Base editing technology

by Yidi SUN, Erwei ZUO, Hui YANG
Published 2020-06-01

EpiCas-DL: Predicting sgRNA activity for CRISPR-mediated epigenome editing by deep learning

by Qianqian Yang, Leilei Wu, Juan Meng, Lei Ma, Erwei Zuo, Yidi Sun
Published 2023-01-01

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Inherited Diseases

by Sameh A. Abdelnour, Sameh A. Abdelnour, Long Xie, Abdallah A. Hassanin, Erwei Zuo, Yangqing Lu
Published 2021-12-01

An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs

by Long Xie, Zhenwen Huang, Meiyu Lan, Yaqi Cao, Lingling Sun, Lang Zhang, Erwei Zuo, Yangqing Lu
Published 2024-01-01

FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells

by Di Li, Yaqi Cao, Long Xie, Chenfei He, Danrong Jiao, Mengxue Ma, Zhenrui Zuo, Erwei Zuo, Xiaogan Yang
Published 2024-04-01

Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

by Yinghui Wei, Zhifang Li, Kui Xu, Hu Feng, Long Xie, Di Li, Zhenrui Zuo, Meiling Zhang, Chunlong Xu, Hui Yang, Erwei Zuo
Published 2022-03-01

Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice

by Zixiang Yan, Yuqin Yao, Luyao Li, Lingqiong Cai, Haiwei Zhang, Shenghai Zhang, Qingquan Xiao, Xing Wang, Erwei Zuo, Chunlong Xu, Jihong Wu, Hui Yang
Published 2023-09-01

Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints

by Qinchang Chen, Guohui Chuai, Haihang Zhang, Jin Tang, Liwen Duan, Huan Guan, Wenhui Li, Wannian Li, Jiaying Wen, Erwei Zuo, Qing Zhang, Qi Liu
Published 2023-11-01

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

by Yinghui Wei, Chunlong Xu, Hu Feng, Kui Xu, Zhifang Li, Jing Hu, Ling Zhou, Yu Wei, Zhenrui Zuo, Erwei Zuo, Wen Li, Hui Yang, Meiling Zhang
Published 2022-02-01

Develop an efficient and specific AAV-based labeling system for Muller glia in mice

by Yanxia Gao, Kailun Fang, Zixiang Yan, Haiwei Zhang, Guannan Geng, Weiwei Wu, Ding Xu, Heng Zhang, Na Zhong, Qifang Wang, Minqing Cai, Erwei Zuo, Hui Yang
Published 2022-12-01

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

by Nana Yan, Hu Feng, Yongsen Sun, Ying Xin, Haihang Zhang, Hongjiang Lu, Jitan Zheng, Chenfei He, Zhenrui Zuo, Tanglong Yuan, Nana Li, Long Xie, Wu Wei, Yidi Sun, Erwei Zuo
Published 2023-03-01

Undetectable off-target effects induced by FokI catalytic domain in mouse embryos

by Long Xie, Hu Feng, Zhifang Li, Di Li, Xiali Yang, Tanglong Yuan, Nana Yan, Chenfei He, Jitan Zheng, Zhenrui Zuo, Yaxuan Zheng, Yaqi Cao, Yangqing Lu, Xing Yao Xiong, Erwei Zuo
Published 2024-02-01

Mini-dCas13X–mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy

by Guoling Li, Ming Jin, Zhifang Li, Qingquan Xiao, Jiajia Lin, Dong Yang, Yuanhua Liu, Xing Wang, Long Xie, Wenqin Ying, Haoqiang Wang, Erwei Zuo, Linyu Shi, Ning Wang, Wanjin Chen, Chunlong Xu, Hui Yang
Published 2023-02-01

Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods

by Tanglong Yuan, Nana Yan, Tianyi Fei, Jitan Zheng, Juan Meng, Nana Li, Jing Liu, Haihang Zhang, Long Xie, Wenqin Ying, Di Li, Lei Shi, Yongsen Sun, Yongyao Li, Yixue Li, Yidi Sun, Erwei Zuo
Published 2021-08-01

CRISPR/Cas9-mediated targeted chromosome elimination

by Erwei Zuo, Xiaona Huo, Xuan Yao, Xinde Hu, Yidi Sun, Jianhang Yin, Bingbing He, Xing Wang, Linyu Shi, Jie Ping, Yu Wei, Wenqin Ying, Wei Wei, Wenjia Liu, Cheng Tang, Yixue Li, Jiazhi Hu, Hui Yang
Published 2017-11-01

Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

by Tanglong Yuan, Leilei Wu, Shiyan Li, Jitan Zheng, Nana Li, Xiao Xiao, Haihang Zhang, Tianyi Fei, Long Xie, Zhenrui Zuo, Di Li, Pinzheng Huang, Hu Feng, Yaqi Cao, Nana Yan, Xinming Wei, Lei Shi, Yongsen Sun, Wu Wei, Yidi Sun, Erwei Zuo
Published 2024-02-01

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

by Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, Xin-Xin Guo, Yun-Lu Li, Chong Wang, Zhi-Yuan Zhao, Xue-Jing Huang, Kai-Jun Lin, Zi-Ling Ye, Bi-Wei Lin, Shunyan Hong, Jitan Zheng, Yao-Bin Liu, Xiang-Ping Yao, Dehao Yang, Ying-Qian Lu, Hai-Zhu Chen, Erwei Zuo, Guang Yang, Hong-Tao Wang, Chen-Wei Huang, Xiao-Hong Lin, Zhidong Cen, Lu-Lu Lai, Yan-Ke Zhang, Xi Li, Tianmin Lai, Jingjing Lin, Dan-Dan Zuo, Min-Ting Lin, Chia-Wei Liou, Qing-Xia Kong, Chuan-Zhu Yan, Zhi-Qi Xiong, Ning Wang, Wei Luo, Cui-Ping Zhao, Xuewen Cheng, Wan-Jin Chen
Published 2022-11-01