Economic Evaluation of Digital Therapeutic Care Apps for Unsupervised Treatment of Low Back Pain: Monte Carlo Simulation

by Daniel Lewkowicz, Erwin Bottinger, Martin Siegel
Published 2023-06-01

StudyMe: a new mobile app for user-centric N-of-1 trials

by Alexander M. Zenner, Erwin Böttinger, Stefan Konigorski
Published 2022-12-01

Digital Therapeutic Care Apps With Decision-Support Interventions for People With Low Back Pain in Germany: Cost-Effectiveness Analysis

by Daniel Lewkowicz, Attila M Wohlbrandt, Erwin Bottinger
Published 2022-02-01

Can genetic pleiotropy replicate common clinical constellations of cardiovascular disease and risk?

by Omri Gottesman, Esther Drill, Vaneet Lotay, Erwin Bottinger, Inga Peter
Published 2012-01-01

Digital Therapeutic Care and Decision Support Interventions for People With Low Back Pain: Systematic Review

by Daniel Lewkowicz, Tamara Slosarek, Sarah Wernicke, Antonia Winne, Attila M Wohlbrandt, Erwin Bottinger
Published 2021-11-01

Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.

by Shaolin Shi, Liping Yu, Taoran Zhang, Haiying Qi, Sandhya Xavier, Wenjun Ju, Erwin Bottinger
Published 2013-01-01

Inducing and Recording Acute Stress Responses on a Large Scale With the Digital Stress Test (DST): Development and Evaluation Study

by Matthias Norden, Amin Gerard Hofmann, Martin Meier, Felix Balzer, Oliver T Wolf, Erwin Böttinger, Hanna Drimalla
Published 2022-07-01

BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.

by Sandhya Xavier, Victoria Gilbert, Maria Pia Rastaldi, Stefanie Krick, Dmitrij Kollins, Anand Reddy, Erwin Bottinger, Clemens D Cohen, Detlef Schlondorff
Published 2010-09-01

BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.

by Nicolas Guillot, Dmitrij Kollins, Victoria Gilbert, Sandhya Xavier, Jun Chen, Madeleine Gentle, Anand Reddy, Erwin Bottinger, Rulang Jiang, Maria Pia Rastaldi, Alessandro Corbelli, Detlef Schlondorff
Published 2012-01-01

Development of the ehive Digital Health App: Protocol for a Centralized Research Platform

by Robert P Hirten, Matteo Danieletto, Kyle Landell, Micol Zweig, Eddye Golden, Georgy Orlov, Jovita Rodrigues, Eugenia Alleva, Ipek Ensari, Erwin Bottinger, Girish N Nadkarni, Thomas J Fuchs, Zahi A Fayad
Published 2023-11-01

Human and murine kidneys show gender- and species-specific gene expression differences in response to injury.

by Han Si, Ramandeep S Banga, Pinelopi Kapitsinou, Manjunath Ramaiah, Janis Lawrence, Ganesh Kambhampati, Antje Gruenwald, Erwin Bottinger, Daniel Glicklich, Vivian Tellis, Stuart Greenstein, David B Thomas, James Pullman, Melissa Fazzari, Katalin Susztak
Published 2009-01-01

StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials

by Stefan Konigorski, Sarah Wernicke, Tamara Slosarek, Alexander M Zenner, Nils Strelow, Darius F Ruether, Florian Henschel, Manisha Manaswini, Fabian Pottbäcker, Jonathan A Edelman, Babajide Owoyele, Matteo Danieletto, Eddye Golden, Micol Zweig, Girish N Nadkarni, Erwin Böttinger
Published 2022-07-01

A conceptual model for translating omic data into clinical action

by Timothy M Herr, Suzette J Bielinski, Erwin Bottinger, Ariel Brautbar, Murray Brilliant, Christopher G Chute, Joshua Denny, Robert R Freimuth, Andrea Hartzler, Joseph Kannry, Isaac S Kohane, Iftikhar J Kullo, Simon Lin, Jyotishman Pathak, Peggy Peissig, Jill Pulley, James Ralston, Luke Rasmussen, Dan Roden, Gerard Tromp, Marc S Williams, Justin Starren
Published 2015-01-01

Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm.

by Yoonjung Yoonie Joo, Jennifer A Pacheco, William K Thompson, Laura J Rasmussen-Torvik, Luke V Rasmussen, Frederick T J Lin, Mariza de Andrade, Kenneth M Borthwick, Erwin Bottinger, Andrew Cagan, David S Carrell, Joshua C Denny, Stephen B Ellis, Omri Gottesman, James G Linneman, Jyotishman Pathak, Peggy L Peissig, Ning Shang, Gerard Tromp, Annapoorani Veerappan, Maureen E Smith, Rex L Chisholm, Andrew J Gawron, M Geoffrey Hayes, Abel N Kho
Published 2023-01-01

Practical considerations in genomic decision support: The eMERGE experience

by Timothy M Herr, Suzette J Bielinski, Erwin Bottinger, Ariel Brautbar, Murray Brilliant, Christopher G Chute, Beth L Cobb, Joshua C Denny, Hakon Hakonarson, Andrea L Hartzler, George Hripcsak, Joseph Kannry, Isaac S Kohane, Iftikhar J Kullo, Simon Lin, Shannon Manzi, Keith Marsolo, Casey Lynnette Overby, Jyotishman Pathak, Peggy Peissig, Jill Pulley, James Ralston, Luke Rasmussen, Dan M Roden, Gerard Tromp, Timothy Uphoff, Chunhua Weng, Wendy Wolf, Marc S Williams, Justin Starren
Published 2015-01-01

COVID-19 in German Competitive Sports: Protocol for a Prospective Multicenter Cohort Study (CoSmo-S)

by Andreas Michael Niess, Manuel Widmann, Roman Gaidai, Christian Gölz, Isabel Schubert, Katty Castillo, Jan Philipp Sachs, Daniel Bizjak, Shirin Vollrath, Fritz Wimbauer, Azin Vogel, Karsten Keller, Karsten Keller, Christof Burgstahler, Anne Quermann, Arno Kerling, Gerald Schneider, Jonas Zacher, Katharina Diebold, Maximilian Grummt, Claudia Beckendorf, Johannes Buitenhuis, Florian Egger, Andreas Venhorst, Oliver Morath, Friedrich Barsch, Klaus-Peter Mellwig, Julian Oesterschlink, Jan Wüstenfeld, Jan Wüstenfeld, Hans-Georg Predel, Peter Deibert, Birgit Friedmann-Bette, Frank Mayer, Anja Hirschmüller, Martin Halle, Jürgen Michael Steinacker, Bernd Wolfarth, Bernd Wolfarth, Tim Meyer, Erwin Böttinger, Marion Flechtner-Mors, Wilhelm Bloch, Bernhard Haller, Kai Roecker, Claus Reinsberger
Published 2022-02-01

Genome-wide study of resistant hypertension identified from electronic health records.

by Logan Dumitrescu, Marylyn D Ritchie, Joshua C Denny, Nihal M El Rouby, Caitrin W McDonough, Yuki Bradford, Andrea H Ramirez, Suzette J Bielinski, Melissa A Basford, High Seng Chai, Peggy Peissig, David Carrell, Jyotishman Pathak, Luke V Rasmussen, Xiaoming Wang, Jennifer A Pacheco, Abel N Kho, M Geoffrey Hayes, Martha Matsumoto, Maureen E Smith, Rongling Li, Rhonda M Cooper-DeHoff, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Gail P Jarvik, Eric B Larson, David Carey, Catherine A McCarty, Marc S Williams, Dan M Roden, Erwin Bottinger, Julie A Johnson, Mariza de Andrade, Dana C Crawford
Published 2017-01-01

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

by Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler
Published 2021-06-01

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

by Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S. Ngwa, Tarunveer S. Ahluwalia, Audrey Y. Chu, Nancy L. Heard-Costa, Elise Lim, Jeremiah Perez, John D. Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan, Frida Renström, Joseph Wu, Qibin Qi, Shafqat Ahmad, Tamuno Alfred, Najaf Amin, Lawrence F. Bielak, Amelie Bonnefond, Jennifer Bragg, Gemma Cadby, Martina Chittani, Scott Coggeshall, Tanguy Corre, Nese Direk, Joel Eriksson, Krista Fischer, Mathias Gorski, Marie Neergaard Harder, Momoko Horikoshi, Tao Huang, Jennifer E. Huffman, Anne U. Jackson, Johanne Marie Justesen, Stavroula Kanoni, Leena Kinnunen, Marcus E. Kleber, Pirjo Komulainen, Meena Kumari, Unhee Lim, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Rita P. S. Middelberg, Martina Müller-Nurasyid, Pau Navarro, Louis Pérusse, Natalia Pervjakova, Cinzia Sarti, Albert Vernon Smith, Jennifer A. Smith, Alena Stančáková, Rona J. Strawbridge, Heather M. Stringham, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Peter J. van der Most, Jana V. Van Vliet-Ostaptchouk, Sailaja L. Vedantam, Niek Verweij, Jacqueline M. Vink, Veronique Vitart, Ying Wu, Loic Yengo, Weihua Zhang, Jing Hua Zhao, Martina E. Zimmermann, Niha Zubair, Gonçalo R. Abecasis, Linda S. Adair, Saima Afaq, Uzma Afzal, Stephan J. L. Bakker, Traci M. Bartz, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Daniele Braga, Brendan M. Buckley, Steve Buyske, Harry Campbell, John C. Chambers, Francis S. Collins, Joanne E. Curran, Gert J. de Borst, Anton J. M. de Craen, Eco J. C. de Geus, George Dedoussis, Graciela E. Delgado, Hester M. den Ruijter, Gudny Eiriksdottir, Anna L. Eriksson, Tõnu Esko, Jessica D. Faul, Ian Ford, Terrence Forrester, Karl Gertow, Bruna Gigante, Nicola Glorioso, Jian Gong, Harald Grallert, Tanja B. Grammer, Niels Grarup, Saskia Haitjema, Göran Hallmans, Anders Hamsten, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas D. Hastie, Andrew C. Heath, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Mette Hollensted, Oddgeir L. Holmen, Georg Homuth, Jouke Jan Hottenga, Jie Huang, Joseph Hung, Nina Hutri-Kähönen, Erik Ingelsson, Alan L. James, John-Olov Jansson, Marjo-Riitta Jarvelin, Min A. Jhun, Marit E. Jørgensen, Markus Juonala, Mika Kähönen, Magnus Karlsson, Heikki A. Koistinen, Ivana Kolcic, Genovefa Kolovou, Charles Kooperberg, Bernhard K. Krämer, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Karin Leander, Nanette R. Lee, Lars Lind, Cecilia M. Lindgren, Allan Linneberg, Stephane Lobbens, Marie Loh, Mattias Lorentzon, Robert Luben, Gitta Lubke, Anja Ludolph-Donislawski, Sara Lupoli, Pamela A. F. Madden, Reija Männikkö, Pedro Marques-Vidal, Nicholas G. Martin, Colin A. McKenzie, Barbara McKnight, Dan Mellström, Cristina Menni, Grant W. Montgomery, AW (Bill) Musk, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Patricia A. Peyser, Charlotta Pisinger, David J. Porteous, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Laura J. Rasmussen-Torvik, Rajesh Rawal, Treva Rice, Paul M. Ridker, Lynda M. Rose, Stephanie A. Bien, Igor Rudan, Serena Sanna, Mark A. Sarzynski, Naveed Sattar, Kai Savonen, David Schlessinger, Salome Scholtens, Claudia Schurmann, Robert A. Scott, Bengt Sennblad, Marten A. Siemelink, Günther Silbernagel, P Eline Slagboom, Harold Snieder, Jan A. Staessen, David J. Stott, Morris A. Swertz, Amy J. Swift, Kent D. Taylor, Bamidele O. Tayo, Barbara Thorand, Dorothee Thuillier, Jaakko Tuomilehto, Andre G. Uitterlinden, Liesbeth Vandenput, Marie-Claude Vohl, Henry Völzke, Judith M. Vonk, Gérard Waeber, Melanie Waldenberger, R. G. J. Westendorp, Sarah Wild, Gonneke Willemsen, Bruce H. R. Wolffenbuttel, Andrew Wong, Alan F. Wright, Wei Zhao, M Carola Zillikens, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Carsten A. Böger, Dorret I. Boomsma, Claude Bouchard, Marcel Bruinenberg, Daniel I. Chasman, Yii-DerIda Chen, Peter S. Chines, Richard S. Cooper, Francesco Cucca, Daniele Cusi, Ulf de Faire, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Penny Gordon-Larsen, Hans- Jörgen Grabe, Vilmundur Gudnason, Christopher A. Haiman, Caroline Hayward, Kristian Hveem, Andrew D. Johnson, J Wouter Jukema, Sharon L. R. Kardia, Mika Kivimaki, Jaspal S. Kooner, Diana Kuh, Markku Laakso, Terho Lehtimäki, Loic Le Marchand, Winfried März, Mark I. McCarthy, Andres Metspalu, Andrew P. Morris, Claes Ohlsson, Lyle J. Palmer, Gerard Pasterkamp, Oluf Pedersen, Annette Peters, Ulrike Peters, Ozren Polasek, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Blair H. Smith, Thorkild I. A. Sørensen, Konstantin Strauch, Henning Tiemeier, Elena Tremoli, Pim van der Harst, Henrik Vestergaard, Peter Vollenweider, Nicholas J. Wareham, David R. Weir, John B. Whitfield, James F. Wilson, Jessica Tyrrell, Timothy M. Frayling, Inês Barroso, Michael Boehnke, Panagiotis Deloukas, Caroline S. Fox, Joel N. Hirschhorn, David J. Hunter, Tim D. Spector, David P. Strachan, Cornelia M. van Duijn, Iris M. Heid, Karen L. Mohlke, Jonathan Marchini, Ruth J. F. Loos, Tuomas O. Kilpeläinen, Ching-Ti Liu, Ingrid B. Borecki, Kari E. North, L Adrienne Cupples
Published 2017-04-01