Polymerase θ inhibition steps on the cGAS pedal

by Chelsea M. Smith, Gaorav P. Gupta
Published 2023-06-01

Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

by Megan E. Luedeman, Susanna Stroik, Wanjuan Feng, Adam J. Luthman, Gaorav P. Gupta, Dale A. Ramsden
Published 2022-08-01

Immune-Mediated Effects of Microplanar Radiotherapy with a Small Animal Irradiator

by Soha Bazyar, Edward Timothy O’Brien, Thad Benefield, Victoria R. Roberts, Rashmi J. Kumar, Gaorav P. Gupta, Otto Zhou, Yueh Z. Lee
Published 2021-12-01

Genetic determinants of cellular addiction to DNA polymerase theta

by Wanjuan Feng, Dennis A. Simpson, Juan Carvajal-Garcia, Brandon A. Price, Rashmi J. Kumar, Lisle E. Mose, Richard D. Wood, Naim Rashid, Jeremy E. Purvis, Joel S. Parker, Dale A. Ramsden, Gaorav P. Gupta
Published 2019-09-01

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

by Katerina D. Fagan-Solis, Dennis A. Simpson, Rashmi J. Kumar, Luciano G. Martelotto, Lisle E. Mose, Naim U. Rashid, Alice Y. Ho, Simon N. Powell, Y. Hannah Wen, Joel S. Parker, Jorge S. Reis-Filho, John H.J. Petrini, Gaorav P. Gupta
Published 2020-02-01

Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities

by John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Published 2023-11-01

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

by Joseph Nacson, John J. Krais, Andrea J. Bernhardy, Emma Clausen, Wanjuan Feng, Yifan Wang, Emmanuelle Nicolas, Kathy Q. Cai, Rossella Tricarico, Xiang Hua, Daniela DiMarcantonio, Esteban Martinez, Dali Zong, Elizabeth A. Handorf, Alfonso Bellacosa, Joseph R. Testa, Andre Nussenzweig, Gaorav P. Gupta, Stephen M. Sykes, Neil Johnson
Published 2018-09-01

Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

by Sm N. Udden, Qian Wang, Sunil Kumar, Venkat S. Malladi, Shwu-Yuan Wu, Shuguang Wei, Bruce A. Posner, Sophie Geboers, Noelle S. Williams, Yulun Liu, Jayesh K. Sharma, Ram S. Mani, Srinivas Malladi, Karla Parra, Mia Hofstad, Ganesh V. Raj, Jose M. Larios, Reshma Jagsi, Max S. Wicha, Ben Ho Park, Gaorav P. Gupta, Arul M. Chinnaiyan, Cheng-Ming Chiang, Prasanna G. Alluri
Published 2022-09-01

TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer

by Filipa Lynce, Laura E. Stevens, Zheqi Li, Jane E. Brock, Anushree Gulvady, Ying Huang, Faina Nakhlis, Ashka Patel, Jeremy M. Force, Tufia C. Haddad, Naoto Ueno, Vered Stearns, Antonio C. Wolff, Amy S. Clark, Jennifer R. Bellon, Edward T. Richardson, Justin M. Balko, Ian E. Krop, Eric P. Winer, Paulina Lange, E. Shelley Hwang, Tari A. King, Sara M. Tolaney, Alastair Thompson, Gaorav P. Gupta, Elizabeth A. Mittendorf, Meredith M. Regan, Beth Overmoyer, Kornelia Polyak
Published 2024-01-01