Barrier Function Assay

by Tia DiTommaso, Floris Foijer
Published 2014-05-01

Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer

by Lin Zhou, Laura J. Jilderda, Floris Foijer
Published 2020-09-01

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability

by Christy Hong, Andrea E. Tijhuis, Floris Foijer
Published 2019-10-01

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer

by Laura J. Jilderda, Lin Zhou, Floris Foijer
Published 2021-02-01

Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies

by Siqi Zheng, Erika Guerrero-Haughton, Floris Foijer
Published 2023-11-01

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

by Mar Soto, Jonne A. Raaijmakers, Bjorn Bakker, Diana C.J. Spierings, Peter M. Lansdorp, Floris Foijer, René H. Medema
Published 2017-06-01

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer c...

by Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. vanVugt
Published 2019-11-01

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

by Klaske M. Schukken, Yinan Zhu, Petra L. Bakker, Mirjam H. Koster, Liesbeth Harkema, Sameh A. Youssef, Alain de Bruin, Floris Foijer
Published 2021-01-01

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

by Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
Published 2018-07-01

Non-random Mis-segregation of Human Chromosomes

by Joseph Thomas Worrall, Naoka Tamura, Alice Mazzagatti, Nadeem Shaikh, Tineke van Lingen, Bjorn Bakker, Diana Carolina Johanna Spierings, Elina Vladimirou, Floris Foijer, Sarah Elizabeth McClelland
Published 2018-06-01

RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABAA receptors involved in volume regulation.

by Camiel L C Wielders, Pim van Nierop, Tinke L Vormer, Floris Foijer, Joanne Verheij, Johannes C Lodder, Jesper B Andersen, Huibert D Mansvelder, Hein Te Riele
Published 2018-01-01

Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

by Bente Benedict, Tanja van Harn, Marleen Dekker, Simone Hermsen, Asli Kucukosmanoglu, Wietske Pieters, Elly Delzenne-Goette, Josephine C Dorsman, Eva Petermann, Floris Foijer, Hein te Riele
Published 2018-10-01

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

by Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Published 2017-07-01

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.

by Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Published 2022-01-01

MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma

by Saskia Sydow, Paul Piccinelli, Shamik Mitra, Panagiotis Tsagkozis, Asle Hesla, Camila B. R. De Mattos, Jan Köster, Linda Magnusson, Jenny Nilsson, Adam Ameur, René Wardenaar, Floris Foijer, Diana Spierings, Fredrik Mertens
Published 2024-05-01

Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses

by Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C. Johnson, Bjorn Bakker, Diana C. J. Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A. Boemo, Floris Foijer, Sarah E. McClelland
Published 2022-10-01

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

by Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer
Published 2021-09-01

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

by Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor
Published 2021-10-01

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

by Amanda Faria Assoni, Thiago Giove Mitsugi, René Wardenaar, Raiane Oliveira Ferreira, Elisa Helena Farias Jandrey, Gabriela Machado Novaes, Isabela Fonseca de Oliveira Granha, Petra Bakker, Carolini Kaid, Mayana Zatz, Floris Foijer, Oswaldo Keith Okamoto
Published 2023-11-01

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

by Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Published 2017-03-01