Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother–child pairs

by Jaakko T. Leinonen, FinnGen, Matti Pirinen, Taru Tukiainen
Published 2024-02-01

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

by Max Tamlander, Nina Mars, Matti Pirinen, FinnGen, Elisabeth Widén, Samuli Ripatti
Published 2022-02-01

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

by Eeva Sliz, Jaakko S. Tyrmi, Nilufer Rahmioglu, Krina T. Zondervan, Christian M. Becker, FinnGen, Outi Uimari, Johannes Kettunen
Published 2023-02-01

Causal relationship between gut microbiota and immune thrombocytopenia: a Mendelian randomization study of two samples

by Dongmei Guo, Dongmei Guo, Qian Chen, Qian Chen, Guojun Wang, Guojun Wang, ChunPu Li, ChunPu Li, FinnGen consortium
Published 2023-11-01

Use of electronic health record data mining for heart failure subtyping

by Matti A. Vuori, Tuomo Kiiskinen, Niina Pitkänen, Samu Kurki, Hannele Laivuori, Tarja Laitinen, Sampo Mäntylahti, Aarno Palotie, FinnGen, Teemu J. Niiranen
Published 2023-09-01

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

by Linda Ottensmann, Rubina Tabassum, Sanni E. Ruotsalainen, Mathias J. Gerl, Christian Klose, Elisabeth Widén, FinnGen, Kai Simons, Samuli Ripatti, Matti Pirinen
Published 2023-10-01

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease.

by Pyry Helkkula, Tuomo Kiiskinen, Aki S Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti, FinnGen
Published 2021-04-01

Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects

by Martin Broberg, Minna Ampuja, Samuel Jones, Tiina Ojala, Otto Rahkonen, Riikka Kivelä, James Priest, FinnGen, Aarno Palotie, Hanna M. Ollila, Emmi Helle
Published 2024-03-01

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

by Pyry Helkkula, Shabbeer Hassan, Elmo Saarentaus, Emilia Vartiainen, Sanni Ruotsalainen, Jaakko T. Leinonen, FinnGen, Aarno Palotie, Juha Karjalainen, Mitja Kurki, Samuli Ripatti, Taru Tukiainen
Published 2023-01-01

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks

by Rounak Dey, Wei Zhou, Tuomo Kiiskinen, Aki Havulinna, Amanda Elliott, Juha Karjalainen, Mitja Kurki, Ashley Qin, FinnGen, Seunggeun Lee, Aarno Palotie, Benjamin Neale, Mark Daly, Xihong Lin
Published 2022-09-01

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

by Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, FinnGen, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Published 2020-12-01

Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.

by Anu Pasanen, Minna K Karjalainen, FinnGen, Ge Zhang, Heli Tiensuu, Antti M Haapalainen, Marja Ojaniemi, Bjarke Feenstra, Bo Jacobsson, Aarno Palotie, Hannele Laivuori, Louis J Muglia, Mika Rämet, Mikko Hallman
Published 2023-10-01

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma.

by Yosuke Tanigawa, Michael Wainberg, Juha Karjalainen, Tuomo Kiiskinen, Guhan Venkataraman, Susanna Lemmelä, Joni A Turunen, Robert R Graham, Aki S Havulinna, Markus Perola, Aarno Palotie, FinnGen, Mark J Daly, Manuel A Rivas
Published 2020-05-01

Genetic analyses implicate complex links between adult testosterone levels and health and disease

by Jaakko T. Leinonen, Nina Mars, Leevi E. Lehtonen, Ari Ahola-Olli, Sanni Ruotsalainen, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, FinnGen Consortium, Terhi Piltonen, Mark Daly, Tiinamaija Tuomi, Samuli Ripatti, Matti Pirinen, Taru Tukiainen
Published 2023-01-01

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

by João Fadista, Line Skotte, Juha Karjalainen, Erik Abner, Erik Sørensen, Henrik Ullum, Thomas Werge, iPSYCH Group, Tõnu Esko, Lili Milani, Aarno Palotie, Mark Daly, FinnGen Consortium, Mads Melbye, Bjarke Feenstra, Frank Geller
Published 2022-06-01

NTHL1 is a recessive cancer susceptibility gene

by Anna K. Nurmi, Liisa M. Pelttari, Johanna I. Kiiski, Sofia Khan, Mika Nurmikolu, Maija Suvanto, Niina Aho, Tiina Tasmuth, Eija Kalso, Johanna Schleutker, Anne Kallioniemi, Päivi Heikkilä, FinnGen, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna
Published 2023-11-01

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

by Elmo C. Saarentaus, Juha Karjalainen, Joel T. Rämö, Tuomo Kiiskinen, Aki S. Havulinna, Juha Mehtonen, Heidi Hautakangas, Sanni Ruotsalainen, Max Tamlander, Nina Mars, FINNGEN, Sanna Toppila-Salmi, Matti Pirinen, Mitja Kurki, Samuli Ripatti, Mark Daly, Tuula Palotie, Antti Mäkitie, Aarno Palotie
Published 2023-01-01

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study

by Samu N. Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mäyränpää, Henri Puttonen, FinnGen, Juha Martola, Minna Pöyhönen, Mia Kero, Jarno Tuimala, Olli Carpén, Anu Kantele, Olli Vapalahti, Marjaana Tiainen, Pentti J. Tienari, Kai Kaila, Johanna Hästbacka, Liisa Myllykangas
Published 2021-12-01

Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

by Pavel Loginovic, Feiyi Wang, Jiang Li, Lauric Ferrat, Uyenlinh L. Mirshahi, H. Shanker Rao, Axel Petzold, Jessica Tyrrell, Harry D. Green, Michael N. Weedon, Andrea Ganna, Tiinamaija Tuomi, David J. Carey, UKBB Eye & Vision Consortium, FinnGen, Geisinger-Regeneron DiscovEHR Collaboration, Richard A. Oram, Tasanee Braithwaite
Published 2024-02-01

Deep learning of left atrial structure and function provides link to atrial fibrillation risk

by James P. Pirruccello, Paolo Di Achille, Seung Hoan Choi, Joel T. Rämö, Shaan Khurshid, Mahan Nekoui, Sean J. Jurgens, Victor Nauffal, Shinwan Kany, FinnGen, Kenney Ng, Samuel F. Friedman, Puneet Batra, Kathryn L. Lunetta, Aarno Palotie, Anthony A. Philippakis, Jennifer E. Ho, Steven A. Lubitz, Patrick T. Ellinor
Published 2024-05-01