IBtkα Activates the β-Catenin-Dependent Transcription of <i>MYC</i> through Ubiquitylation and Proteasomal Degradation of GSK3β in Cancerous B Cells

by Eleonora Vecchio, Nancy Nisticò, Gaetanina Golino, Enrico Iaccino, Domenico Maisano, Selena Mimmi, Annamaria Aloisio, Maurizio Renna, Angelica Avagliano, Alessandro Arcucci, Giuseppe Fiume, Ileana Quinto
Published 2022-02-01

Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma

by Filippo Spriano, Giulio Sartori, Chiara Tarantelli, Marilia Barreca, Gaetanina Golino, Andrea Rinaldi, Sara Napoli, Michele Mascia, Lorenzo Scalise, Alberto J. Arribas, Luciano Cascione, Emanuele Zucca, Anastasios Stathis, Eugenio Gaudio, Francesco Bertoni
Published 2022-08-01

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes

by Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto, Giuseppe Scala
Published 2017-10-01

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

by Daniele Caracciolo, Francesca Scionti, Giada Juli, Emanuela Altomare, Gaetanina Golino, Katia Todoerti, Katia Grillone, Caterina Riillo, Mariamena Arbitrio, Michelangelo Iannone, Eugenio Morelli, Nicola Amodio, Maria Teresa Di Martino, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone
Published 2020-02-01

IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells

by Giuseppe Fiume, Annarita Scialdone, Francesca Rizzo, Maria Rosaria De Filippo, Carmelo Laudanna, Francesco Albano, Gaetanina Golino, Eleonora Vecchio, Marilena Pontoriero, Selena Mimmi, Simona Ceglia, Antonio Pisano, Enrico Iaccino, Camillo Palmieri, Sergio Paduano, Giuseppe Viglietto, Alessandro Weisz, Giuseppe Scala, Ileana Quinto
Published 2016-11-01

Targeting CD19-positive lymphomas with the antibody-drug conjugate loncastuximab tesirine: preclinical evidence as single agent and in combination therapy

by Chiara Tarantelli, David Wald, Nicolas Munz, Filippo Spriano, Alessio Bruscaggin, Eleonora Cannas, Luciano Cascione, Eugenio Gaudio, Alberto J. Arribas, Shivaprasad Manjappa, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Giorgio Inghirami, Patrick H. van Berkel, Davide Rossi, Paolo F. Caimi, Francesca Zammarchi, Francesco Bertoni
Published 2024-05-01

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models

by Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni
Published 2020-01-01

Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia

by Daniele Caracciolo, Antonio Giordano, Pierfrancesco Tassone, Caterina Riillo, Andrea Ballerini, Giuseppe Gaipa, Ludovic Lhermitte, Marco Rossi, Eugénie Duroyon, Katia Grillone, Maria Eugenia Gallo Cantafio, Chiara Buracchi, Greta Alampi, Alessandro Gulino, Beatrice Belmonte, Francesco Conforti, Gaetanina Golino, Giada Juli, Emanuela Altomare, Nicoletta Polerà, Francesca Scionti, Mariamena Arbitrio, Michelangelo Iannone, Massimo Martino, Gabriella Talarico, Andrea Ghelli Luserna di Rorà, Anna Ferrari, Simona Sestito, Licia Pensabene, Markus Hildinger, Maria Teresa Di Martino, Giovanni Martinelli, Claudio Tripodo, Vahid Asnafi
Published 2021-02-01

A first-in-class Wiskott-Aldrich syndrome protein activator with anti-tumor activity in hematologic cancers

by Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J. Arribas, Matilde Guala, Ana Maria Carrasco Del Amor, Meagan R. Tomasso, Chiara Tarantelli, Luciano Cascione, Gaetanina Golino, Maria E Riveiro, Roberta Bortolozzi, Antonio Lupia, Francesco Paduano, Samuel Huguet, Keyvan Rezai, Andrea Rinaldi, Francesco Margheriti, Pedro Ventura, Greta Guarda, Giosuè Costa, Roberta Rocca, Alberto Furlan, Luuk M. Verdonk, Paolo Innocenti, Nathaniel I. Martin, Giampietro Viola, Christoph Driessen, Emanuele Zucca, Anastasios Stathis, Digvijay Gahtory, Maurits van den Nieuwboer, Beat Bornhauser, Stefano Alcaro, Francesco Trapasso, Susana Cristobal, Shae B. Padrick, Natalina Pazzi, Franco Cavalli, Andrea Cavalli, Eugenio Gaudio, Francesco Bertoni
Published 2024-06-01