Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

by Lukas Villiger, Lukas Schmidheini, Nicolas Mathis, Tanja Rothgangl, Kim Marquart, Gerald Schwank
Published 2021-12-01

Generation of BAC transgenic epithelial organoids.

by Gerald Schwank, Amanda Andersson-Rolf, Bon-Kyoung Koo, Nobuo Sasaki, Hans Clevers
Published 2013-01-01

In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells

by Nataša Savić, Femke Ringnalda, Christian Berk, Katja Bargsten, Jonathan Hall, Martin Jinek, Gerald Schwank
Published 2019-01-01

Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens

by Kim F. Marquart, Ahmed Allam, Sharan Janjuha, Anna Sintsova, Lukas Villiger, Nina Frey, Michael Krauthammer, Gerald Schwank
Published 2021-08-01

Formation of the long range Dpp morphogen gradient.

by Gerald Schwank, Sascha Dalessi, Schu-Fee Yang, Ryohei Yagi, Aitana Morton de Lachapelle, Markus Affolter, Sven Bergmann, Konrad Basler
Published 2011-07-01

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

by Nina Frey, Luigi Tortola, David Egli, Sharan Janjuha, Tanja Rothgangl, Kim Fabiano Marquart, Franziska Ampenberger, Manfred Kopf, Gerald Schwank
Published 2022-04-01

In vivo targeting of a variant causing vanishing white matter using CRISPR/Cas9

by Anne E.J. Hillen, Martina Hruzova, Tanja Rothgangl, Marjolein Breur, Marianna Bugiani, Marjo S. van der Knaap, Gerald Schwank, Vivi M. Heine
Published 2022-06-01

miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine

by Algera Goga, Büsra Yagabasan, Karolin Herrmanns, Svenja Godbersen, Pamuditha N. Silva, Remy Denzler, Mirjam Zünd, Markus Furter, Gerald Schwank, Shinichi Sunagawa, Wolf-Dietrich Hardt, Markus Stoffel
Published 2021-06-01

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

by Natasa Savic, Femke CAS Ringnalda, Helen Lindsay, Christian Berk, Katja Bargsten, Yizhou Li, Dario Neri, Mark D Robinson, Constance Ciaudo, Jonathan Hall, Martin Jinek, Gerald Schwank
Published 2018-05-01

Mutant SF3B1 promotes malignancy in PDAC

by Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank
Published 2023-10-01

Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

by Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
Published 2023-08-01

Enhancing prime editor activity by directed protein evolution in yeast

by Yanik Weber, Desirée Böck, Anastasia Ivașcu, Nicolas Mathis, Tanja Rothgangl, Eleonora I. Ioannidi, Alex C. Blaudt, Lisa Tidecks, Máté Vadovics, Hiromi Muramatsu, Andreas Reichmuth, Kim F. Marquart, Lucas Kissling, Norbert Pardi, Martin Jinek, Gerald Schwank
Published 2024-03-01

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy

by Christian K. Hirt, Tijmen H. Booij, Linda Grob, Patrik Simmler, Nora C. Toussaint, David Keller, Doreen Taube, Vanessa Ludwig, Alexander Goryachkin, Chantal Pauli, Daniela Lenggenhager, Daniel J. Stekhoven, Christian U. Stirnimann, Katharina Endhardt, Femke Ringnalda, Lukas Villiger, Alexander Siebenhüner, Sofia Karkampouna, Marta De Menna, Janette Beshay, Hagen Klett, Marianna Kruithof-de Julio, Julia Schüler, Gerald Schwank
Published 2022-02-01