Friend and foe: β-cell Ca2+ signaling and the development of diabetes

by Paul V. Sabatini, Thilo Speckmann, Francis C. Lynn
Published 2019-03-01

TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm.

by Nicole A J Krentz, Cuilan Nian, Francis C Lynn
Published 2014-01-01

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

by Francis C Lynn, Lidia Sanchez, Ramon Gomis, Michael S German, Rosa Gasa
Published 2008-06-01

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

by Gina M Whitaker, Francis C Lynn, Christopher H S McIntosh, Eric A Accili
Published 2012-01-01

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).

by Miriam Ejarque, Joan Mir-Coll, Ramon Gomis, Michael S German, Francis C Lynn, Rosa Gasa
Published 2016-01-01

TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation

by Stephanie A. Campbell, Cassandra L. McDonald, Nicole A.J. Krentz, Francis C. Lynn, Brad G. Hoffman
Published 2019-08-01

A mouse model for monitoring islet cell genesis and developing therapies for diabetes

by Yoshinori Shimajiri, Yasuhiro Kosaka, David W. Scheel, Francis C. Lynn, Nina Kishimoto, Juehu Wang, Shuhong Zhao, Michael S. German
Published 2011-03-01

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

by Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
Published 2023-08-01

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

by Nicole A.J. Krentz, Michelle Y.Y. Lee, Eric E. Xu, Shannon L.J. Sproul, Alexandra Maslova, Shugo Sasaki, Francis C. Lynn
Published 2018-12-01

Islet amyloid polypeptide does not suppress pancreatic cancer

by Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Published 2023-02-01

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

by Jennifer E. Bruin, Suheda Erener, Javier Vela, Xiaoke Hu, James D. Johnson, Harley T. Kurata, Francis C. Lynn, James M. Piret, Ali Asadi, Alireza Rezania, Timothy J. Kieffer
Published 2014-01-01

Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells

by Paul V. Sabatini, Thilo Speckmann, Cuilan Nian, Maria M. Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A.M. James Shapiro, William T. Gibson, C. Bruce Verchere, Francis C. Lynn
Published 2018-01-01

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

by Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Published 2020-03-01

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

by Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Published 2020-01-01

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

by Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Published 2020-10-01

Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy

by Hugh J. McMillan, Aida Telegrafi, Amanda Singleton, Megan T. Cho, Daniel Lelli, Francis C. Lynn, Julie Griffin, Alexander Asamoah, Tuula Rinne, Corrie E. Erasmus, David A. Koolen, Charlotte A. Haaxma, Boris Keren, Diane Doummar, Cyril Mignot, Islay Thompson, Lea Velsher, Mohammadreza Dehghani, Mohammad Yahya Vahidi Mehrjardi, Reza Maroofian, Michel Tchan, Cas Simons, John Christodoulou, Elena Martín-Hernández, Maria J. Guillen Sacoto, Lindsay B. Henderson, Heather McLaughlin, Laurie L. Molday, Robert S. Molday, Grace Yoon
Published 2018-05-01

Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation

by Catherine M. Biggs, Anna Cordeiro-Santanach, Sergey V. Prykhozhij, Adam P. Deveau, Yi Lin, Kate L. Del Bel, Felix Orben, Robert J. Ragotte, Aabida Saferali, Sara Mostafavi, Louie Dinh, Darlene Dai, Katja G. Weinacht, Kerry Dobbs, Lisa Ott de Bruin, Mehul Sharma, Kevin Tsai, John J. Priatel, Richard A. Schreiber, Jacob Rozmus, Martin C.K. Hosking, Kevin E. Shopsowitz, Margaret L. McKinnon, Suzanne Vercauteren, Michael Seear, Luigi D. Notarangelo, Francis C. Lynn, Jason N. Berman, Stuart E. Turvey
Published 2022-12-01