Perspectives for the Development of CD38-Specific Heavy Chain Antibodies as Therapeutics for Multiple Myeloma

by Peter Bannas, Friedrich Koch-Nolte
Published 2018-11-01

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

by Peter Bannas, Julia Hambach, Friedrich Koch-Nolte
Published 2017-11-01

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity

by Stephan Menzel, Nicole Schwarz, Friedrich Haag, Friedrich Koch-Nolte
Published 2018-03-01

Targeting multiple myeloma with nanobody-based heavy chain antibodies, bispecific killer cell engagers, chimeric antigen receptors, and nanobody-displaying AAV vectors

by Julia Hambach, Julia Hambach, Anna Marei Mann, Peter Bannas, Friedrich Koch-Nolte
Published 2022-11-01

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells

by Björn Rissiek, Marco Lukowiak, Friederike Raczkowski, Tim Magnus, Hans-Willi Mittrücker, Friedrich Koch-Nolte
Published 2018-07-01

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy

by Larissa Jank, Carolina Pinto-Espinoza, Yinghui Duan, Friedrich Koch-Nolte, Tim Magnus, Björn Rissiek
Published 2019-01-01

T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD

by Friedrich Haag, Dunja Freese, Felix Scheublein, Wiebke Ohlrogge, Sahil Adriouch, Michel Seman, Friedrich Koch-Nolte
Published 2002-01-01

ADP-Ribosylation Regulates the Signaling Function of IFN-γ

by Stephan Menzel, Tomas Koudelka, Björn Rissiek, Friedrich Haag, Catherine Meyer-Schwesinger, Andreas Tholey, Friedrich Koch-Nolte
Published 2021-03-01

Astrocytes and Microglia Are Resistant to NAD+-Mediated Cell Death Along the ARTC2/P2X7 Axis

by Björn Rissiek, Joschi Stabernack, Maike Cordes, Yinghui Duan, Sarah Behr, Stephan Menzel, Tim Magnus, Friedrich Koch-Nolte
Published 2020-01-01

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD⁺ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

by Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Published 2020-12-01

CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.

by Chi-un Choe, Kerstin Lardong, Mathias Gelderblom, Peter Ludewig, Frank Leypoldt, Friedrich Koch-Nolte, Christian Gerloff, Tim Magnus
Published 2011-01-01

Correction: CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury after Focal Cerebral Ischemia.

by Chi-un Choe, Kerstin Lardong, Mathias Gelderblom, Peter Ludewig, Frank Leypoldt, Friedrich Koch-Nolte, Christian Gerloff, Tim Magnus
Published 2011-01-01

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.

by Birte Kretschmer, Katja Lüthje, Andreas H Guse, Svenja Ehrlich, Friedrich Koch-Nolte, Friedrich Haag, Bernhard Fleischer, Minka Breloer
Published 2007-08-01

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation.

by Michael Schneider, Valéa Schumacher, Timo Lischke, Karsten Lücke, Catherine Meyer-Schwesinger, Joachim Velden, Friedrich Koch-Nolte, Hans-Willi Mittrücker
Published 2015-01-01

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

by Abraham J. Cisneros-Mejorado, Alberto Pérez-Samartín, María Domercq, Rogelio O. Arellano, Miroslav Gottlieb, Friedrich Koch-Nolte, Carlos Matute
Published 2020-06-01

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

by Nicole Schwarz, Laurent Drouot, Annette Nicke, Ralf Fliegert, Olivier Boyer, Andreas H Guse, Friedrich Haag, Sahil Adriouch, Friedrich Koch-Nolte
Published 2012-01-01

Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation

by Kingsley Gideon Kumashie, Marcin Cebula, Claudia Hagedorn, Florian Kreppel, Marina C. Pils, Friedrich Koch-Nolte, Björn Rissiek, Dagmar Wirth, Dagmar Wirth
Published 2021-02-01

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation

by Thomas Eden, Stephan Menzel, Janusz Wesolowski, Philine Bergmann, Marion Nissen, Gudrun Dubberke, Fabienne Seyfried, Birte Albrecht, Friedrich Haag, Friedrich Koch-Nolte
Published 2018-01-01

Quantitative Magnetic Resonance Imaging of Enzyme Activity on the Cell Surface: In Vitro and In Vivo Monitoring of ADP-Ribosyltransferase 2 on T Cells

by Peter Bannas, Oliver Graumann, Philipp Balcerak, Kersten Peldschus, Michael Gerhard Kaul, Heinrich Hohenberg, Friedrich Haag, Gerhard Adam, Harald Ittrich, Friedrich Koch-Nolte
Published 2010-07-01

CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.

by Friederike Raczkowski, Anne Rissiek, Isabell Ricklefs, Kirsten Heiss, Valéa Schumacher, Kira Wundenberg, Friedrich Haag, Friedrich Koch-Nolte, Eva Tolosa, Hans-Willi Mittrücker
Published 2018-01-01