Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase.

by Olivier Kosmider, Dorothée Buet, Isabelle Gallais, Nicole Denis, Françoise Moreau-Gachelin
Published 2009-05-01

Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells.

by Dorothée Selimoglu-Buet, Isabelle Gallais, Nicole Denis, Christel Guillouf, Françoise Moreau-Gachelin
Published 2012-01-01