A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

by Scott, R.A., Freitag, D.F., Li, L., Chu, A.Y., Surendran, P., Young, R., Grarup, N., Stancakova, A., Chen, Y.N., Varga, T.V., Yaghootkar, H., Luan, J.A., Zhao, J.H., Willems, S.M., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., Lee, S.J. van der, Gillson, C., Olama, A.A. al, Amouyel, P., Arriola, L., Arveiler, D., Aviles-Olmos, I., Balkau, B., Barricarte, A., Barroso, I., Garcia, S.B., Bis, J.C., Blankenberg, S., Boehnke, M., Boeing, H., Boerwinkle, E., Borecki, I.B., Bork-Jensen, J., Bowden, S., Caldas, C., Caslake, M., Cupples, L.A., Cruchaga, C., Czajkowski, J., Hoed, M. den, Dunn, J.A., Earl, H.M., Ehret, G.B., Ferrannini, E., Ferrieres, J., Foltynie, T., Ford, I., Forouhi, N.G., Gianfagna, F., Gonzalez, C., Grioni, S., Hiller, L., Jansson, J.H., Jorgensen, M.E., Jukema, J.W., Kaaks, R., Kee, F., Kerrison, N.D., Key, T.J., Kontto, J., Kote-Jarai, Z., Kraja, A.T., Kuulasmaa, K., Kuusisto, J., Linneberg, A., Liu, C.Y., Marenne, G., Mohlke, K.L., Morris, A.P., Muir, K., Muller-Nurasyid, M., Munroe, P.B., Navarro, C., Nielsen, S.F., Nilsson, P.M., Nordestgaard, B.G., Packard, C.J., Palli, D., Panico, S., Peloso, G.M., Perola, M., Peters, A., Poole, C.J., Quiros, J.R., Rolandsson, O., Sacerdote, C., Salomaa, V., Sanchez, M.J., Sattar, N., Sharp, S.J., Sims, R., Slimani, N., Smith, J.A., Thompson, D.J., Trompet, S., Tumino, R., , D.L. van der a, Schouw, Y.T. van der, Virtamo, J., Walker, M., Walter, K., Abraham, J.E., Amundadottir, L.T., Aponte, J.L., Butterworth, A., Dupuis, J., Easton, D.F., Eeles, R.A., Erdmann, J., Franks, P.W., Frayling, T.M., Hansen, T., Howson, J.M.M., Jorgensen, T., Kooner, J., Laakso, M., Langenberg, C., McCarthy, M.I., Pankow, J.S., Pedersen, O., Riboli, E., Rotter, J.I., Saleheen, D., Samani, N.J., Schunkert, H., Vollenweider, P., O'Rahilly, S., Deloukas, P., Danesh, J., Goodarzi, M.O., Kathiresan, S., Meigs, J.B., Ehm, M.G., Wareham, N.J., Waterworth, D.M., CVD50 Consortium, GERAD-EC Consortium, Neurology Working Grp, CHARGE, Alzheimer's Dis Genetics Consortiu, Pancreatic Canc Cohort Consortium, European Prospective Invest Into C, EPIC-InterAct, CHARGE Consortium, CHD Exome Consortium, CARDIOGRAM Exome Consortium
Published 2016

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

by Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niels, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian'an, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, van der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles-Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork-Jensen, Jette, Bowden, Sarah, Caldas, Carlos, Caslake, Muriel, CVD50 consortium, Cupples, L Adrienne, Cruchaga, Carlos, Czajkowski, Jacek, den Hoed, Marcel, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thomas, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlos, Grioni, Sara, Hiller, Louise, Jansson, Jan-Håkan, Jørgensen, Marit E, Jukema, J Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote-Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller-Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Markus, Peters, Annette, Poole, Christopher J, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María-José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, Trompet, Stella, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, Virtamo, Jarmo, Walker, Mark, Walter, Klaudia, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Aging Research in Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, Abraham, Jean E, Amundadottir, Laufey T, Aponte, Jennifer L, Butterworth, Adam S, Dupuis, Josée, Easton, Douglas F, Eeles, Rosalind A, Erdmann, Jeanette, Franks, Paul W, Frayling, Timothy M, Hansen, Torben, Howson, Joanna MM, Jørgensen, Torben, Kooner, Jaspal, Laakso, Markku, Langenberg, Claudia, McCarthy, Mark I, Pankow, James S, Pedersen, Oluf, Riboli, Elio, Rotter, Jerome I, Saleheen, Danish, Samani, Nilesh J, Schunkert, Heribert, Vollenweider, Peter, O'Rahilly, Stephen, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Deloukas, Panos, Danesh, John, Goodarzi, Mark O, Kathiresan, Sekar, Meigs, James B, Ehm, Margaret G, Wareham, Nicholas J, Waterworth, Dawn M
Published 2016