, Leena, van Duijn, Cornelia M., Aulchenko, Yurii, Ripatti, Samuli
Published 2019

Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

by Ward-Caviness, Cavin K., Agha, Golareh, Chen, Brian H., Pfeiffer, Liliane, Wilson, Rory, Wolf, Petra, Gieger, Christian, Schwartz, Joel, Vokonas, Pantel S., Hou, Lifang, Just, Allan C., Bandinelli, Stefania, Hernandez, Dena G., Singleton, Andrew B., Prokisch, Holger, Meitinger, Thomas, Kastenmüller, Gabi, Ferrucci, Luigi, Baccarelli, Andrea A., Waldenberger, Melanie, Peters, Annette
Published 2018

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

by Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei
Published 2017

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

by Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B, Laser, Annika, Maranville, Joseph C, Wu, Hongsheng, Ho, Jennifer E, Courchesne, Paul, Lyass, Asya, Larson, Martin G, Gieger, Christian, Graumann, Johannes, Johnson, Andrew D, Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S, Suhre, Karsten, Levy, Daniel
Published 2018

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

by Schumann, Gunter, Liu, Chunyu, O’Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Lepe, Marcelo Segura, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hällfors, Jenni, Harris, Sarah, Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Åsa Johansson, Joshi, Peter, Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu, Jian’an Luan, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Mbarek, Hamdi, Milaneschi, Yuri, Moayyeri, Alireza, Mukamal, Kenneth, Nelson, Christopher, Nettleton, Jennifer, Partinen, Eemil, Rawal, Rajesh, Robino, Antonietta, Rose, Lynda, Sala, Cinzia, Satoh, Takashi, Schmidt, Reinhold, Schraut, Katharina, Scott, Robert, Smith, Albert Vernon, Starr, John, Teumer, Alexander, Trompet, Stella, Uitterlinden, André G., Venturini, Cristina, Vergnaud, Anne-Claire, Verweij, Niek, Vitart, Veronique, Vuckovic, Dragana, Wedenoja, Juho, Yengo, Loic, Yu, Bing, Zhang, Weihua, Zhao, Jing Hua, Boomsma, Dorret, Chambers, John, Chasman, Daniel, Daniela, Toniolo, de Geus, Eco, Deary, Ian, Eriksson, Johan, Tõnu Esko, Eulenburg, Volker, Franco, Oscar, Froguel, Philippe, Gieger, Christian, Grabe, Hans, Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara, Hartikainen, Anna-Liisa, Heath, Andrew, Hocking, Lynne, Hofman, Albert, Huth, Cornelia, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kaprio, Jaakko, Kooner, Jaspal, Kutalik, Zoltan, Lahti, Jari, Langenberg, Claudia, Lehtimäki, Terho, Liu, Yongmei, Madden, Pamela, Martin, Nicholas, Morrison, Alanna, Penninx, Brenda, Pirastu, Nicola, Psaty, Bruce, Raitakari, Olli
Published 2019

Human serum metabolic profiles are age dependent

by Yu, Zhonghao, Zhai, Guangju, Singmann, Paula, He, Ying, Xu, Tao, Prehn, Cornelia, Römisch-Margl, Werner, Lattka, Eva, Gieger, Christian, Soranzo, Nicole, Heinrich, Joachim, Standl, Marie, Thiering, Elisabeth, Mittelstraß, Kirstin, Wichmann, Heinz-Erich, Peters, Annette, Suhre, Karsten, Li, Yixue, Adamski, Jerzy, Spector, Tim D, Illig, Thomas, Wang-Sattler, Rui
Published 2013

Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases.

by Li, Yong, Cheng, Yurong, Consolato, Francesco, Schiano, Guglielmo, Chong, Michael R, Pietzner, Maik, Nguyen, Ngoc Quynh H, Scherer, Nora, Biggs, Mary L, Kleber, Marcus E, Haug, Stefan, Göçmen, Burulça, Pigeyre, Marie, Sekula, Peggy, Steinbrenner, Inga, Schlosser, Pascal, Joseph, Christina B, Brody, Jennifer A, Grams, Morgan E, Hayward, Caroline, Schultheiss, Ulla T, Krämer, Bernhard K, Kronenberg, Florian, Peters, Annette, Seissler, Jochen, Steubl, Dominik, Then, Cornelia, Wuttke, Matthias, März, Winfried, Eckardt, Kai-Uwe, Gieger, Christian, Boerwinkle, Eric, Psaty, Bruce M, Coresh, Josef, Oefner, Peter J, Pare, Guillaume, Langenberg, Claudia, Scherberich, Jürgen E, Yu, Bing, Akilesh, Shreeram, Devuyst, Olivier, Rampoldi, Luca, Köttgen, Anna
Published 2022

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.

by Benyamin, Beben, Esko, Tonu, Ried, Janina S, Radhakrishnan, Aparna, Vermeulen, Sita H, Traglia, Michela, Gögele, Martin, Anderson, Denise, Broer, Linda, Podmore, Clara, Luan, Jian'an, Kutalik, Zoltan, Sanna, Serena, van der Meer, Peter, Tanaka, Toshiko, Wang, Fudi, Westra, Harm-Jan, Franke, Lude, Mihailov, Evelin, Milani, Lili, Hälldin, Jonas, Winkelmann, Juliane, Meitinger, Thomas, Thiery, Joachim, Peters, Annette, Waldenberger, Melanie, Rendon, Augusto, Jolley, Jennifer, Sambrook, Jennifer, Kiemeney, Lambertus A, Sweep, Fred C, Sala, Cinzia F, Schwienbacher, Christine, Pichler, Irene, Hui, Jennie, Demirkan, Ayse, Isaacs, Aaron, Amin, Najaf, Steri, Maristella, Waeber, Gérard, Verweij, Niek, Powell, Joseph E, Nyholt, Dale R, Heath, Andrew C, Madden, Pamela AF, Visscher, Peter M, Wright, Margaret J, Montgomery, Grant W, Martin, Nicholas G, Hernandez, Dena, Bandinelli, Stefania, van der Harst, Pim, Uda, Manuela, Vollenweider, Peter, Scott, Robert A, Langenberg, Claudia, Wareham, Nicholas J, InterAct Consortium, van Duijn, Cornelia, Beilby, John, Pramstaller, Peter P, Hicks, Andrew A, Ouwehand, Willem H, Oexle, Konrad, Gieger, Christian, Metspalu, Andres, Camaschella, Clara, Toniolo, Daniela, Swinkels, Dorine W, Whitfield, John B
Published 2018

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

by Kettunen, Johannes, Demirkan, Ayşe, Würtz, Peter, Draisma, Harmen H.M., Haller, Toomas, Rawal, Rajesh, Vaarhorst, Anika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Pirinen, Matti, Pool, René, Sarin, Antti-Pekka, Soininen, Pasi, Tukiainen, Taru, Wang, Qin, Tiainen, Mika, Tynkkynen, Tuulia, Amin, Najaf, Zeller, Tanja, Beekman, Marian, Deelen, Joris, van Dijk, Ko Willems, Esko, Tõnu, Hottenga, Jouke-Jan, van Leeuwen, Elisabeth M, Lehtimäki, Terho, Mihailov, Evelin, Rose, Richard J., de Craen, Anton J.M., Gieger, Christian, Kähönen, Mika, Perola, Markus, Blankenberg, Stefan, Savolainen, Markku J., Verhoeven, Aswin, Viikari, Jorma, Willemsen, Gonneke, Boomsma, Dorret I., van Duijn, Cornelia M., Eriksson, Johan, Jula, Antti, Järvelin, Marjo-Riitta, Kaprio, Jaakko, Metspalu, Andres, Raitakari, Olli, Salomaa, Veikko, Slagboom, P. Eline, Waldenberger, Melanie, Ripatti, Samuli, Ala-Korpela, Mika
Published 2016

Long-term exposure to air pollution is associated with biological aging

by Ward-Caviness, Cavin K., Nwanaji-Enwerem, Jamaji C., Wolf, Kathrin, Wahl, Simone, Colicino, Elena, Trevisi, Letizia, Kloog, Itai, Just, Allan C., Vokonas, Pantel, Cyrys, Josef, Gieger, Christian, Schwartz, Joel, Baccarelli, Andrea A., Schneider, Alexandra, Peters, Annette
Published 2017

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

by Saunders, Sean P, Goh, Christabelle SM, Brown, Sara J, Palmer, Colin NA, Porter, Rebecca M, Cole, Christian, Campbell, Linda E, Gierlinski, Marek, Barton, Geoffrey J, Schneider, Georg, Balmain, Allan, Prescott, Alan R, Weidinger, Stephan, Baurecht, Hansjörg, Kabesch, Michael, Gieger, Christian, Lee, Young-Ae, Tavendale, Roger, Mukhopadhyay, Somnath, Turner, Stephen W, Madhok, Vishnu B, Sullivan, Frank M, Relton, Caroline, Burn, John, Meggitt, Simon, Smith, Catherine H, Allen, Michael A, Barker, Jonathan NWN, Reynolds, Nick J, Cordell, Heather J, Irvine, Alan D, McLean, WH Irwin, Sandilands, Aileen, Fallon, Padraic G
Published 2013

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

by Nowak, Christoph, Salihovic, Samira, Ganna, Andrea, Brandmaier, Stefan, Tukiainen, Taru, Broeckling, Corey D., Magnusson, Patrik K., Prenni, Jessica E., Wang-Sattler, Rui, Peters, Annette, Strauch, Konstantin, Meitinger, Thomas, Giedraitis, Vilmantas, Ärnlöv, Johan, Berne, Christian, Gieger, Christian, Ripatti, Samuli, Lind, Lars, Pedersen, Nancy L., Sundström, Johan, Ingelsson, Erik, Fall, Tove
Published 2016

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

by Sundqvist, Emilie, Buck, Dorothea, Warnke, Clemens, Albrecht, Eva, Gieger, Christian, Khademi, Mohsen, Lima Bomfim, Izaura, Fogdell-Hahn, Anna, Link, Jenny, Alfredsson, Lars, Søndergaard, Helle Bach, Hillert, Jan, International Multiple Sclerosis Genetics Consortium, Oturai, Annette B, Hemmer, Bernhard, Kockum, Ingrid, Olsson, Tomas
Published 2014

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

by Schumann, Gunter, Liu, Chunyu, O'Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Segura Lepe, Marcelo, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hällfors, Jenni, Harris, Sarah E, Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Åsa, Joshi, Peter K, Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Mbarek, Hamdi, Milaneschi, Yuri, Moayyeri, Alireza, Mukamal, Kenneth, Nelson, Christopher, Nettleton, Jennifer, Partinen, Eemil, Rawal, Rajesh, Robino, Antonietta, Rose, Lynda, Sala, Cinzia, Satoh, Takashi, Schmidt, Reinhold, Schraut, Katharina, Scott, Robert, Smith, Albert Vernon, Starr, John M, Teumer, Alexander, Trompet, Stella, Uitterlinden, André G, Venturini, Cristina, Vergnaud, Anne-Claire, Verweij, Niek, Vitart, Veronique, Vuckovic, Dragana, Wedenoja, Juho, Yengo, Loic, Yu, Bing, Zhang, Weihua, Zhao, Jing Hua, Boomsma, Dorret I, Chambers, John, Chasman, Daniel I, Daniela, Toniolo, de Geus, Eco, Deary, Ian, Eriksson, Johan G, Esko, Tõnu, Eulenburg, Volker, Franco, Oscar H, Froguel, Philippe, Gieger, Christian, Grabe, Hans J, Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B, Hartikainen, Anna-Liisa, Heath, Andrew C, Hocking, Lynne, Hofman, Albert, Huth, Cornelia, Jarvelin, Marjo-Riitta, Jukema, J Wouter, Kaprio, Jaakko, Kooner, Jaspal S, Kutalik, Zoltan, Lahti, Jari, Langenberg, Claudia, Lehtimäki, Terho, Liu, Yongmei, Madden, Pamela AF, Martin, Nicholas, Morrison, Alanna, Penninx, Brenda, Pirastu, Nicola, Psaty, Bruce, Raitakari, Olli
Published 2016