The Mechanism of RNA Interference and the Transposon Silencing in Caenorhabditis elegans

by Marcel Tijsterman, Rena Ketting, Sylvia Fischer, Femke Simmer, Titia Sijen, Kristy Okihara, Bas Tops, Nadine Vastenhouw, Ronald Plasterk
Published 2002-01-01

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

by Corina N. A. M. van den Heuvel, Arvid I. Das, Tessa de Bitter, Femke Simmer, Thomas Wurdinger, Miguel Angel Molina-Vila, William P. J. Leenders
Published 2018-05-01

Semi-Supervised Learning to Automate Tumor Bud Detection in Cytokeratin-Stained Whole-Slide Images of Colorectal Cancer

by John-Melle Bokhorst, Iris D. Nagtegaal, Inti Zlobec, Heather Dawson, Kieran Sheahan, Femke Simmer, Richard Kirsch, Michael Vieth, Alessandro Lugli, Jeroen van der Laak, Francesco Ciompi
Published 2023-03-01

Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.

by Femke Simmer, Celine Moorman, Alexander M van der Linden, Ewart Kuijk, Peter V E van den Berghe, Ravi S Kamath, Andrew G Fraser, Julie Ahringer, Ronald H A Plasterk
Published 2003-10-01

Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

by Alessia Buscaino, Sharon A White, Douglas R Houston, Erwan Lejeune, Femke Simmer, Flavia de Lima Alves, Piyush T Diyora, Takeshi Urano, Elizabeth H Bayne, Juri Rappsilber, Robin C Allshire
Published 2012-02-01

Intra-Tumoral Genomic Heterogeneity in Rectal Cancer: Mutational Status Is Dependent on Preoperative Biopsy Depth and Location

by Floris A. Vuijk, Carlijn van de Water, Shannon Lent-van Vliet, Maxime J. M. van der Valk, Femke Simmer, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer, Iris D. Nagtegaal, Denise E. Hilling
Published 2021-05-01

Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients

by Tessa J. J. de Bitter, Philip R. de Reuver, Elise A. J. de Savornin Lohman, Leonie I. Kroeze, Marianne E. Vink-Börger, Shannon van Vliet, Femke Simmer, Daniel von Rhein, Erik A. M. Jansen, Joanne Verheij, Carla M. L. van Herpen, Iris D. Nagtegaal, Marjolijn J. L. Ligtenberg, Rachel S. van der Post
Published 2022-11-01

Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a

by Rachel Deplus, Loïc Blanchon, Arumugam Rajavelu, Abdelhalim Boukaba, Matthieu Defrance, Judith Luciani, Françoise Rothé, Sarah Dedeurwaerder, Hélène Denis, Arie B. Brinkman, Femke Simmer, Fabian Müller, Benjamin Bertin, Maria Berdasco, Pascale Putmans, Emilie Calonne, David W. Litchfield, Yvan de Launoit, Tomasz P. Jurkowski, Hendrik G. Stunnenberg, Christoph Bock, Christos Sotiriou, Mario F. Fraga, Manel Esteller, Albert Jeltsch, François Fuks
Published 2014-08-01

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

by Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Published 2019-04-01

Quantitative Comparison of Genome-wide DNA Methylation Mapping Technologies

by Bock, Christoph, Tomazou, Eleni M., Brinkman, Arie B., Müller, Fabian, Simmer, Femke, Gu, Hongcang, Jäger, Natalie, Gnirke, Andreas, Stunnenberg, Hendrik G., Meissner, Alexander
Published 2015

Sequential ChIP-Bisulfite Sequencing Enables Direct Genome-Scale Investigation of Chromatin and DNA Methylation Cross-Talk

by Brinkman, Arie B., Gu, Hangcang, Bartels, Stefanie J. J., Zhang, Yingying, Matarese, Filomena, Simmer, Femke, Marks, Hendrik, Bock, Christoph, Gnirke, Andreas, Meissner, Alexander, Stunnenberg, Hendrik G.
Published 2015