Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death

by Olivia J. Marola, Gareth R. Howell, Richard T. Libby
Published 2022-04-01

The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

by Kate E. Foley, Kate E. Foley, Amanda A. Hewes, Amanda A. Hewes, Dylan T. Garceau, Kevin P. Kotredes, Gregory W. Carter, Gregory W. Carter, Gregory W. Carter, Michael Sasner, Gareth R. Howell, Gareth R. Howell, Gareth R. Howell
Published 2022-03-01

Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice

by Kate E. Foley, Hongtian Stanley Yang, Leah C. Graham, Gareth R. Howell
Published 2019-11-01

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease

by Ravi S. Pandey, Kevin P. Kotredes, Michael Sasner, Gareth R. Howell, Gregory W. Carter
Published 2023-04-01

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

by Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell, Gregory W. Carter
Published 2019-12-01

Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.

by Ryan H Berry, Juan Qu, Simon W M John, Gareth R Howell, Tatjana C Jakobs
Published 2015-01-01

Transcriptional control of retinal ganglion cell death after axonal injury

by Stephanie B. Syc-Mazurek, Hongtian Stanley Yang, Olivia J. Marola, Gareth R. Howell, Richard T. Libby
Published 2022-03-01

APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factors

by Kate E. Foley, Cory A. Diemler, Amanda A. Hewes, Dylan T. Garceau, Michael Sasner, Gareth R. Howell
Published 2022-01-01

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

by Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Published 2019-08-01

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

by Ileana Soto, Gareth R Howell, Cai W John, Joseph L Kief, Richard T Libby, Simon W M John
Published 2014-01-01

Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

by Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J. Keezer, Daniel A. Skelly, Gregory W. Carter, Gareth R. Howell
Published 2021-02-01

A novel mouse model expressing human forms for complement receptors CR1 and CR2

by Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Published 2020-09-01

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

by Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John
Published 2014-11-01

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

by Pete A Williams, Gareth R Howell, Jessica M Barbay, Catherine E Braine, Gregory L Sousa, Simon W M John, James E Morgan
Published 2013-01-01

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

by Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell
Published 2020-11-01

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

by Laura G Reinholdt, Gareth R Howell, Anne M Czechanski, Danilo G Macalinao, Katharine H Macnicoll, Chyuan-Sheng Lin, Leah Rae Donahue, Simon W M John
Published 2012-01-01

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

by Ileana Soto, Leah C Graham, Hannah J Richter, Stephen N Simeone, Jake E Radell, Weronika Grabowska, W Keith Funkhouser, Megan C Howell, Gareth R Howell
Published 2015-10-01

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

by Harriet M Jackson, Kristen D Onos, Keating W Pepper, Leah C Graham, Ellen C Akeson, Candice Byers, Laura G Reinholdt, Wayne N Frankel, Gareth R Howell
Published 2015-01-01

Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

by Larisa Kavetsky, Kayla K. Green, Bridget R. Boyle, Fawad A. K. Yousufzai, Zachary M. Padron, Sierra E. Melli, Victoria L. Kuhnel, Harriet M. Jackson, Rosa E. Blanco, Gareth R. Howell, Ileana Soto
Published 2019-10-01

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

by Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Published 2019-01-01